Citation: Zhi-ming Song, Bo Shi, Jian-xun Ding, Xiu-li Zhuang, Xiao-nan Zhang, Chang-feng Fu, Xue-si Chen. Prevention of Postoperative Tendon Adhesion by Biodegradable Electrospun Membrane of Poly(lactide-co-glycolide)[J]. Chinese Journal of Polymer Science, ;2015, 33(4): 587-596. doi: 10.1007/s10118-015-1611-5 shu

Prevention of Postoperative Tendon Adhesion by Biodegradable Electrospun Membrane of Poly(lactide-co-glycolide)

Zhi-ming Song ¹ ,
Bo Shi ^2,3,4 ,
Jian-xun Ding ^2,5,4 ,
Xiu-li Zhuang ^2,5,4 ,
Xiao-nan Zhang ¹ ,
Chang-feng Fu ⁶ ,
Xue-si Chen ^2,5,4

1.
Department of Sports Medicine, First Hospital of Jilin University, Changchun 130021, China
2.
1. Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
3.
2. Department of Spine Surgery, First Hospital of Jilin University, Changchun 130021, China
4.
5.
2. Changchun SinoBiomaterials Co., Ltd., Changchun 130103, China
6.
Department of Spine Surgery, First Hospital of Jilin University, Changchun 130021, China

Received Date: 1 November 2014
Revised Date: 25 July 2014

Fund Project: This work was financially supported by the National Natural Science Foundation of China (Nos. 51303174, 51321062, 51233004, 51390484, 51273196, and 51203153) and the Scientific Development Program of Jilin Province (No. 20140520050JH).

An electrospun poly(lactide-co-glycolide) (PLGA) membrane was prepared and used to perform the anti-adhesion of Achilles tendon. Throughout the experiments, the membrane showed an appropriate degradation rate, and the pH values of degradation media were maintained at around 7.4. Simultaneously, the excellent biocompatibility of the membrane in vitro and in vivo was confirmed by live/dead and histopathological analyses. Meanwhile, the membrane can reduce tendon adhesion significantly and promote functional recovery effectively. The encouraging results were further demonstrated by hematoxylin and eosin (HE), and Masson's trichrome stainings, and type I collagen immunohistochemical analysis. It was concluded that the model treated with the electrospun PLGA membrane was significantly better with respect to the adhesion prevention and tissue repair than that without treatment. Considering the results of degradation and adhesion prevention efficacy, the electrospun PLGA membrane would be a great candidate for the prevention of postoperative tendon adhesion.
- Anti-adhesion,
- Achilles tendon repair,
- Biodegradability,
- Electrospun membrane,
- Poly(lactide-co-glycolide)
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