Citation: Yin Yuan, Pei-jian Sun, Xu-dong Shi, Zhi-hua Gan, Fo-song Wang. Biodegradable Microspheres with Poly(N-isopropylacrylamide) Enriched Surface: Thermo-responsibility, Biodegradation and Drug Release[J]. Chinese Journal of Polymer Science, ;2015, 33(11): 1598-1605. doi: 10.1007/s10118-015-1702-3 shu

Biodegradable Microspheres with Poly(N-isopropylacrylamide) Enriched Surface: Thermo-responsibility, Biodegradation and Drug Release

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CAS Key Laboratory of Engineering Plastics, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
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1. CAS Key Laboratory of Engineering Plastics, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
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2. State Key Laboratory of Organic-inorganic Composites, Beijing Laboratory of Biomedical Materials, College of Life Sciences and Technology, Beijing 100029, China
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Received Date: 23 April 2015
Revised Date: 28 April 2015

Fund Project: This work was financially supported by the National Natural Science Foundation of China (Nos. 51025314 and 51390481).

Microspheres with thermo-responsible surface were fabricated by PCL-b-PEO-b-PNIPAM triblock copolymers. Thermo-responsible morphological changes of PCL-b-PEO-b-PNIPAM microspheres immersed in aqueous solution at temperatures above the LCST (e.g. 37 ℃) were observed from porous surface structure to compact surface layer. Enzymatic degradation and in vitro drug release results showed that the thermo-responsible surface layer greatly influenced the degradation of microspheres as well as the drug release behavior from microspheres. With the copolymerization of PNIPAM block into PCL-b-PEO copolymers, the drug release could be well regulated by changing temperatures and microspheres composition, which revealed the great potentials of microspheres with thermo-responsible surface for controlled drug release.
- Microspheres,
- Poly(N-isopropylacrylamide),
- Thermo-sensitive,
- Biodegradation
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