Citation: Lu-zhong Zhang, Ya-jun Zhang, Wei Wu, Xi-qun Jiang. DOXORUBICIN-LOADED BORON-RICH POLYMER NANOPARTICLES FOR ORTHOTOPICALLY IMPLANTED LIVER TUMOR TREATMENT[J]. Chinese Journal of Polymer Science, ;2013, 31(5): 778-786. doi: 10.1007/s10118-013-1267-y shu

DOXORUBICIN-LOADED BORON-RICH POLYMER NANOPARTICLES FOR ORTHOTOPICALLY IMPLANTED LIVER TUMOR TREATMENT

Received Date: 19 December 2012
Revised Date: 10 January 2013

Fund Project: This work was financially supported by the National Natural Science Foundation of China (Nos. 51033002 and 51273090).

The in vivo behaviors of doxorubicin (DOX)-loaded dextran-poly(3-acrylamidophenylboronic acid) (Dextran-PAPBA) nanoparticles (NPs) were studied. The DOX-loaded NPs had a narrowly distributed diameter of ca. 74 nm and mainly accumulated in liver of tumor-bearing mice after intravenous injection as demonstrated by in vivo real-time near infrared fluorescent imaging. The DOX contents in various tissues were quantified and consisted well with the results of fluorescent imaging. The biodistribution pattern of DOX-loaded NPs encourages us to investigate their liver tumor treatment by using an orthotopically implanted liver tumor model, revealing that the DOX-loaded NPs formulation had better antitumor effect than free DOX.
- Dextran-PAPBA nanoparticles,
- DOX,
- Drug delivery,
- Antitumor
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