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2011 Volume 22 Issue 1
2011, 22(1): 1-4
doi: 10.1016/j.cclet.2010.07.033
Abstract:
This paper described a practical five-step synthetic approach for 2-amino-5-methoxylpropiophenone in 45% overall yield, using 3-chloropropiophenone as the starting material. The advantages of this procedure include short reaction steps, simple operation and good yield.
This paper described a practical five-step synthetic approach for 2-amino-5-methoxylpropiophenone in 45% overall yield, using 3-chloropropiophenone as the starting material. The advantages of this procedure include short reaction steps, simple operation and good yield.
2011, 22(1): 5-8
doi: 10.1016/j.cclet.2010.07.012
Abstract:
Synthetic studies on the construction of 7-O-methylquercetin from quereetin in 36% yield in four steps is reported, this strategy relies on one hand on the selective protection of the catechol group with dichlorodiphenylmethane using dephenyl ether as a solvent, on the other hand, on the selective protection of the 3-hydroxyl group with benzyl bromide, these two different protecting groups can be removed under the same hydrogenation.
Synthetic studies on the construction of 7-O-methylquercetin from quereetin in 36% yield in four steps is reported, this strategy relies on one hand on the selective protection of the catechol group with dichlorodiphenylmethane using dephenyl ether as a solvent, on the other hand, on the selective protection of the 3-hydroxyl group with benzyl bromide, these two different protecting groups can be removed under the same hydrogenation.
2011, 22(1): 9-12
doi: 10.1016/j.cclet.2010.09.003
Abstract:
An efficient, convenient and green method has been introduced for the preparation of 14-aryl(alkyl)-14H-dibenzo[a, j]xanthene and 1, 8-dioxooctahydroxanthene derivatives by the reaction of aldehydes with 2-naphthol and 5, 5-dimethyl-1, 3-cyclohexanedione, respectively, in the presence of ZrO(OTf)2 as a reusable catalyst under solvent-free conditions. In addition, very short reaction times, excellent yields, straightforward procedure, and relatively non-toxicity of the catalyst axe other noteworthy advantages of the present method.
An efficient, convenient and green method has been introduced for the preparation of 14-aryl(alkyl)-14H-dibenzo[a, j]xanthene and 1, 8-dioxooctahydroxanthene derivatives by the reaction of aldehydes with 2-naphthol and 5, 5-dimethyl-1, 3-cyclohexanedione, respectively, in the presence of ZrO(OTf)2 as a reusable catalyst under solvent-free conditions. In addition, very short reaction times, excellent yields, straightforward procedure, and relatively non-toxicity of the catalyst axe other noteworthy advantages of the present method.
2011, 22(1): 13-17
doi: 10.1016/j.cclet.2010.06.002
Abstract:
Mild and efficient method for bromination of electron-rich aromatic compounds is described using polyvinylpolypyrrolidonebromine complex (PVPP-Br2). The reaction proceeded smoothly with phenols and N, N-alkylated amines to afford the corresponding monobrominated product in good yields at ambient temperature.
Mild and efficient method for bromination of electron-rich aromatic compounds is described using polyvinylpolypyrrolidonebromine complex (PVPP-Br2). The reaction proceeded smoothly with phenols and N, N-alkylated amines to afford the corresponding monobrominated product in good yields at ambient temperature.
2011, 22(1): 18-20
doi: 10.1016/j.cclet.2010.07.011
Abstract:
In order to find novel leading structures of pesticide, a series of N-(pyrimidin-5-yl) N'-phenyinreas (4a-4h) were designed and synthesized from 4-chloro-2-diethylamino-6-methyl-5-nitropyrimidine 1 via substitution, reduction and acylation procedures. Preliminary bioassay showed that all the target compounds processing good anti-TMV (tobacco mosaic virus) activity. Two compounds (4d and 4e) displayed higher activity superior to virazole at a concentration of 5.0×10-4 g/mL.
In order to find novel leading structures of pesticide, a series of N-(pyrimidin-5-yl) N'-phenyinreas (4a-4h) were designed and synthesized from 4-chloro-2-diethylamino-6-methyl-5-nitropyrimidine 1 via substitution, reduction and acylation procedures. Preliminary bioassay showed that all the target compounds processing good anti-TMV (tobacco mosaic virus) activity. Two compounds (4d and 4e) displayed higher activity superior to virazole at a concentration of 5.0×10-4 g/mL.
