Citation: Chen Hu, Tian Xia, Ying Gong, Xin Wang, Ruan-qing Liu, Quan-yuan Zhang, Chang-feng Yi, Zu-shun Xu, Ding-zong Guo. Emulsifier-free Emulsion Polymerized Poly(MMA-HEMA-Eu(AA)3Phen)/Fe3O4 Magnetic Fluorescent Bifunctional Nanospheres for Magnetic Resonance and Optical Imaging[J]. Chinese Journal of Polymer Science, ;2016, 34(2): 135-146. doi: 10.1007/s10118-016-1739-y shu

Emulsifier-free Emulsion Polymerized Poly(MMA-HEMA-Eu(AA)3Phen)/Fe3O4 Magnetic Fluorescent Bifunctional Nanospheres for Magnetic Resonance and Optical Imaging

1.
Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry of Education Key Laboratory for The Green Preparation and Application of Functional Material, Hubei University, Wuhan 430062, China
2.
College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China

Received Date: 17 June 2015
Revised Date: 24 August 2015

Fund Project: This work was financially supported by the National Natural Science Foundation of China (No. 51273058) and in part, by the National Key Technology RD Program of China (No. 2012BAD12B03).

Integration of biocompatibility with superparamagnetic Fe3O4 nanoparticles and luminescence rare earth complexes Eu(AA)3Phen was carried out to form bifunctional nanospheres for using in bioimaging applications. The nanospheres Poly(MMA-HEMA-Eu(AA)3Phen)/Fe3O4 exhibit magnetic and fluorescent properties that are favorable for the use in drug delivery, magnetic separation and MR imaging for biomedical research. The TEM and SEM studies reveal that the bifunctional nanospheres have core-shell structure, in a spherical shape with a size ranging from 140 nm to 180 nm. In MRI experiments, a clear negative contrast enhancement in T2 images and the r2 reaches 568.82 (mmolL-1)-1s-1. In vivo magnetic and fluorescence resonance imaging results suggest the nanospheres are able to preferentially accumulate in liver and spleen tissues to allow dual-modal detection of cancer cells in a living body.
- Magnetic,
- Fluorescent,
- Bifunctional nanospheres,
- MR image
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沈阳化工大学材料科学与工程学院沈阳 110142