Citation: Qiao Song, Zhi Luo, Xinming Tong, Yi Du, Yanbin Huang. Glutathione as the End Capper for Cyclodextrin/PEG Polyrotaxanes[J]. Chinese Journal of Polymer Science, ;2014, 32(8): 1003-1009. doi: 10.1007/s10118-014-1477-y shu

Glutathione as the End Capper for Cyclodextrin/PEG Polyrotaxanes

Qiao Song ¹ ,
Zhi Luo ¹ ,
Xinming Tong ¹ ,
Yi Du ¹ ,
Yanbin Huang ¹

1.
Department of Chemical Engineering, Tsinghua University, Beijing 100084, China

Received Date: 13 November 2013
Revised Date: 11 January 2014

Fund Project: This work was financially supported by the National Natural Science Foundation of China (No. 21004038)

A facile one-pot synthesis of a-cyclodextrin-based polyrotaxane (PR) in aqueous solution is reported, where the peptide glutathione was used as the end-capping agent and the thiol-ene Michael addition was used as the end-capping reaction. Both polyrotaxanes with low threading ratio and high threading ratio were successfully obtained. In contrast to the conventionally used multiple-step synthesis methods and hydrophobic end cappers, this one-pot aqueous synthesis as well as the biocompatibility of the end-capping agent could result in a much more biocompatible PR to be used as biomaterials.
- Polyrotaxane,
- Cyclodextrin,
- Polyethylene glycol,
- Glutathione,
- Biocompatibility
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