Citation: Le-yuan Song, Ni Jiang, Zhi-hua Gan. Surface Treatment and Biomimetic Mineralization of Porous Microspheres Fabricated by Calcium Gluconate-g-Poly(D, L-lactide)[J]. Chinese Journal of Polymer Science, ;2017, 35(7): 837-845. doi: 10.1007/s10118-017-1940-7 shu

Surface Treatment and Biomimetic Mineralization of Porous Microspheres Fabricated by Calcium Gluconate-g-Poly(D, L-lactide)

State Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China

Corresponding author: Ni Jiang, jiangni@mail.buct.edu.cn Zhi-hua Gan, zhgan@mail.buct.edu.cn
Received Date: 17 November 2016
Revised Date: 5 December 2016
Accepted Date: 6 December 2016

Fund Project: the Fundamental Research Funds for the Central Universities ZY1632the National Natural Science Foundation of China 21104089the National Natural Science Foundation of China 51025314

Porous hybrid microspheres were fabricated by the synthesized calcium gluconate-g-poly(D, L-lactide) (CG-g-PDLLA) composites. These hybrid microspheres were treated with an alkaline solution for different period of time to control the amount of generated carboxylate groups and remained CG on the surface. The microspheres were then incubated in a supersaturated simulated body fluid (1.5 SBF) solution for different time to investigate their biomimetic mineralization behavior. The depositions were found to have a fine cluster morphology, a similar crystal structure and chemical structure to natural hydroxyapatite, and a medium Ca/P of approximately 1.30. The effect of surface treating time on the structure and mineralization behavior of these microspheres has been discussed in detail. The results indicate that the nucleation and growth of apatite on the surface are influenced by the induced carboxylate groups and the remained CG. The hybrid CG-g-PDLLA microspheres have the potential as a novel alternative in bone tissue engineering.
- Calcium gluconate,
- Poly (D, L-lactide),
- Mineralization,
- Hydroxyapatite,
- Porous microspheres
1. [1]
  Kim, T.G., Shin, H. and Lim, D.W., Adv. Funct. Mater., 2012, 22: 2446 doi: 10.1002/adfm.201103083
2. [2]
  Almubarak, S., Nethercott, H., Freeberg, M., Beaudon, C., Jha, A., Jackson, W., Marcucio, R., Miclau, T., Healy, K. and Bahney, C., Bone, 2016, 83: 197 doi: 10.1016/j.bone.2015.11.011
3. [3]
  Schindeler, A., IBMS BoneKEy, 2012, 9: 1 doi: 10.1038/bonekey.2012.203
4. [4]
  Zaffagnini, S., Giordano, G., Vascellari, A., Bruni, D., Neri, M.P., Iacono, F., Kon, E., Presti, M.L. and Marcacci, M., Knee. Surg. Sport. Tr. A., 2007, 15: 175 doi: 10.1007/s00167-006-0144-4
5. [5]
  Zhou, H. and Lee, J., Acta Biomaterialia, 2011, 7: 2769 doi: 10.1016/j.actbio.2011.03.019
6. [6]
  Kijeńska, E., Prabhakaran, M.P., Swieszkowski, W., Kurzydlowski, K.J. and Ramakrishna, S., J. Biomed. Mater. Res. B., 2012, 100: 1093
7. [7]
  Krause, M., Keller, J., Beil, B., Driel, I., Zustin, J., Barvencik, F., Schinke, T. and Amling, M., Osteoporos. Int., 2015, 26: 987 doi: 10.1007/s00198-014-2965-1
