Citation: Li-li Xie, Wei-jun Tong, Jian-quan Xu, Chang-you Gao. MULTILAYERS AND POLY(ALLYLAMINE HYDROCHLORIDE)-graft-POLY(ETHYLENE GLYCOL) MODIFIED BOVINE SERUM ALBUMIN NANOPARTICLES: IMPROVED STABILITY AND pH-RESPONSIVE DRUG DELIVERY[J]. Chinese Journal of Polymer Science, ;2012, 30(5): 719-726. doi: 10.1007/s10118-012-1156-9 shu

MULTILAYERS AND POLY(ALLYLAMINE HYDROCHLORIDE)-graft-POLY(ETHYLENE GLYCOL) MODIFIED BOVINE SERUM ALBUMIN NANOPARTICLES: IMPROVED STABILITY AND pH-RESPONSIVE DRUG DELIVERY

Received Date: 7 December 2011
Revised Date: 1 February 2012

Fund Project: This work was financially supported by the Zhejiang Provincial Natural Science Foundation of China (Nos. Z4090177 and Y4110064), the Ministry of Science and Technology of China for the Indo-China Cooperation (No. 2010DFA51510) and the National Natural Science Foundation of China (Nos. 51120135001 and 21174130).

To improve the colloidal stability of bovine serum albumin (BSA) nanoparticles (NPs) in diverse mediums, poly(allylamine hydrochloride) (PAH)/sodium poly(4-styrene sulfonate) (PSS) multilayers and poly(allylamine hydrochloride)-graft-poly(ethylene glycol) (PAH-g-PEG) coating were coated on the surface of BSA NPs. Stabilities of the BSA NPs in diverse mediums with different surfaces were detected by dynamic light scattering (DLS). Multilayers and PAH-g-PEG coated BSA NPs can be well dispersed in various mediums with a narrow polydispersity index (PDI). The BSA NPs with the highest surface density of PEG show the best stability. The multilayers and PAH-g-PEG coating do not deter the pH-dependent loading and release property of BSA NPs. At pH 9, the encapsulation efficiency of doxorubicin reaches almost 99%, and the release rate at pH 5.5 is significantly higher than that at pH 7.4.
- BSA nanoparticle
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