Citation: Han Miao, Ya-fen Wang, Hai-yan Dong, Dao-yong Chen. Complexation Induced by Weak Interaction between DNA and PEO-b-P4VP below the CMC of the Polymer[J]. Chinese Journal of Polymer Science, ;2017, 35(1): 46-53. doi: 10.1007/s10118-016-1857-6 shu

Complexation Induced by Weak Interaction between DNA and PEO-b-P4VP below the CMC of the Polymer

The State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200433, China

Corresponding author: Dao-yong Chen, chendy@fudan.edu.cn
Received Date: 19 May 2016
Revised Date: 25 May 2016
Accepted Date: 25 May 2016

Fund Project: the National Natural Science Foundation of China 21334001

The complexation between circular DNA and individual chains of PEO-b-P4VP with a relatively long PEO block and a short P4VP block is highly controllable when the interaction between DNA and the polymer is weak enough. When one circular DNA chain is taken into consideration, and the polymer concentration is far below its critical micelle concentration (CMC), polymer chains are absorbed by DNA chain due to the interaction between the negatively charged DNA chain and the slightly positively charged P4VP block chains. After the adsorption/complexation, the DNA chain is converted into a nanoring (type 1). In the nanoring, the DNA chain is sufficiently wrapped by the polymer and adopts a fully stretched conformation, so that the DNA compact ratio in the nanorings is close to 1. When the polymer concentration is close to but lower than the CMC, the free polymer chains in the solution are adsorbed not only by the DNA chain but also by the polymer chains that have already been adsorbed on the DNA chain. As a result, the circular DNA chain adsorbs more polymer chains, and thus the resultant nanoring (type 2) has a larger width. In the type 2 nanoring, the DNA chain is slightly compressed; the DNA compact ratio is only about 2-3. Therefore, complexation induced by the weak interaction between DNA and PEO-b-P4VP below the CMC can produce narrow-disperse and large nanorings with a perimeter of micrometers, which are difficult to prepare by existing methods.
- Weak interaction,
- DNA,
- Individual polymer chains,
- Block copolymer,
- Critical micelle concentration
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