8. [8]
  Liu, W., Yin, J., Qin, C., Feng, B. and Xu, M., Environ. Sci. Technol., 2012, 46: 11267 doi: 10.1021/es301783b
9. [9]
  Apelblat, A. and Manzurola, E., J. Chem. Thermodynamics, 2001, 33: 147 doi: 10.1006/jcht.2000.0735
10. [10]
  Manzurola, E. and Apelblat, A., J. Chem. Thermodynamics, 2002, 34: 1127 doi: 10.1006/jcht.2002.0975
11. [11]
  Shibli, S.M.A. and Mathai, S., J. Biomed. Mater. Res. B., 2008, 87A: 994 doi: 10.1002/jbm.a.v87a:4
12. [12]
  Hämäläinen, M.M., Knuuttila, M., Svanberg, M. and Koskinen, T., Bone, 1990, 11: 429 doi: 10.1016/8756-3282(90)90139-P
13. [13]
  Lahodny-Šarc, O. and Kapor, F., Mater. Corros., 2002, 53: 264 doi: 10.1002/(ISSN)1521-4176
14. [14]
  Liu, Y., Ghassemi, A.H., Hennink, W.E. and Schwendeman, S.P., Biomaterials, 2012, 33: 7584 doi: 10.1016/j.biomaterials.2012.06.013
15. [15]
  Moore, W.R., Graves, S.E. and Bain, G.I., ANZ. J. Surg., 2001, 71: 354 doi: 10.1046/j.1440-1622.2001.02128.x
16. [16]
  Li, J., Beaussart, A., Chen, Y. and Mak, A.F.T., J. Biomed. Mater. Res. A., 2007, 80A: 226 doi: 10.1002/(ISSN)1552-4965
17. [17]
  Murphy, W.L. and Mooney, D.J., J. Am. Chem. Soc., 2002, 124: 1910 doi: 10.1021/ja012433n
18. [18]
  Shi, X.D., Jiang, J., Sun, L. and Gan, Z.H., Colloids Surf. B Biointerfaces, 2011, 85: 73 doi: 10.1016/j.colsurfb.2010.11.016
19. [19]
  Chen, J., Chu, B. and Hsiao, B.S., J. Biomed. Mater. Res. A., 2006, 79: 307
20. [20]
  Kokubo, T. and Takadama, H., Biomaterials, 2006, 27: 2907 doi: 10.1016/j.biomaterials.2006.01.017
21. [21]
  Hartgerink, J.D., Beniash, E. and Stupp, S.I., Science, 2001, 294: 1684 doi: 10.1126/science.1063187
22. [22]
  Du, K., Shi, X.D. and Gan, Z.H., Langmuir, 2013, 29: 15293 doi: 10.1021/la404209u
23. [23]
  Wu, L.Y., Yu, L., Fu, X.H. and Li, Z.B., Chinese J. Polym. Sci., 2015, 33(8): 1140 doi: 10.1007/s10118-015-1640-0
24. [24]
  Wang, B., Yu, J. and Guo, Z.X., Chinese J. Polym. Sci., 2005, 23(4): 379 doi: 10.1142/S0256767905000539
25. [25]
  Kim, T.K., Yoon, J.J., Lee, D.S. and Park, T.G., Biomaterials, 2006, 27: 152 doi: 10.1016/j.biomaterials.2005.05.081
26. [26]
  Wang, S.Y., Shi, X.D., Gan, Z.H. and Wang, F., Chinese J. Polym. Sci., 2015, 33(1): 128 doi: 10.1007/s10118-014-1507-9
27. [27]
  Cao, H., Zhang, L., Zheng, H. and Wang, Z., J. Phys. Chem. C., 2010, 114: 18352 doi: 10.1021/jp106078b
28. [28]
  Li, C., Born, A., Schweizer, T., Zenobi-Wong, M., Cerruti, M. and Mezzenga, R., Adv. Mater., 2014, 26: 3207 doi: 10.1002/adma.v26.20
29. [29]
  Hutchens, S.A., Benson, R.S., Evans, B.R., O'Neill, H.M. and Rawn, C.J., Biomaterials, 2006, 27: 4661 doi: 10.1016/j.biomaterials.2006.04.032
30. [30]
  Prieto, S., Shkilnyy, A., Rumplasch, C., Ribeiro, A., Arias, F.J., Rodriguez-Cabello, J.C. and Taubert, A., Biomacromolecules, 2011, 12: 1480 doi: 10.1021/bm200287c
31. [31]
  Lao, L., Wang, Y., Zhu, Y., Zhang, Y. and Gao, C., J. Mater. Sci-Mater. M., 2011, 22: 1873 doi: 10.1007/s10856-011-4374-8
