Citation: Wei-fang Tong, Xiao-li Liu, Fei Pan, Zhao-qiang Wu, Wen-wen Jiang. PROTEIN ADSORPTION AND CELL ADHESION ON RGD-FUNCTIONALIZED SILICON SUBSTRATE SURFACES[J]. Chinese Journal of Polymer Science, ;2013, 31(3): 495-502. doi: 10.1007/s10118-013-1210-2 shu

PROTEIN ADSORPTION AND CELL ADHESION ON RGD-FUNCTIONALIZED SILICON SUBSTRATE SURFACES

Corresponding author: Zhao-qiang Wu,
Received Date: 6 June 2012
Revised Date: 1 July 2012

Fund Project: The work was financially supported by the National Natural Science Foundation of China (Nos. 20974122, 21174098) and the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).

A method was developed to modify silicon surfaces with good protein resistance and specific cell attachment. A silicon surface was initially deposited using a block copolymer of N-vinylpyrrolidone (NVP) and 2-hydroxyethyl methacrylate (HEMA) (PVP-b-PHEMA) film through surface-initiated atom transfer radical polymerization and then further immobilized using a short arginine-glycine-aspartate (RGD) peptide. Our results demonstrate that the RGD-modified surfaces (Si-RGD) can suppress non-specific adsorption of proteins and induce the adhesion of L929 cells. The Si-RGD surface exhibited higher cell proliferation rates than the unmodified silicon surface. This research established a simple method for the fabrication of dual-functional silicon surface that combines antifouling and cell attachment promotion.
- Cell adhesion
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