Citation: Fan-dong Meng, Yun-xia Ni, Si-fan Ji, Xiao-hui Fu, Yu-han Wei, Jing Sun, Zhi-bo Li. Dual Thermal-and pH-responsive Polypeptide-based Hydrogels[J]. Chinese Journal of Polymer Science, ;2017, 35(10): 1243-1252. doi: 10.1007/s10118-017-1959-9 shu

Dual Thermal-and pH-responsive Polypeptide-based Hydrogels

School of Polymer Science and Engineering, Qingdao University of Science and Technology, Qingdao 266042, China

Corresponding author: Jing Sun, jingsun@qust.edu.cn Zhi-bo Li, zbli@qust.edu.cn
Received Date: 7 April 2017
Revised Date: 26 April 2017
Accepted Date: 26 April 2017

Fund Project: the National Natural Science Foundation of China 21434008Natural Science Foundation of Shandong Province ZR2015EM015the National Natural Science Foundation of China 51225306

Smart hydrogels have received increasing attention for their great potential for the applications in many fields. Herein, we report a facile approach to prepare a class of dual-responsive hydrogels assembled from synthetic statistical/block thermal-responsive copoly(L-glutamate)s copolymerized with poly(ethylene glycol), which were prepared by ring-opening polymerization (ROP) and post-modification strategy. The incorporation of oligo(ethylene glycol) (OEG) and glutamic acid residues offers the gels with thermal- and pH-responsive properties simultaneously. We have systematically studied the influence of both temperature and pH on the gelation behaviors of these copolymers. It is found that the increase of glutamic acid content and solution pH values can significantly suppress the gelation ability of the samples. Circular dichroism (CD) results show that the α-helix conformation appears to be the dominant secondary conformation. More interestingly, the gelation property of the block copolymer with statistical thermal-responsive copoly(L-glutamate)s shows greater dependence on pH as compared to that with block segments due to the distinct morphology of the self-assemblies. The obtained hydrogels exhibit pH-dependent and thermal-responsive gelation behaviors, which enable them as an ideal smart hydrogel system for biomedical applications.
- pH-responsive,
- Thermal-responsive,
- Hydrogel,
- Polypeptide
1. [1]
  Kopecek, J., Biomaterials, 2007, 28(34):5185 doi: 10.1016/j.biomaterials.2007.07.044
2. [2]
  Li, Y., Rodrigues, J. and Tomas, H., Chem. Soc. Rev., 2011, 41(6):2193
3. [3]
  Nowak, A.P., Breedveld, V., Pakstis, L., Ozbas, B., Pine, D.J., Pochan, D. and Deming, T.J., Nature, 2002, 417(6887):424 doi: 10.1038/417424a
4. [4]
  Wright, E.R., Mcmillan, R.A., Cooper, A., Apkarian, R.P. and Conticello, V.P., Adv. Funct. Mater., 2002, 12(2):149 doi: 10.1002/(ISSN)1616-3028
5. [5]
  Yu, L. and Ding, J., Chem. Soc. Rev., 2008, 37(8):1473 doi: 10.1039/b713009k
6. [6]
  Chan, T.R., Stahl, P.J. and Yu, S.M., Adv. Funct. Mater., 2011, 21(22):4252 doi: 10.1002/adfm.201101163
7. [7]
  Nagarkar, P.R., Hule, A.R., Pochan, J.D. and Schneider, P.J., J. Am. Chem. Soc., 2008, 130(13):4466 doi: 10.1021/ja710295t
8. [8]
  Deming, T.J., Prog. Polym. Sci., 2007, 32(8-9):858 doi: 10.1016/j.progpolymsci.2007.05.010
9. [9]
