Citation: Fan-dong Meng, Yun-xia Ni, Si-fan Ji, Xiao-hui Fu, Yu-han Wei, Jing Sun, Zhi-bo Li. Dual Thermal-and pH-responsive Polypeptide-based Hydrogels[J]. Chinese Journal of Polymer Science, ;2017, 35(10): 1243-1252. doi: 10.1007/s10118-017-1959-9 shu

Dual Thermal-and pH-responsive Polypeptide-based Hydrogels

School of Polymer Science and Engineering, Qingdao University of Science and Technology, Qingdao 266042, China

Corresponding author: Jing Sun, jingsun@qust.edu.cn Zhi-bo Li, zbli@qust.edu.cn
Received Date: 7 April 2017
Revised Date: 26 April 2017
Accepted Date: 26 April 2017

Fund Project: the National Natural Science Foundation of China 21434008Natural Science Foundation of Shandong Province ZR2015EM015the National Natural Science Foundation of China 51225306

Smart hydrogels have received increasing attention for their great potential for the applications in many fields. Herein, we report a facile approach to prepare a class of dual-responsive hydrogels assembled from synthetic statistical/block thermal-responsive copoly(L-glutamate)s copolymerized with poly(ethylene glycol), which were prepared by ring-opening polymerization (ROP) and post-modification strategy. The incorporation of oligo(ethylene glycol) (OEG) and glutamic acid residues offers the gels with thermal- and pH-responsive properties simultaneously. We have systematically studied the influence of both temperature and pH on the gelation behaviors of these copolymers. It is found that the increase of glutamic acid content and solution pH values can significantly suppress the gelation ability of the samples. Circular dichroism (CD) results show that the α-helix conformation appears to be the dominant secondary conformation. More interestingly, the gelation property of the block copolymer with statistical thermal-responsive copoly(L-glutamate)s shows greater dependence on pH as compared to that with block segments due to the distinct morphology of the self-assemblies. The obtained hydrogels exhibit pH-dependent and thermal-responsive gelation behaviors, which enable them as an ideal smart hydrogel system for biomedical applications.
- pH-responsive,
- Thermal-responsive,
- Hydrogel,
- Polypeptide
1. [1]
  Kopecek, J., Biomaterials, 2007, 28(34):5185 doi: 10.1016/j.biomaterials.2007.07.044
2. [2]
  Li, Y., Rodrigues, J. and Tomas, H., Chem. Soc. Rev., 2011, 41(6):2193
3. [3]
  Nowak, A.P., Breedveld, V., Pakstis, L., Ozbas, B., Pine, D.J., Pochan, D. and Deming, T.J., Nature, 2002, 417(6887):424 doi: 10.1038/417424a
4. [4]
  Wright, E.R., Mcmillan, R.A., Cooper, A., Apkarian, R.P. and Conticello, V.P., Adv. Funct. Mater., 2002, 12(2):149 doi: 10.1002/(ISSN)1616-3028
5. [5]
  Yu, L. and Ding, J., Chem. Soc. Rev., 2008, 37(8):1473 doi: 10.1039/b713009k
6. [6]
  Chan, T.R., Stahl, P.J. and Yu, S.M., Adv. Funct. Mater., 2011, 21(22):4252 doi: 10.1002/adfm.201101163
7. [7]
  Nagarkar, P.R., Hule, A.R., Pochan, J.D. and Schneider, P.J., J. Am. Chem. Soc., 2008, 130(13):4466 doi: 10.1021/ja710295t
8. [8]
  Deming, T.J., Prog. Polym. Sci., 2007, 32(8-9):858 doi: 10.1016/j.progpolymsci.2007.05.010
9. [9]
  Shen, Y., Fu, X., Fu, W. and Li, Z., Chem. Soc. Rev., 2015, 44:612 doi: 10.1039/C4CS00271G
