Citation: Xiao-ju Lu, Xiang-yu Yang, Yuan Meng, Shao-zhen Li. Temperature and pH Dually-responsive Poly (β-amino ester) Nanoparticles for Drug Delivery[J]. Chinese Journal of Polymer Science, ;2017, 35(4): 534-546. doi: 10.1007/s10118-017-1916-7 shu

Temperature and pH Dually-responsive Poly (β-amino ester) Nanoparticles for Drug Delivery

School of Chemical and Material Engineering and Institute of Quantum Materials, Hubei Polytechnic University, Huangshi 435003, China

Corresponding author: Xiao-ju Lu, xiaoju_lu@163.com
Received Date: 11 August 2016
Revised Date: 21 October 2016
Accepted Date: 22 October 2016

Fund Project: the Science Foundation from Hubei Polytechnic University 12xjz08Rthe Science Foundation from Hubei Polytechnic University 801-8596the National Natural Science Foundation of China 51402099Education Foundation of Hubei Province T201521

Stimuli-responsive polymers have undoubtedly been of great interest in the past decades due to a variety of their potential applications in biomedical territory. However, their non-degradability limits their in vivo applications. Herein, we report a novel pH and temperature dual-stimuli responsive-poly (β-amino ester). The pH/temperature sensitivities are interrelated and can be easily tuned by changing PEG-diacrylate chain length and the percentage of biamines in the feed ratio. These dual-responsive polymers are very useful in drug delivery. Reaction of methyl ether poly (ethylene glycol) (MPEG) and poly (β-amino ester) resulted in an amphiphilic MPEG-PBAE block copolymer which could form nanoparticles by self-assembly. A hydrophobic drug (DOX) was loaded in the self-assembled nanoparticles at low temperature without using organic solvents. The loaded drug was released very slowly and steadily at 37℃ under physiological conditions (pH 7.4), but rapidly released from the micelles in weakly acidic environments (pH 6.4 and 5.0) for intracellular drug release. Thus, these poly (β-amino ester) polymers constitute ideal drug carriers since their thermal sensitivity allows the drug loadings without using organic solvent and their pH sensitivity permits fast intracellular drug release.
- Temperature-sensitive,
- pH-sensitive,
- Nanoparticles,
- Drug delivery
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