  Shen, Y., Fu, X., Fu, W. and Li, Z., Chem. Soc. Rev., 2015, 44:612 doi: 10.1039/C4CS00271G
10. [10]
  Altunbas, A. and Pochan, D.J., Top. Curr. Chem., 2011, 310(5):135
11. [11]
  Yan, C. and Pochan, D.J., Chem. Soc. Rev., 2010, 39(9):3528 doi: 10.1039/b919449p
12. [12]
  Charati, M.B., Lee, I., Hribar, K.C. and Burdick, J.A., Small, 2010, 6(15):1608 doi: 10.1002/smll.v6:15
13. [13]
  Wu, L.Y., Yu, L., Fu, X.H. and Li, Z.B., Chinese J. Polym. Sci., 2015, 33(8):1140 doi: 10.1007/s10118-015-1640-0
14. [14]
  Wang, X., Li, D., Yang, F., Shen, H., Li, Z. and Wu, D., Polym. Chem., 2013, 4(17):4596 doi: 10.1039/c3py00811h
15. [15]
  Bo, G.C., Min, H.P., Cho, S.H., Min, K.J., Oh, H.J., Kim, E.H., Park, K., Dong, K.H. and Jeong, B., Biomaterials, 2010, 31(35):9266 doi: 10.1016/j.biomaterials.2010.08.067
16. [16]
  Fan, Z., Zhang, Y., Ji, J. and Li, X., RSC Adv., 2015, 5(22):16740 doi: 10.1039/C4RA16490C
17. [17]
  Huang, J., Hastings, C.L., Duffy, G.P., Kelly, H.M., Raeburn, J., Adams, D.J. and Heise, A., Biomacromolecules, 2013, 14(1):200 doi: 10.1021/bm301629f
18. [18]
  Liu, D.L., Chang, X. and Dong, C.M., Chem. Commun., 2013, 49(12):1229 doi: 10.1039/c2cc38343h
19. [19]
  Fu, X.H., Ma, Y.N., Sun, J. and Li, Z.B., Chinese J. Polym. Sci., 2016, 34(12):1436 doi: 10.1007/s10118-016-1861-x
20. [20]
  Cheng, Y., He, C., Ding, J., Xiao, C., Zhuang, X. and Chen, X., Biomaterials, 2013, 34(38):10338 doi: 10.1016/j.biomaterials.2013.09.064
21. [21]
  Min, H.P., Min, K.J., Bo, G.C. and Jeong, B., Acc. Chem. Res., 2012, 45(3):424 doi: 10.1021/ar200162j
22. [22]
  Chen, C., Wang, Z. and Li, Z., Biomacromolecules, 2011, 12(8):2859 doi: 10.1021/bm200849m
23. [23]
  Zhang, S., Fu, W. and Li, Z., Polym. Chem., 2014, 5(10):3346 doi: 10.1039/C4PY00016A
24. [24]
  Chen, C., Wu, D., Fu, W. and Li, Z., Biomacromolecules, 2013, 14(8):2494 doi: 10.1021/bm4008259
25. [25]
  Cui, H., Zhuang, X., He, C., Wei, Y. and Chen, X., Acta Biomater., 2015, 11(1):183
26. [26]
  Yang, Z., Zhang, Y., Markland, P. and Yang, V.C., J. Biomed. Mater. Res., 2002, 62(1):14 doi: 10.1002/(ISSN)1097-4636
27. [27]
  Yi, C., Pang, X.H. and Dong, C.M., Adv. Funct. Mater., 2010, 20(4):579 doi: 10.1002/adfm.v20:4
28. [28]
  Wan, Y., Liu, L., Yuan, S., Sun, J. and Li, Z., Langmuir, 2017, 33(13):3234 doi: 10.1021/acs.langmuir.6b03986
29. [29]
  Fu, X., Ma, Y., Sun, J. and Li, Z., RSC Adv., 2016, 6(74):70243 doi: 10.1039/C6RA17427B
30. [30]
  Krannig, K.S., Sun, J. and Schlaad, H., Biomacromolecules, 2014, 15(3):978 doi: 10.1021/bm401883p
31. [31]
  Sun, J., Černoch, P., Völkel, A., Wei, Y., Ruokolainen, J. and Schlaad, H., Macromolecules, 2016, 49(15), 5494 doi: 10.1021/acs.macromol.6b00817
32. [32]
  Kang, E.Y., Yeon, B., Moon, H.J. and Jeong, B., Macromolecules, 2012, 45(4):2007 doi: 10.1021/ma202809c
33. [33]
  Meng, F., Fu, X., Sun, J. and Li, Z., Polymer, 2017, 118:173 doi: 10.1016/j.polymer.2017.04.059
34. [34]
  Greenfield, N. and Fasman, G.D., Biochemistry, 1969, 8(10):4108 doi: 10.1021/bi00838a031
35. [35]
  Vacogne, C.D., Schopferer, M. and Schlaad, H., Biomacromolecules, 2016, 17(7):2384 doi: 10.1021/acs.biomac.6b00427