10. [10]
  Altunbas, A. and Pochan, D.J., Top. Curr. Chem., 2011, 310(5):135
11. [11]
  Yan, C. and Pochan, D.J., Chem. Soc. Rev., 2010, 39(9):3528 doi: 10.1039/b919449p
12. [12]
  Charati, M.B., Lee, I., Hribar, K.C. and Burdick, J.A., Small, 2010, 6(15):1608 doi: 10.1002/smll.v6:15
13. [13]
  Wu, L.Y., Yu, L., Fu, X.H. and Li, Z.B., Chinese J. Polym. Sci., 2015, 33(8):1140 doi: 10.1007/s10118-015-1640-0
14. [14]
  Wang, X., Li, D., Yang, F., Shen, H., Li, Z. and Wu, D., Polym. Chem., 2013, 4(17):4596 doi: 10.1039/c3py00811h
15. [15]
  Bo, G.C., Min, H.P., Cho, S.H., Min, K.J., Oh, H.J., Kim, E.H., Park, K., Dong, K.H. and Jeong, B., Biomaterials, 2010, 31(35):9266 doi: 10.1016/j.biomaterials.2010.08.067
16. [16]
  Fan, Z., Zhang, Y., Ji, J. and Li, X., RSC Adv., 2015, 5(22):16740 doi: 10.1039/C4RA16490C
17. [17]
  Huang, J., Hastings, C.L., Duffy, G.P., Kelly, H.M., Raeburn, J., Adams, D.J. and Heise, A., Biomacromolecules, 2013, 14(1):200 doi: 10.1021/bm301629f
18. [18]
  Liu, D.L., Chang, X. and Dong, C.M., Chem. Commun., 2013, 49(12):1229 doi: 10.1039/c2cc38343h
19. [19]
  Fu, X.H., Ma, Y.N., Sun, J. and Li, Z.B., Chinese J. Polym. Sci., 2016, 34(12):1436 doi: 10.1007/s10118-016-1861-x
20. [20]
  Cheng, Y., He, C., Ding, J., Xiao, C., Zhuang, X. and Chen, X., Biomaterials, 2013, 34(38):10338 doi: 10.1016/j.biomaterials.2013.09.064
21. [21]
  Min, H.P., Min, K.J., Bo, G.C. and Jeong, B., Acc. Chem. Res., 2012, 45(3):424 doi: 10.1021/ar200162j
22. [22]
  Chen, C., Wang, Z. and Li, Z., Biomacromolecules, 2011, 12(8):2859 doi: 10.1021/bm200849m
23. [23]
  Zhang, S., Fu, W. and Li, Z., Polym. Chem., 2014, 5(10):3346 doi: 10.1039/C4PY00016A
24. [24]
  Chen, C., Wu, D., Fu, W. and Li, Z., Biomacromolecules, 2013, 14(8):2494 doi: 10.1021/bm4008259
25. [25]
  Cui, H., Zhuang, X., He, C., Wei, Y. and Chen, X., Acta Biomater., 2015, 11(1):183
26. [26]
  Yang, Z., Zhang, Y., Markland, P. and Yang, V.C., J. Biomed. Mater. Res., 2002, 62(1):14 doi: 10.1002/(ISSN)1097-4636
27. [27]
  Yi, C., Pang, X.H. and Dong, C.M., Adv. Funct. Mater., 2010, 20(4):579 doi: 10.1002/adfm.v20:4
28. [28]
  Wan, Y., Liu, L., Yuan, S., Sun, J. and Li, Z., Langmuir, 2017, 33(13):3234 doi: 10.1021/acs.langmuir.6b03986
29. [29]
  Fu, X., Ma, Y., Sun, J. and Li, Z., RSC Adv., 2016, 6(74):70243 doi: 10.1039/C6RA17427B
30. [30]
  Krannig, K.S., Sun, J. and Schlaad, H., Biomacromolecules, 2014, 15(3):978 doi: 10.1021/bm401883p
31. [31]
  Sun, J., Černoch, P., Völkel, A., Wei, Y., Ruokolainen, J. and Schlaad, H., Macromolecules, 2016, 49(15), 5494 doi: 10.1021/acs.macromol.6b00817
32. [32]
  Kang, E.Y., Yeon, B., Moon, H.J. and Jeong, B., Macromolecules, 2012, 45(4):2007 doi: 10.1021/ma202809c
33. [33]
  Meng, F., Fu, X., Sun, J. and Li, Z., Polymer, 2017, 118:173 doi: 10.1016/j.polymer.2017.04.059
34. [34]
  Greenfield, N. and Fasman, G.D., Biochemistry, 1969, 8(10):4108 doi: 10.1021/bi00838a031
35. [35]
  Vacogne, C.D., Schopferer, M. and Schlaad, H., Biomacromolecules, 2016, 17(7):2384 doi: 10.1021/acs.biomac.6b00427
36. [36]
  Kukula, H., Schlaad, H., Antonietti, M. and Förster, S., J. Am. Chem. Soc., 2002, 124(8):1658 doi: 10.1021/ja012091l
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