2011, 22(1): 21-24
doi: 10.1016/j.cclet.2010.09.004
Abstract:
The use of in situ generated N-thiocyanatosuccinimide with NH4SCN offers an efficient reagent system for the conversion of epoxides into their corresponding thiocyanohydrines in good to high yields. The major advantages of this method are as follows:use of cheap reagent, high regioselectivity, simple availability of reagent, ease of workup of the reaction.
The use of in situ generated N-thiocyanatosuccinimide with NH4SCN offers an efficient reagent system for the conversion of epoxides into their corresponding thiocyanohydrines in good to high yields. The major advantages of this method are as follows:use of cheap reagent, high regioselectivity, simple availability of reagent, ease of workup of the reaction.
2011, 22(1): 25-28
doi: 10.1016/j.cclet.2010.07.009
Abstract:
Systematic structure modification of the side train of the lead compound saprothoquinone provides a series of salvicine analogues, fifteen of them were first reported. Some compounds were demonstrated potent cytotoxicity against tumor cells with the 50% inhibition concentration in the micromolar range. Furthermore some compounds showed potent topoisomerase Ⅱ inhibitory effects. The preliminary structure-activity relationship of saprorthoquinone analogues was discussed according to their cytotoxicity against three tumor cells.
Systematic structure modification of the side train of the lead compound saprothoquinone provides a series of salvicine analogues, fifteen of them were first reported. Some compounds were demonstrated potent cytotoxicity against tumor cells with the 50% inhibition concentration in the micromolar range. Furthermore some compounds showed potent topoisomerase Ⅱ inhibitory effects. The preliminary structure-activity relationship of saprorthoquinone analogues was discussed according to their cytotoxicity against three tumor cells.
2011, 22(1): 29-32
doi: 10.1016/j.cclet.2010.09.006
Abstract:
A series of novel Michael addition products of fluorene to chalcone were obtained in the presence of sodium hydroxide under solvent-free condition. The advantages of this procedure were mild reaction conditions, simple protocol, and high yields. The structures of the products were characterized by IR, 1H NMR, MS and X-ray diffraction. The crystal of the new compound 3 h is Triclinic, space group P-1 with a=0.97352(6) nm, b=1.08918(7) nm, c=2.58418(16) nm, α=80.1400(10)°, β=79.5490(10)°, γ=64.2440(10)°, V=2.4137(3) nm3, Z=4, Dc=1.220 g/cm3, μ=0.286 mm-1, F(000)=920, R=0.0656 and wR=0.1554 for 5664 observed reflection with I>2σ(I).
A series of novel Michael addition products of fluorene to chalcone were obtained in the presence of sodium hydroxide under solvent-free condition. The advantages of this procedure were mild reaction conditions, simple protocol, and high yields. The structures of the products were characterized by IR, 1H NMR, MS and X-ray diffraction. The crystal of the new compound 3 h is Triclinic, space group P-1 with a=0.97352(6) nm, b=1.08918(7) nm, c=2.58418(16) nm, α=80.1400(10)°, β=79.5490(10)°, γ=64.2440(10)°, V=2.4137(3) nm3, Z=4, Dc=1.220 g/cm3, μ=0.286 mm-1, F(000)=920, R=0.0656 and wR=0.1554 for 5664 observed reflection with I>2σ(I).
2011, 22(1): 33-36
doi: 10.1016/j.cclet.2010.06.041
Abstract:
V(HSO4)3 has been found to be an efficient reagent for the promotion of the oxidation of alcohols and trimethylsilyl, tetrahydropyranyl and methoxymethyl ethers to their corresponding carbonyl compounds with Cu(NO3)2·3H2O in the absence of solvent.
V(HSO4)3 has been found to be an efficient reagent for the promotion of the oxidation of alcohols and trimethylsilyl, tetrahydropyranyl and methoxymethyl ethers to their corresponding carbonyl compounds with Cu(NO3)2·3H2O in the absence of solvent.
