Citation: Xiao-li Liu, Zhao-qiang Wu, Dan Li, Hong Chen. POLY(N-VINYLPYRROLIDONE)-MODIFIED SURFACES REPEL PLASMA PROTEIN ADSORPTION[J]. Chinese Journal of Polymer Science, ;2012, 30(2): 235-241. doi: 10.1007/s10118-012-1118-2 shu

POLY(N-VINYLPYRROLIDONE)-MODIFIED SURFACES REPEL PLASMA PROTEIN ADSORPTION

Received Date: 25 March 2011
Revised Date: 19 May 2011

Fund Project: This work is financially supported by the National Natural Science Foundation of China (Nos. 20974086, 20974122 and 20920102035), the Ministry of Education of China (209151), the Scientific Research Foundation for the Returned Overseas Chinese Scholars and State Education Ministry.

The present work aimed to study the interaction between plasma proteins and PVP-modified surfaces under more complex protein conditions. In the competitive adsorption of fibrinogen (Fg) and human serum albumin (HSA), the modified surfaces showed preferential adsorption of HSA. In 100% plasma, the amount of Fg adsorbed onto PVP-modified surfaces was as low as 10 ng/cm2, suggesting the excellent protein resistance properties of the modified surfaces. In addition, immunoblots of proteins eluted from the modified surfaces after plasma contact confirmed that PVP-modified surfaces can repel most plasma proteins, especially proteins that play important roles in the process of blood coagulation.
- Poly(N-vinylpyrrolidone)
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