Citation: Xiao-rong Wu, Chen-wei Wu, Chuan Zhang. Discrete DNA Three-dimensional Nanostructures: the Synthesis and Applications[J]. Chinese Journal of Polymer Science, ;2017, 35(1): 1-24. doi: 10.1007/s10118-017-1871-3 shu

Discrete DNA Three-dimensional Nanostructures: the Synthesis and Applications

School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Key Laboratory of Electrical Insulation and Thermal Ageing, Shanghai Jiao Tong University, Shanghai 200240, China

Corresponding author: Chuan Zhang, chuanzhang@sjtu.edu.cn
Received Date: 11 August 2016
Revised Date: 30 August 2016
Accepted Date: 15 September 2016

Fund Project: the National Natural Science Foundation of China 21504053the Recruitment Program of Global Experts 15Z127060012

Structural DNA nanotechnology, an emerging technique that utilizes the nucleic acid molecule as generic polymer to programmably assemble well-defined and nano-sized architectures, holds great promise for new material synthesis and constructing functional nanodevices for different purposes. In the past three decades, rapid development of this technique has enabled the syntheses of hundreds and thousands of DNA nanostructures with various morphologies at different scales and dimensions. Among them, discrete three-dimensional (3D) DNA nanostructures not only represent the most advances in new material design, but also can serve as an excellent platform for many important applications. With precise spatial addressability and capability of arbitrary control over size, shape, and function, these nanostructures have drawn particular interests to scientists in different research fields. In this review article, we will briefly summarize the development regarding the synthesis of discrete DNA 3D nanostructures with various size, shape, geometry, and topology, including our previous work and recent progress by other groups. In detail, three methods majorly used to synthesize the DNA 3D objects will be introduced accordingly. Additionally, the principle, design rule, as well as pros and cons of each method will be highlighted. As functions of these discrete 3D nanostructures have drawn great interests to researchers, we will further discuss their cutting-edge applications in different areas, ranging from novel material synthesis, new device fabrication, and biomedical applications, etc. Lastly, challenges and outlook of these promising nanostructures will be given based on our point of view.
- DNA self-assembly,
- DNA 3D nanostructure,
- Nanocarrier,
- Biosensor,
- Nanomedicine
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沈阳化工大学材料科学与工程学院沈阳 110142