2011, 22(1): 37-40
doi: 10.1016/j.cclet.2010.07.019
Abstract:
An easy, safe, solvent free and effective method for the synthesis of pyrazole-substituted chalcones has been achieved by grinding pyrazole aldehydes and acetophenones in the presence of activated barium hydroxide(C-200) in high yield within short span of time.All reactions were carried out just by grinding the two reactants in the presence of activated barium hydroxide(C-200).Results are also compared with sodium hydroxide and potassium hydroxide.
An easy, safe, solvent free and effective method for the synthesis of pyrazole-substituted chalcones has been achieved by grinding pyrazole aldehydes and acetophenones in the presence of activated barium hydroxide(C-200) in high yield within short span of time.All reactions were carried out just by grinding the two reactants in the presence of activated barium hydroxide(C-200).Results are also compared with sodium hydroxide and potassium hydroxide.
2011, 22(1): 41-44
doi: 10.1016/j.cclet.2010.09.010
Abstract:
A novel and facile method of introducing 4-hydroxyl group into the aromatic ring of azabenzanthrone compounds was carded out by reacting azabenzanthrone compounds with hydrazine hydrate or hydroxylamine hydrochloride and sodium hydroxide in diethylene glycol(DEG) solvent.The mechanism of reaction may involve an amino intermediate and follow a hydroxyl substitution process.
A novel and facile method of introducing 4-hydroxyl group into the aromatic ring of azabenzanthrone compounds was carded out by reacting azabenzanthrone compounds with hydrazine hydrate or hydroxylamine hydrochloride and sodium hydroxide in diethylene glycol(DEG) solvent.The mechanism of reaction may involve an amino intermediate and follow a hydroxyl substitution process.
2011, 22(1): 45-48
doi: 10.1016/j.cclet.2010.07.020
Abstract:
14-Aryl or alkyl-14H-dibenzo[a, j]xanthenes were prepared by condensation of 2-naphthol and aldehydes in the presence of Mg(HSO4)2 as an efficient, cheap, readily available and coo-friendly catalyst.This procedure has the advantages of high yields, easy work-up, short reaction times, and green conditions.
14-Aryl or alkyl-14H-dibenzo[a, j]xanthenes were prepared by condensation of 2-naphthol and aldehydes in the presence of Mg(HSO4)2 as an efficient, cheap, readily available and coo-friendly catalyst.This procedure has the advantages of high yields, easy work-up, short reaction times, and green conditions.
2011, 22(1): 49-52
doi: 10.1016/j.cclet.2010.07.021
Abstract:
An efficient synthesis of 5-oxo-2, 5-dihydro-3-furancarboxylate derivatives via reaction of dialkyl acetylenedicarboxylate with triphenylphosphine(Ph3P) in the presence of activated carbonyl compounds such as ethyl pyruvate, benzil, benzoylcyanide, biacetyle or N-alkylisatins is described.
An efficient synthesis of 5-oxo-2, 5-dihydro-3-furancarboxylate derivatives via reaction of dialkyl acetylenedicarboxylate with triphenylphosphine(Ph3P) in the presence of activated carbonyl compounds such as ethyl pyruvate, benzil, benzoylcyanide, biacetyle or N-alkylisatins is described.
2011, 22(1): 53-56
doi: 10.1016/j.cclet.2010.07.027
Abstract:
A reaction of α-bromo aromatic ketones in water with microwave irradiation gave the corresponding α-hydroxy aromatic ketones in good yields.The use of microwaves was found to significantly improve yields and shorten the reaction time.This reaction afforded a very clean, convenient method for the synthesis of α-hydroxy aromatic ketones.
A reaction of α-bromo aromatic ketones in water with microwave irradiation gave the corresponding α-hydroxy aromatic ketones in good yields.The use of microwaves was found to significantly improve yields and shorten the reaction time.This reaction afforded a very clean, convenient method for the synthesis of α-hydroxy aromatic ketones.
2011, 22(1): 57-60
doi: 10.1016/j.cclet.2010.07.028
Abstract:
Novel graphene nanosheet(GNS) supported Cu-Ni bimetal catalysts were firstly synthesized and used for the direct synthesis of dimethyl carbonate (DMC).The experimental results demonstrated that GNS was an effective and convenient support for the fabrication of Cu-Ni/GNS bimetal catalyst.
