Citation: Xi-qi Zhang, Xiao-yong Zhang, Bin Yang, Yen Wei. Facile Fabrication of Aggregation-induced Emission Based Red Fluorescent Organic Nanoparticles for Cell Imaging[J]. Chinese Journal of Polymer Science, ;2014, 32(7): 871-879. doi: 10.1007/s10118-014-1461-6 shu

Facile Fabrication of Aggregation-induced Emission Based Red Fluorescent Organic Nanoparticles for Cell Imaging

Received Date: 9 October 2013
Revised Date: 19 November 2013

Fund Project: This work was financially supported by the National Natural Science Foundation of China (Nos. 21134004, 21201108 and 51363016), and the National 973 Project (No. 2011CB935700), China Postdoctoral Science Foundation (Nos. 2012M520243, 2013T60100).

A cyano-substituted diarylethlene derivative aggregation-induced emission (AIE) dye with two amino end-groups and 4,4'-(hexafluoroisopropylidene)diphthalic anhydride were facilely incorporated into red fluorescent organic nanoparticles (FONs) via room temperature anhydride ring-opening polymerization under an air atmosphere. These obtained RO-HFDA FONs were characterized by a series of techniques including gel permeation chromatography, Fourier transform infrared spectroscopy, size distribution and zeta potential measurements, UV-Vis absorption spectrum, fluorescent spectroscopy and transmission electron microscopy. Biocompatibility evaluation and cell uptake behavior of RO-HFDA FONs were further investigated to explore their potential biomedical application. We demonstrated that such FONs showed high water dispersibility, stable uniform spherical morphology (150-200 nm), broad excitation band (350-605 nm), intense red fluorescence (627 nm) and excellent biocompatibility, making them promising for cell imaging applications.
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沈阳化工大学材料科学与工程学院沈阳 110142