Citation: Xiao-hui Fu, Yi-nan Ma, Jing Sun, Zhi-bo Li. Thermal and Redox Dual Responsive Poly (L-glutamate) with Oligo (ethylene glycol) Side-chains[J]. Chinese Journal of Polymer Science, ;2016, 34(12): 1436-1447. doi: 10.1007/s10118-016-1861-x shu

Thermal and Redox Dual Responsive Poly (L-glutamate) with Oligo (ethylene glycol) Side-chains

Xiao-hui Fu ^a,b ,
Yi-nan Ma ^b ,
Jing Sun ^a,, ,
Zhi-bo Li ^a,b,,

a.
School of Polymer Science and Engineering, Qingdao University of Science and Technology, Qingdao 266042, China
b.
Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China

Corresponding author: Jing Sun, jingsun@qust.edu.cn Zhi-bo Li, zbli@qust.edu.cn
Received Date: 30 August 2016
Revised Date: 15 September 2016
Accepted Date: 15 September 2016

Fund Project: the National Natural Science Foundation of China 50821062the National Natural Science Foundation of China 20974112

A series of poly (L-glutamate) s grafted with oligo (ethylene glycol) (OEG) side-chains through the thioether linkages (PALG_n-g-EG_x, x=2, 3 and 4) were prepared by ring-opening polymerization (ROP) of γ-allyl-L-glutamate N-carboxyanhydride (ALG-NCA) and thiol-ene photoaddition. The chemical structures and physical properties were characterized by ¹H-NMR, Fourier transform infrared (FTIR), circular dichroism (CD), etc. The PALG_n-g-EG_x samples with x=3 and 4 displayed lower critical solution temperature (LCST) in water due to the presence of OEG units. The clouding point (CP) of polypeptides can be finely tuned by changing the side chain structures, molecular weights and sample concentrations. In addition, the thioether linkages in the side chains offer additional redox-responsive properties. The influence of both OEG units and thioether linkages on the LCST behavior was systematically investigated. This work provides an efficient way to prepare multi-stimuli responsive materials with highly tunable properties.
- N-carboxyanhydride (NCA),
- Polypeptide,
- Ring-opening polymerization,
- Click chemistry,
- Stimuli-responsive
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