Novel graphene nanosheet(GNS) supported Cu-Ni bimetal catalysts were firstly synthesized and used for the direct synthesis of dimethyl carbonate (DMC).The experimental results demonstrated that GNS was an effective and convenient support for the fabrication of Cu-Ni/GNS bimetal catalyst.
2011, 22(1): 61-64
doi: 10.1016/j.cclet.2010.07.022
Abstract:
Different 4-substituted 1, 4-dihydropyridines have been oxidized to pyridine derivatives by n-butyltriphenyl phosphonium peroxodisulfate in acetonitrile solution at reflux condition.Formation of two kinds of products has been observed depending on the type of 4-substiment.
Different 4-substituted 1, 4-dihydropyridines have been oxidized to pyridine derivatives by n-butyltriphenyl phosphonium peroxodisulfate in acetonitrile solution at reflux condition.Formation of two kinds of products has been observed depending on the type of 4-substiment.
2011, 22(1): 65-68
doi: 10.1016/j.cclet.2010.09.012
Abstract:
A new series of imidazole-containing 1, 5-benzodiazepines have been synthesized by the condensation of chalcones with ophenylenediamine using piperidine in polyethylene glycol(PEG-400)as an efficient and green reaction solvent.The advantages of this protocol are environmental friendliness, easy work-up, high yields, mild reaction condition and avoidance of expensive catalyst.Furthermore, newly synthesized compounds were evaluated for their antimicrobial activity.
A new series of imidazole-containing 1, 5-benzodiazepines have been synthesized by the condensation of chalcones with ophenylenediamine using piperidine in polyethylene glycol(PEG-400)as an efficient and green reaction solvent.The advantages of this protocol are environmental friendliness, easy work-up, high yields, mild reaction condition and avoidance of expensive catalyst.Furthermore, newly synthesized compounds were evaluated for their antimicrobial activity.
2011, 22(1): 69-72
doi: 10.1016/j.cclet.2010.09.013
Abstract:
2, 3-Dihydroquinazolin-4(1H)-one derivatives are synthesized via a one-pot, three component reaction of isatoic anhydride and an aromatic aldehyde with ammonium acetate or primary amine catalyzed by silica-bonded N-propylsulfamic acid (SBNPSA) in refluxing ethanol.
2, 3-Dihydroquinazolin-4(1H)-one derivatives are synthesized via a one-pot, three component reaction of isatoic anhydride and an aromatic aldehyde with ammonium acetate or primary amine catalyzed by silica-bonded N-propylsulfamic acid (SBNPSA) in refluxing ethanol.
2011, 22(1): 73-76
doi: 10.1016/j.cclet.2010.07.023
Abstract:
A new series of benzamide derivatives as glucokinase activators (GKAs) were designed and synthesized, and their activation for glucokinase were evaluated by the preliminary glucokinase activity assay.The structure-activity relationship (SAR) is discussed.The result shows that compound 12d and 12h have potent activity reference drug RO-28-1675.
A new series of benzamide derivatives as glucokinase activators (GKAs) were designed and synthesized, and their activation for glucokinase were evaluated by the preliminary glucokinase activity assay.The structure-activity relationship (SAR) is discussed.The result shows that compound 12d and 12h have potent activity reference drug RO-28-1675.
2011, 22(1): 77-80
doi: 10.1016/j.cclet.2010.09.009
Abstract:
Two new steroidal glycosides named eyanoauriculoside A(1)and B(2), have been isolated from the roots of Cynanchum auriculatum Royle ex Wight.The structure of cyanoauriculoside A(1)was determined to be 20-O-acetyl-penupogenin-3-O-β-Dglucopyranosyl-(1→4)-β-D-glucopyranosyl-(1→4)-α-L-cymaropyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-α-L-diginopyranosyl-(1→4)-β-D-cymaropyranoside.Cyanoauriculoside B(2)was characterized as 20-O-acetylpenupogenin-3-O-β-D-glucopyranosyl-(1→4)-α-L-cymaropyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-α-L-diginopyranosyl-(1→4)-β-D-cymaropyranoside.The structures of these compounds were elucidated based on the chemical and spectroscopic evidence.