36. [36]
  Kukula, H., Schlaad, H., Antonietti, M. and Förster, S., J. Am. Chem. Soc., 2002, 124(8):1658 doi: 10.1021/ja012091l
1. [1]
  Jianye Kang , Xinyu Yang , Xuhao Yang , Jiahui Sun , Yuhang Liu , Shutao Wang , Wenlong Song . Carbon dots-enhanced pH-responsive lubricating hydrogel based on reversible dynamic covalent bondings. Chinese Chemical Letters, 2024, 35(5): 109297-. doi: 10.1016/j.cclet.2023.109297
2. [2]
  Yan Liu , Yang Wang , Jiayi Zhu , Xuxian Su , Xudong Lin , Liang Xu , Xiwen Xing . Employing pH-responsive RNA triplex to control CRISPR/Cas9-mediated gene manipulation in mammalian cells. Chinese Chemical Letters, 2024, 35(9): 109427-. doi: 10.1016/j.cclet.2023.109427
3. [3]
  Ningyue Xu , Jun Wang , Lei Liu , Changyang Gong . Injectable hydrogel-based drug delivery systems for enhancing the efficacy of radiation therapy: A review of recent advances. Chinese Chemical Letters, 2024, 35(8): 109225-. doi: 10.1016/j.cclet.2023.109225
4. [4]
  Ningning Gao , Yue Zhang , Zhenhao Yang , Lijing Xu , Kongyin Zhao , Qingping Xin , Junkui Gao , Junjun Shi , Jin Zhong , Huiguo Wang . Ba²⁺/Ca²⁺ co-crosslinked alginate hydrogel filtration membrane with high strength, high flux and stability for dye/salt separation. Chinese Chemical Letters, 2024, 35(5): 108820-. doi: 10.1016/j.cclet.2023.108820
5. [5]
  Rui Wang , He Qi , Haijiao Zheng , Qiong Jia . Light/pH dual-responsive magnetic metal-organic frameworks composites for phosphorylated peptide enrichment. Chinese Chemical Letters, 2024, 35(7): 109215-. doi: 10.1016/j.cclet.2023.109215
6. [6]
  Qiang Zhou , Pingping Zhu , Wei Shao , Wanqun Hu , Xuan Lei , Haiyang Yang . Innovative Experimental Teaching Design for 3D Printing High-Strength Hydrogel Experiments. University Chemistry, 2024, 39(6): 264-270. doi: 10.3866/PKU.DXHX202310064
7. [7]
  Qingyang Cui , Feng Yu , Zirun Wang , Bangkun Jin , Wanqun Hu , Wan Li . From Jelly to Soft Matter: Preparation and Properties-Exploring of Different Kinds of Hydrogels. University Chemistry, 2024, 39(9): 338-348. doi: 10.3866/PKU.DXHX202309046
8. [8]
  Pei Cao , Yilan Wang , Lejian Yu , Miao Wang , Liming Zhao , Xu Hou . Dynamic asymmetric mechanical responsive carbon nanotube fiber for ionic logic gate. Chinese Chemical Letters, 2024, 35(6): 109421-. doi: 10.1016/j.cclet.2023.109421
9. [9]
  Yong-Dan Zhao , Yidan Wang , Rongrong Wang , Lina Chen , Hengtong Zuo , Xi Wang , Jihong Qiang , Geng Wang , Qingxia Li , Canqi Ping , Shuqiu Zhang , Hao Wang . Reversing artemisinin resistance by leveraging thermo-responsive nanoplatform to downregulating GSH. Chinese Chemical Letters, 2024, 35(6): 108929-. doi: 10.1016/j.cclet.2023.108929
10. [10]
  Hailong He , Wenbing Wang , Wenmin Pang , Chen Zou , Dan Peng . Double stimulus-responsive palladium catalysts for ethylene polymerization and copolymerization. Chinese Chemical Letters, 2024, 35(7): 109534-. doi: 10.1016/j.cclet.2024.109534
11. [11]
  Haijing Cui , Weihao Zhu , Chuning Yue , Ming Yang , Wenzhi Ren , Aiguo Wu . Recent progress of ultrasound-responsive titanium dioxide sonosensitizers in cancer treatment. Chinese Chemical Letters, 2024, 35(10): 109727-. doi: 10.1016/j.cclet.2024.109727
