Citation: Zhi-xiang Cui, Hai-bin Zhao, Yi-yan Peng, Yottha Srithep, Lih-Sheng Turng, Chang-yu Shen. Fabrication of Highly Porous Interconnected Three-dimensional Scaffolds with Micro-channels[J]. Chinese Journal of Polymer Science, ;2014, 32(7): 864-870. doi: 10.1007/s10118-014-1447-4 shu

Fabrication of Highly Porous Interconnected Three-dimensional Scaffolds with Micro-channels

1.
Fujian University of Technology, Fuzhou 350108, China
2.
Shandong University, Jinan 250100, China
3.
University of Wisconsin-Madison, Madison, WI, 53705, USA
4.
Zhengzhou University, Zhengzhou 450002, China

Received Date: 30 September 2013
Revised Date: 14 November 2013

Fund Project: This work was financially supported by the China Scholarship Council and the Wisconsin Institute for Discovery (WID), that enabled the authors to perform this research at the University of Wisconsin-Madison, the National Natural Science Foundation of China (No. 51303027) and the Scientific Research Staring Foundation, Fujian University of Technology, China (No. GY-Z13028).

A novel highly porous 3-D poly(-caprolactone) (PCL) scaffold with micro-channels was fabricated by injection molding and diluent acetic acids leaching technologies. In this study, the chitosan fiber was employed to form the micro-channel in PCL matrix. The morphology, porosity and mechanical properties of the scaffolds were studied and calculated. It was found that the larger the content of chitosan fiber is, the higher the porosity would be, due to the volumetric expansion of chitosan fiber in PCL matrix during it being leached. In addition, the less the content of chitosan fiber is, the higher the compressive modulus would be.
- Injection molding,
- Micro-channel,
- Chitosan fiber,
- Poly(-caprolactone) scaffold
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