Two new steroidal glycosides named eyanoauriculoside A(1)and B(2), have been isolated from the roots of Cynanchum auriculatum Royle ex Wight.The structure of cyanoauriculoside A(1)was determined to be 20-O-acetyl-penupogenin-3-O-β-Dglucopyranosyl-(1→4)-β-D-glucopyranosyl-(1→4)-α-L-cymaropyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-α-L-diginopyranosyl-(1→4)-β-D-cymaropyranoside.Cyanoauriculoside B(2)was characterized as 20-O-acetylpenupogenin-3-O-β-D-glucopyranosyl-(1→4)-α-L-cymaropyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-α-L-diginopyranosyl-(1→4)-β-D-cymaropyranoside.The structures of these compounds were elucidated based on the chemical and spectroscopic evidence.
2011, 22(1): 81-84
doi: 10.1016/j.cclet.2010.07.029
Abstract:
A novel bacteriohopanoid elucidated as 3β-hydroxy-35-(cyclohexyl-5'-propan-7'-one)-33-ethyl-34-methyl-hactereohopane (1) has been isolated from the bark of Celtis australis (Ulmaceae) together with three known compounds apigenin, quercetin and its glucoside.The structure of 1 was characterized by means of chemical and spectral methods including advanced 2D NMR studies.
A novel bacteriohopanoid elucidated as 3β-hydroxy-35-(cyclohexyl-5'-propan-7'-one)-33-ethyl-34-methyl-hactereohopane (1) has been isolated from the bark of Celtis australis (Ulmaceae) together with three known compounds apigenin, quercetin and its glucoside.The structure of 1 was characterized by means of chemical and spectral methods including advanced 2D NMR studies.
2011, 22(1): 85-87
doi: 10.1016/j.cclet.2010.09.001
Abstract:
A new aryltetrahydronaphthalene lignan, (+)-cycloolivil formaldehyde condensate(1), was isolated from the whole plants of Epimedium brevicornum (Berberidaceae).Its structure was elucidated on the basis of MS, ID and 2D NMR techniques.
A new aryltetrahydronaphthalene lignan, (+)-cycloolivil formaldehyde condensate(1), was isolated from the whole plants of Epimedium brevicornum (Berberidaceae).Its structure was elucidated on the basis of MS, ID and 2D NMR techniques.
2011, 22(1): 88-92
doi: 10.1016/j.cclet.2010.06.018
Abstract:
A series of competitive metal-ion transport experiments has been performed.Each involved transport from an aqueous source phase across an organic membrane phase into an aqueous receiving phase.The source phase contained equimolar concentration of Co(Ⅱ), Ni(Ⅱ), Zn(Ⅱ), Cd(Ⅱ), Ag(Ⅰ), Cu(Ⅱ)and Mn(Ⅱ) metal cations.The transport experiments of metal cations were carried out by 2, 2'-dithio(bis)benzothiazole (DTB) in chloroform (CHCl3).The source phase being buffered at range pH of 4-6.5 and receiving phase being buffered at pH 3.The obtained results show that the selectivity and the efficiency of Ag(Ⅰ) transport from aqueous solutions are observed in this investigation.The effect of concentration of palmitic acid in the transport efficiency of Ag(Ⅰ) ion was also conformed.
A series of competitive metal-ion transport experiments has been performed.Each involved transport from an aqueous source phase across an organic membrane phase into an aqueous receiving phase.The source phase contained equimolar concentration of Co(Ⅱ), Ni(Ⅱ), Zn(Ⅱ), Cd(Ⅱ), Ag(Ⅰ), Cu(Ⅱ)and Mn(Ⅱ) metal cations.The transport experiments of metal cations were carried out by 2, 2'-dithio(bis)benzothiazole (DTB) in chloroform (CHCl3).The source phase being buffered at range pH of 4-6.5 and receiving phase being buffered at pH 3.The obtained results show that the selectivity and the efficiency of Ag(Ⅰ) transport from aqueous solutions are observed in this investigation.The effect of concentration of palmitic acid in the transport efficiency of Ag(Ⅰ) ion was also conformed.
2011, 22(1): 93-96
doi: 10.1016/j.cclet.2010.09.008
Abstract:
Crystal structure and some dynamic performances of Ti0.25V0.34Dy0.01Cr0.1Ni0.3 hydrogen storage electrode alloy have been investigated by XRD, FESEM-EDS, TEM and EIS measurements.The result shows that the alloy is mainly composed of V-based solid solution phase with body-centered-cubic structure and mono-crystal Ni3Ti phase with hexagonal structure (Space grope:P63/mmc), and it was first observed as TiNi-based secondary phase.The higher charge transfer resistance, higher apparent activation energy and lower hydrogen diffusion coefficient are reasons for the poor electrochemical activity of the dehydriding kinetics of Ti-V-Cr-Ni hydride alloy.
