Citation: Xiang-ru Feng, Jian-xun Ding, Ruxandra Gref, Xue-si Chen. Poly(β-cyclodextrin)-mediated Polylactide-cholesterol Stereocomplex Micelles for Controlled Drug Delivery[J]. Chinese Journal of Polymer Science, ;2017, 35(6): 693-699. doi: 10.1007/s10118-017-1932-7 shu

Poly(β-cyclodextrin)-mediated Polylactide-cholesterol Stereocomplex Micelles for Controlled Drug Delivery

a.
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
b.
Institute of Molecular Sciences, CNRS, Université Paris-Sud, Université Paris Saclay, Orsay 91400, France

Corresponding author: Jian-xun Ding, jxding@caic.ac.cn Ruxandra Gref, ruxandra.gref@u-psud.fr
Received Date: 27 December 2016
Revised Date: 20 January 2017
Accepted Date: 23 January 2017

Fund Project: financially supported by the National Natural Science Foundation of China 51673190financially supported by the National Natural Science Foundation of China 51303174financially supported by the National Natural Science Foundation of China 51390484financially supported by the National Natural Science Foundation of China 51603204

A series of host-guest interaction-adjusted polylactide stereocomplex micelles was prepared via the self-assembly of 4-armed poly(ethylene glycol)-block-poly(L-lactide/D-lactide)-cholesterol (4-armed PEG-b-PLLA/PDLA-CHOL) and poly(β-cyclodextrin) (PCD) with the molar ratios of CHOL/β-CD at 1:0.5, 1:1, and 1:2 in an aqueous environment. The hydrodynamic diameters of the micelles ranged from 84.1 nm to 107 nm depending on the molar ratio of CHOL/β-CD. It was shown that the micelle with the largest proportion of PCD possessed excellent abilities in drug release, cell internalization as well as proliferation inhibitory effect toward human A549 lung cancer cells. The results demonstrated that the stereocomplex and host-guest interactions-mediated PLA micelles exhibited great potential in sustained drug delivery.
- Polylactide,
- Stereocomplex micelle,
- Poly(β-cyclodextrin),
- Host-guest interaction,
- Controlled drug delivery
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1.
沈阳化工大学材料科学与工程学院沈阳 110142