Citation: Ping Ren, Yi-bo Wu, Wen-li Guo, Shu-xin Li, Ying Chen. ABA TRIBLOCK COPOLYMERS WITH PENDANT HYDROXYL GROUPS PREPARED BY CONTROLLED CATIONIC POLYMERIZATION AND THEIR USE AS DELIVERY CARRIER FOR PACLITAXEL[J]. Chinese Journal of Polymer Science, ;2013, 31(2): 285-293. doi: 10.1007/s10118-013-1216-9 shu

ABA TRIBLOCK COPOLYMERS WITH PENDANT HYDROXYL GROUPS PREPARED BY CONTROLLED CATIONIC POLYMERIZATION AND THEIR USE AS DELIVERY CARRIER FOR PACLITAXEL

Received Date: 20 March 2012
Revised Date: 2 July 2012

Fund Project: The work was financially supported by the Program for Excellent Talents in Beijing (No. 2010D005005000005) and Beijing Municipal Education Commission research project (KM 201210017007).

To improve the hydrophilicity of poly(styrene-b-isobutylene-b-styrene) (SIBS), this study focuses on the synthesis of novel functional ABA triblock copolymer thermoplastic elastomers (TPEs) with polyisobutylene (PIB) as rubbery segments. The precursor poly{(styrene-co-4-[2-(tert--butyldimethylsiloxy) ethyl]styrene)-b-isobutylene-b-(styrene-co-4-[2-(tert-butyldimethylsiloxy)ethyl]styrene)}(P(St-co-TBDMES)-PIB-P(St-co-TBDMES)) triblock copolymer was first synthesized by living sequential cationic copolymerization of isobutylene (IB) with styrene (St) and 4-[2-(tert--butyldimethylsiloxy)ethyl]styrene (TBDMES) using 1,4-di(2-chloro-2-propyl)benzene (DiCumCl)/titanium tetrachloride (TiCl4)/2,6-di-tert--butylpyridine (DtBP) as the initiating system. Then, P(St-co-TBDMES)-PIB-P(St-co-TBDMES) was hydrolyzed in the presence of tetra-butylammonium fluoride to yield poly{[styrene-co-4-(2-hydroxyethyl)styrene]-b-isobutylene-b-[styrene-co-4-(2-hydroxyethyl)styrene]} (P(St-co-HOES)-PIB-P(St-co-HOES)) with pendant hydroxyl groups. P(St-co-HOES)-PIB-P(St-co-HOES) used as the paclitaxel carrier was also investigated in this study. Comparing with SIBS, P(St-co-HOES)-PIB-P(St-co-HOES) has exhibited better compatibility with paclitaxel and higher release rate.
- Living cationic polymerization
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