Crystal structure and some dynamic performances of Ti0.25V0.34Dy0.01Cr0.1Ni0.3 hydrogen storage electrode alloy have been investigated by XRD, FESEM-EDS, TEM and EIS measurements.The result shows that the alloy is mainly composed of V-based solid solution phase with body-centered-cubic structure and mono-crystal Ni3Ti phase with hexagonal structure (Space grope:P63/mmc), and it was first observed as TiNi-based secondary phase.The higher charge transfer resistance, higher apparent activation energy and lower hydrogen diffusion coefficient are reasons for the poor electrochemical activity of the dehydriding kinetics of Ti-V-Cr-Ni hydride alloy.
2011, 22(1): 97-100
doi: 10.1016/j.cclet.2010.07.010
Abstract:
A novel temperature controlled ionic liquid dispersive liquid phase microextraction (TCIL-DLPME) coupled with rapid resolution liquid chromatography-electrospray tandem mass spectrometry (RRLC-ESI-MS-MS) has been developed for the enrichment and determination of three hexabromocyclododecane diastereomers (HBCDs) in water samples.Green solvent ionic liquid (IL) was used as extraction solvent instead of toxic organic solvents.This technique also avoided the usage of dispersive solvent.Some important parameters that might affect the extraction efficiency were optimized.Under the optimum conditions, good linear relationship, sensitivity and reproducibility were obtained.All the limits of detection for the three diastereomers were 0.1 ng/mL.The linear range was obtained in the range of 1-100 ng/mL for the total amount of three HBCD diastereomers.It was satisfactory to analyze real environmental water samples with the recoveries ranging from 77.2% to 99.3%.The main advantage of the method is toxic organic solvent-free.
A novel temperature controlled ionic liquid dispersive liquid phase microextraction (TCIL-DLPME) coupled with rapid resolution liquid chromatography-electrospray tandem mass spectrometry (RRLC-ESI-MS-MS) has been developed for the enrichment and determination of three hexabromocyclododecane diastereomers (HBCDs) in water samples.Green solvent ionic liquid (IL) was used as extraction solvent instead of toxic organic solvents.This technique also avoided the usage of dispersive solvent.Some important parameters that might affect the extraction efficiency were optimized.Under the optimum conditions, good linear relationship, sensitivity and reproducibility were obtained.All the limits of detection for the three diastereomers were 0.1 ng/mL.The linear range was obtained in the range of 1-100 ng/mL for the total amount of three HBCD diastereomers.It was satisfactory to analyze real environmental water samples with the recoveries ranging from 77.2% to 99.3%.The main advantage of the method is toxic organic solvent-free.
2011, 22(1): 101-104
doi: 10.1016/j.cclet.2010.09.005
Abstract:
The DNA nuclease-like activity of a water soluble manganese corrole 5, 10, 15-tris(N-methyl-4-pyridyl)-corrolatomanganese(Ⅲ) (MnⅢTMPyC) has been investigated.MnⅢTMPyC may bind strongly to DNA via outside groove binding mode as indicated by absorption spectra, viscosity measurements and CD spectra.MnⅢTMPyC exhibited excellent catalytic activity in the DNA oxidative cleavage in the presence of hydroperoxide.
The DNA nuclease-like activity of a water soluble manganese corrole 5, 10, 15-tris(N-methyl-4-pyridyl)-corrolatomanganese(Ⅲ) (MnⅢTMPyC) has been investigated.MnⅢTMPyC may bind strongly to DNA via outside groove binding mode as indicated by absorption spectra, viscosity measurements and CD spectra.MnⅢTMPyC exhibited excellent catalytic activity in the DNA oxidative cleavage in the presence of hydroperoxide.
