Citation: Kai Zhang a, Man Zhao a, Lei Cai b, Zheng-ke Wang b, Yong-fu Sun b, Qiao-ling Hu b. PREPARATION OF CHITOSAN/HYDROXYAPATITE GUIDED MEMBRANE USED FOR PERIODONTAL TISSUE REGENERATION[J]. Chinese Journal of Polymer Science, ;2010, 28(4): 555-561. doi: 10.1007/s10118-010-9087-9 shu

PREPARATION OF CHITOSAN/HYDROXYAPATITE GUIDED MEMBRANE USED FOR PERIODONTAL TISSUE REGENERATION

Received Date: 8 June 2009
Revised Date: 20 August 2009

In an effort to develop biomaterials to meet guided tissue regeneration (GTR) standards for periodontal tissue recovery, a homogeneous and transparent chitosan (CS)/hydroxyapatite (HA) membrane with potential applications as GTR barrier in periodontal therapy has been prepared via in situ compositing. The membrane has been designed to have a smooth-rough asymmetric structure that meets the demand for GTR. Component and morphology of the membrane are characterized by XRD and SEM. It can be indicated that HA was in situ synthesized uniformly in the CS membrane. Mechanical experiments of the membranes with various HA contents show that their tensile strengths are adequate for periodontal therapy. Biological properties of the membrane have been performed by cell toxicity assays, hemolysis tests and animal experiments. Results indicate that the membrane has good biocompatibility and inductive effect for cell growth. Therefore this membrane can be potentially applied as GTR barrier membrane for periodontal tissue regeneration.
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