Citation: Jing Liu, Zhi Yuan. Comparation of Activity against A Aggregation between RR and LPFFD[J]. Chinese Journal of Polymer Science, ;2015, 33(7): 1009-1017. doi: 10.1007/s10118-015-1646-7 shu

Comparation of Activity against A Aggregation between RR and LPFFD

Jing Liu ¹ ,
Zhi Yuan ¹

1.
Key Laboratory of Functional Polymer Materials of Ministry of Education, and Institute of Polymer Chemistry, Nankai University, and Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300071, China

Received Date: 30 October 2014
Revised Date: 7 January 2015

Fund Project: This work was financially supported by the National Natural Science Foundation of China (Nos. 20634030 and 51273094), State Key Fundamental RD Project (No. 2011CB606202), and PCSIRT (No. IRT1257).

Here, we introduce the design of the structure of RR (RYYAAFFARR), an inhibitor of A aggregation, using molecular docking, and compare the inhibitory ability between RR and LPFFD, which interacts with A mainly depending on hydrophobic interaction. Our results showed that RR which can target multiple regions of A with multiple weak interactions is better than those that only target a single region with the single driving force mainly.
- Molecular docking,
- Multiple weak interactions,
- Affinity,
- Inhibitory ability
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