Citation: Yi-fei Li, Hai-yang Yu, Hai Sun, Jian-guo Liu, Zhao-hui Tang, Dan Wang, Lian-you Yu, Xue-si Chen. Cisplatin-loaded Poly(L-glutamic acid)-g-Methoxy Poly(ethylene glycol) Nanoparticles as a Potential Chemotherapeutic Agent against Osteosarcoma[J]. Chinese Journal of Polymer Science, ;2015, 33(5): 763-771. doi: 10.1007/s10118-015-1624-0 shu

Cisplatin-loaded Poly(L-glutamic acid)-g-Methoxy Poly(ethylene glycol) Nanoparticles as a Potential Chemotherapeutic Agent against Osteosarcoma

Yi-fei Li ^1,2,3 ,
Hai-yang Yu ⁴ ,
Hai Sun ⁴ ,
Jian-guo Liu ⁵ ,
Zhao-hui Tang ⁴ ,
Dan Wang ⁶ ,
Lian-you Yu ⁷ ,
Xue-si Chen ⁴

1.
1. Departemnt of Orthopaedics, the Norman Bethune First Hospital of Jilin University, Changchun 130021, China
2.
2. Jilin Central Hospital, Jilin 132011, China
3.
4.
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
5.
Departemnt of Orthopaedics, the Norman Bethune First Hospital of Jilin University, Changchun 130021, China
6.
Basic Medical College, Beihua University, Jilin 132013, China
7.
The Hospital of Jilin Chemical Industry Company, Jilin 132021, China

Received Date: 17 September 2014
Revised Date: 28 October 2014

Fund Project: This work was financially supported by the National Natural Science Foundation of China (Nos. 51373168, 51233004, 21104076, 51321062 and 51390484), Ministry of Science and Technology of China (International Cooperation and Communication Program 2011DFR51090) and the Program of Scientific Development of Jilin Province (Nos. 20130206066GX, 20130727050YY and 20130521011JH).

Herein, cisplatin-loaded poly(L-glutamic acid)-g-methoxy poly(ethylene glycol) nanoparticles were evaluated as a potential chemotherapeutic agent against osteosarcoma by using alone or with an iRGD (internalizing RGD, CRGDKDPDC). The release rate of platinum from the cisplatin-loaded nanoparticles CDDP/PLG160-g-mPEG2K (CDDP-NPs) accelerated with the increase of the acidity of the environment. In vitro test demonstrated that CDDP-NPs could inhibit the proliferation of MNNG/Hos osteosarcoma cells with IC50 (72 h) of 12.2 gmL-1. In vivo test for MNNG/Hos osteosarcoma tumor bearing mice exhibited that CDDP-NPs had comparable or slightly higher efficacy but significantly lower side effects in comparison with free CDDP. The coadministration of iRGD could further enhance the anticancer efficacy of CDDP-NPs against MNNG/Hos osteosarcoma without bringing obvious side effects. Therefore, CDDP-NPs using alone or with iRGD have great potential for the treatment of osteosarcoma.
- Nanoparticles,
- Biodegradable polymers,
- Cancer chemotherapy,
- Polymeric drug carrier
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