1. [1]
  Long Li , Kang Yang , Chenpeng Xi , Mengchao Li , Borong Li , Gui Xu , Yuanbin Xiao , Xiancai Cui , Zhiliang Liu , Lingyun Li , Yan Yu , Chengkai Yang . Highly-chlorinated inert and robust interphase without mineralization of oxide enhancing high-rate Li metal batteries. Chinese Chemical Letters, 2024, 35(6): 108814-. doi: 10.1016/j.cclet.2023.108814
2. [2]
  Yuhan Wu , Qing Zhao , Zhijie Wang . Layered vanadium oxides: Promising cathode materials for calcium-ion batteries. Chinese Journal of Structural Chemistry, 2024, 43(5): 100271-100271. doi: 10.1016/j.cjsc.2024.100271
3. [3]
  Lishan Xiong , Xinyuan Li , Xiaojie Lu , Zhendong Zhang , Yan Zhang , Wen Wu , Chenhui Wang . Inhaled multilevel size-tunable, charge-reversible and mucus-traversing composite microspheres as trojan horse: Enhancing lung deposition and tumor penetration. Chinese Chemical Letters, 2024, 35(9): 109384-. doi: 10.1016/j.cclet.2023.109384
4. [4]
  Xinyu You , Xin Zhang , Shican Jiang , Yiru Ye , Lin Gu , Hexun Zhou , Pandong Ma , Jamal Ftouni , Abhishek Dutta Chowdhury . Efficacy of Ca/ZSM-5 zeolites derived from precipitated calcium carbonate in the methanol-to-olefin process. Chinese Journal of Structural Chemistry, 2024, 43(4): 100265-100265. doi: 10.1016/j.cjsc.2024.100265
5. [5]
  Shiyu Pan , Bo Cao , Deling Yuan , Tifeng Jiao , Qingrui Zhang , Shoufeng Tang . Complexes of cupric ion and tartaric acid enhanced calcium peroxide Fenton-like reaction for metronidazole degradation. Chinese Chemical Letters, 2024, 35(7): 109185-. doi: 10.1016/j.cclet.2023.109185
6. [6]
  Ziyi Zhu , Yang Cao , Jun Zhang . CO2-switched porous metal-organic framework magnets. Chinese Journal of Structural Chemistry, 2024, 43(2): 100241-100241. doi: 10.1016/j.cjsc.2024.100241
7. [7]
  Chao Ma , Cong Lin , Jian Li . MicroED as a powerful technique for the structure determination of complex porous materials. Chinese Journal of Structural Chemistry, 2024, 43(3): 100209-100209. doi: 10.1016/j.cjsc.2023.100209
8. [8]
  Uttam Pandurang Patil . Porous carbon catalysis in sustainable synthesis of functional heterocycles: An overview. Chinese Chemical Letters, 2024, 35(8): 109472-. doi: 10.1016/j.cclet.2023.109472
9. [9]
  Zixuan Guo , Xiaoshuai Han , Chunmei Zhang , Shuijian He , Kunming Liu , Jiapeng Hu , Weisen Yang , Shaoju Jian , Shaohua Jiang , Gaigai Duan . Activation of biomass-derived porous carbon for supercapacitors: A review. Chinese Chemical Letters, 2024, 35(7): 109007-. doi: 10.1016/j.cclet.2023.109007
10. [10]
  Yi Cao , Xiaojiao Ge , Yuanyuan Wei , Lulu He , Aiguo Wu , Juan Li . Tumor microenvironment-activatable neuropeptide-drug conjugates enhanced tumor penetration and inhibition via multiple delivery pathways and calcium deposition. Chinese Chemical Letters, 2024, 35(4): 108672-. doi: 10.1016/j.cclet.2023.108672
11. [11]