12. [12]
  Xiaoliu Liang , Chunliu Huang , Hui Liu , Hu Chen , Jiabao Shou , Hongwei Cheng , Gang Liu . Natural hydrogel dressings in wound care: Design, advances, and perspectives. Chinese Chemical Letters, 2024, 35(10): 109442-. doi: 10.1016/j.cclet.2023.109442
13. [13]
  Yiran Tao , Chunlei Dai , Zhaoxiang Xie , Xinru You , Kaiwen Li , Jun Wu , Hai Huang . Redox responsive polymeric nanoparticles enhance the efficacy of cyclin dependent kinase 7 inhibitor for enhanced treatment of prostate cancer. Chinese Chemical Letters, 2024, 35(8): 109170-. doi: 10.1016/j.cclet.2023.109170
14. [14]
  Jingqi Xin , Shupeng Han , Meichen Zheng , Chenfeng Xu , Zhongxi Huang , Bin Wang , Changmin Yu , Feifei An , Yu Ren . A nitroreductase-responsive nanoprobe with homogeneous composition and high loading for preoperative non-invasive tumor imaging and intraoperative guidance. Chinese Chemical Letters, 2024, 35(7): 109165-. doi: 10.1016/j.cclet.2023.109165
15. [15]
  Jingting Wang , Yuanyuan Chen , Linlin Han , Shasha Xia , Xingyao Zhang , Peng Xue , Yuejun Kang , Jian Ming , Zhigang Xu . Microenvironment responsive pod-structured astaxanthin nanocarrier for ameliorating inflammatory bowel disease. Chinese Chemical Letters, 2024, 35(7): 109029-. doi: 10.1016/j.cclet.2023.109029
16. [16]
  Ling-Ling Wu , Xiangchuan Meng , Qingyang Zhang , Xiaowan Han , Feiya Yang , Qinghua Wang , Hai-Yu Hu , Nianzeng Xing . Heavy-atom engineered hypoxia-responsive probes for precisive photoacoustic imaging and cancer therapy. Chinese Chemical Letters, 2024, 35(4): 108663-. doi: 10.1016/j.cclet.2023.108663
17. [17]
  Liangji Chen , Zhen Yuan , Fudong Feng , Xin Zhou , Zhile Xiong , Wuji Wei , Hao Zhang , Banglin Chen , Shengchang Xiang , Zhangjing Zhang . A hydrogen-bonded organic framework containing fluorescent carbazole and responsive pyridyl units for sensing organic acids. Chinese Chemical Letters, 2024, 35(9): 109344-. doi: 10.1016/j.cclet.2023.109344
18. [18]
  Jinyu Guo , Yandai Lin , Shaohua He , Yueqing Chen , Fenglu Li , Renjie Ruan , Gaoxing Pan , Hexin Nan , Jibin Song , Jin Zhang . Utilizing dual-responsive iridium(Ⅲ) complex for hepatocellular carcinoma: Integrating photoacoustic imaging with chemotherapy and photodynamic therapy. Chinese Chemical Letters, 2024, 35(9): 109537-. doi: 10.1016/j.cclet.2024.109537
19. [19]
  Chun-Yun Ding , Ru-Yuan Zhang , Yu-Wu Zhong , Jiannian Yao . Binary and heterostructured microplates of iridium and ruthenium complexes: Preparation, characterization, and thermo-responsive emission. Chinese Journal of Structural Chemistry, 2024, 43(10): 100393-100393. doi: 10.1016/j.cjsc.2023.100393
20. [20]
  Huan Hu , Ying Zhang , Shi-Shuang Huang , Zhi-Gang Li , Yungui Liu , Rui Feng , Wei Li . Temperature- and pressure-responsive photoluminescence in a 1D hybrid lead halide. Chinese Journal of Structural Chemistry, 2024, 43(10): 100395-100395. doi: 10.1016/j.cjsc.2024.100395

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(725)
HTML views(20)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142