Citation: Yan-bo Zhang, Jian-xun Ding, Wei-guo Xu, Jie Wu, Fei Chang, Xiu-li Zhuang, Xue-si Chen, Jin-cheng Wang. Biodegradable Thermogel as Culture Matrix of Bone Marrow Mesenchymal Stem Cells for Potential Cartilage Tissue Engineering[J]. Chinese Journal of Polymer Science, ;2014, 32(12): 1590-1601. doi: 10.1007/s10118-014-1551-5 shu

Biodegradable Thermogel as Culture Matrix of Bone Marrow Mesenchymal Stem Cells for Potential Cartilage Tissue Engineering

Yan-bo Zhang ^1,2,3 ,
Jian-xun Ding ^4,5,3 ,
Wei-guo Xu ⁶ ,
Jie Wu ⁶ ,
Fei Chang ⁷ ,
Xiu-li Zhuang ^4,5,3 ,
Xue-si Chen ^4,5,3 ,
Jin-cheng Wang ⁷

1.
1. Department of Orthopedics, the Second Hospital of Jilin University, Changchun 130041, China
2.
2. Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
3.
4.
1. Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
5.
2. Changchun SinoBiomaterials Co., Ltd., Changchun 130103, China
6.
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
7.
Department of Orthopedics, the Second Hospital of Jilin University, Changchun 130041, China

Received Date: 5 March 2014
Revised Date: 16 April 2014

Fund Project: This work was financially supported by the National Natural Science Foundation of China (Nos. 81171681, 51233004, 51273196, 51203153 and 51303174), and the Scientific Development Program of Jilin Province (No. 20140520050JH).

Poly(lactide-co-glycolide)-poly(ethylene glycol)-poly(lactide-co-glycolide) (PLGA-PEG-PLGA) triblock copolymer was synthesized through the ring-opening polymerization of LA and GA with PEG as macroinitiator and stannous octoate as catalyst. The amphiphilic copolymer self-assembled into micelles in aqueous solutions, and formed hydrogels as the increase of temperature at relatively high concentrations ( 15 wt%). The favorable degradability of the hydrogel was confirmed by in vitro and in vivo degradation experiments. The good cellular and tissular compatibilities of the thermogel were demonstrated. The excellent adhesion and proliferation of bone marrow mesenchymal stem cells endowed PLGA-PEG-PLGA thermogelling hydrogel with fascinating prospect for cartilage tissue engineering.
- Bone marrow mesenchymal stem cell,
- Cartilage defect repair,
- Scaffold,
- Thermogel
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