  Wenda WANG , Jinku MA , Yuzhu WEI , Shuaishuai MA . Waste biomass-derived carbon modified porous graphite carbon nitride heterojunction for efficient photodegradation of oxytetracycline in seawater. Chinese Journal of Inorganic Chemistry, 2024, 40(4): 809-822. doi: 10.11862/CJIC.20230353
12. [12]
  Peng Zhou , Ziang Jiang , Yang Li , Peng Xiao , Feixiang Wu . Sulphur-template method for facile manufacturing porous silicon electrodes with enhanced electrochemical performance. Chinese Chemical Letters, 2024, 35(8): 109467-. doi: 10.1016/j.cclet.2023.109467
13. [13]
  Yuchen Wang , Yaoyu Liu , Xiongfei Huang , Guanjie He , Kai Yan . Fe nanoclusters anchored in biomass waste-derived porous carbon nanosheets for high-performance supercapacitor. Chinese Chemical Letters, 2024, 35(8): 109301-. doi: 10.1016/j.cclet.2023.109301
14. [14]
  Xiaxia Xing , Xiaoyu Chen , Zhenxu Li , Xinhua Zhao , Yingying Tian , Xiaoyan Lang , Dachi Yang . Polyethylene imine functionalized porous carbon framework for selective nitrogen dioxide sensing with smartphone communication. Chinese Chemical Letters, 2024, 35(9): 109230-. doi: 10.1016/j.cclet.2023.109230
15. [15]
  Xinyi Cao , Yucheng Jin , Hailong Wang , Xu Ding , Xiaolin Liu , Baoqiu Yu , Xiaoning Zhan , Jianzhuang Jiang . A tetraaldehyde-derived porous organic cage and covalent organic frameworks: Syntheses, structures, and iodine vapor capture. Chinese Chemical Letters, 2024, 35(9): 109201-. doi: 10.1016/j.cclet.2023.109201
16. [16]
  Si-Hua Liu , Jun-Hao Zhou , Jian-Ke Sun . Interconnecting zero-dimensional porous organic cages into sub-8 nm nanofilm for bio-inspired separation. Chinese Journal of Structural Chemistry, 2024, 43(7): 100312-100312. doi: 10.1016/j.cjsc.2024.100312
17. [17]
  Zeyu XU , Tongzhou LU , Haibo SHAO , Jianming WANG . Preparation and electrochemical lithium storage performance of porous silicon microsphere composite with metal modification and carbon coating. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1995-2008. doi: 10.11862/CJIC.20240164
18. [18]
  Haojie Song , Laiyu Luo , Siyu Wang , Guo Zhang , Baojiang Jiang . Advances in poly(heptazine imide)/poly(triazine imide) photocatalyst. Chinese Chemical Letters, 2024, 35(10): 109347-. doi: 10.1016/j.cclet.2023.109347
19. [19]
  Ya Song , Mingxia Zhou , Zhu Chen , Huali Nie , Jiao-Jing Shao , Guangmin Zhou . Integrated interconnected porous and lamellar structures realized fast ion/electron conductivity in high-performance lithium-sulfur batteries. Chinese Chemical Letters, 2024, 35(6): 109200-. doi: 10.1016/j.cclet.2023.109200
20. [20]
  Yuting Wu , Haifeng Lv , Xiaojun Wu . Design of two-dimensional porous covalent organic framework semiconductors for visible-light-driven overall water splitting: A theoretical perspective. Chinese Journal of Structural Chemistry, 2024, 43(11): 100375-100375. doi: 10.1016/j.cjsc.2024.100375

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(615)
HTML views(36)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142