2011, 22(1): 105-108
doi: 10.1016/j.cclet.2010.09.007
Abstract:
We reported here the simultaneous influence of surface acidity and pore size of Al-substituted hexagonal mesoporous silicas (Aldoped plugs-containing SBA-15 and Al-doped MCM-41) on polymerization of THF.These materials were directly synthesized by introduced aluminum isopropoxide into reaction mixture including surfactant and siliceous precursor.Al-doped plugs-containing SBA-15 (denotes as PAS) samples not only possess typical two-step desorption isotherms, which implied PAS materials generated plugs in their mesochannel, but also exhibit larger pore size and thicker wall than that of Al-doped MCM-41 (denotes as ACM), which implied PAS would have a great advantage on catalytic reaction involving large molecular (e.g.polymer of TI-IF) in industrial point'of view.To investigate catalytic activity of PAS and ACM with moderate acidic sites the polymerization of THF in the presence of acetic anhydride was carded out.The results showed PAS exhibiting good performance on polymerization of THF.Such result could be related to the large pore size and moderate acidic sites.
We reported here the simultaneous influence of surface acidity and pore size of Al-substituted hexagonal mesoporous silicas (Aldoped plugs-containing SBA-15 and Al-doped MCM-41) on polymerization of THF.These materials were directly synthesized by introduced aluminum isopropoxide into reaction mixture including surfactant and siliceous precursor.Al-doped plugs-containing SBA-15 (denotes as PAS) samples not only possess typical two-step desorption isotherms, which implied PAS materials generated plugs in their mesochannel, but also exhibit larger pore size and thicker wall than that of Al-doped MCM-41 (denotes as ACM), which implied PAS would have a great advantage on catalytic reaction involving large molecular (e.g.polymer of TI-IF) in industrial point'of view.To investigate catalytic activity of PAS and ACM with moderate acidic sites the polymerization of THF in the presence of acetic anhydride was carded out.The results showed PAS exhibiting good performance on polymerization of THF.Such result could be related to the large pore size and moderate acidic sites.
2011, 22(1): 109-113
doi: 10.1016/j.cclet.2010.09.019
Abstract:
A novel Schiff base type polyester containing 2, 2'-diamino-4, 4'-bithiazole (DABT) was prepared by low-temperature interface polycondensation of 1, 4-benzenedicarbonyl dichloride with 4, 4'-(4, 4'-bithiazole-2, 2'-diylbis(imine-2, 1-diyl)diphenol (BDDP), which is derived from a 2, 2'-diamino-4, 4'-bithiazole (DABT) Schiff base reacted with a 4-hydroxybenzaldehyde monomer.The newly generated polyester was evaluated based on characterization of its solubility, FTLR spectroscopy, elemental analysis, X-ray diffraction measurements and thermogravimetric analysis (TGA) studies.
A novel Schiff base type polyester containing 2, 2'-diamino-4, 4'-bithiazole (DABT) was prepared by low-temperature interface polycondensation of 1, 4-benzenedicarbonyl dichloride with 4, 4'-(4, 4'-bithiazole-2, 2'-diylbis(imine-2, 1-diyl)diphenol (BDDP), which is derived from a 2, 2'-diamino-4, 4'-bithiazole (DABT) Schiff base reacted with a 4-hydroxybenzaldehyde monomer.The newly generated polyester was evaluated based on characterization of its solubility, FTLR spectroscopy, elemental analysis, X-ray diffraction measurements and thermogravimetric analysis (TGA) studies.
2011, 22(1): 114-118
doi: 10.1016/j.cclet.2010.09.011
Abstract:
Poly(4-vinylpyridinium wibromide) was prepared from poly(4-vinylpyridin) and used for the selective oxidation of a variety of sulfides to the corresponding sulfoxides.The oxidation reaction was carried out heterogeneously in acetone/water, as green solvent, at room temperature.
Poly(4-vinylpyridinium wibromide) was prepared from poly(4-vinylpyridin) and used for the selective oxidation of a variety of sulfides to the corresponding sulfoxides.The oxidation reaction was carried out heterogeneously in acetone/water, as green solvent, at room temperature.
2011, 22(1): 119-122
doi: 10.1016/j.cclet.2010.09.002
Abstract:
A new series of polyamine-toxic cargo conjugates was synthesized with aryl aldehydes conjugating to hydrazino-containing triamine skeletons.The in vitro cytotoxicity of target compounds was evaluated in several cancer cell lines (e.g., L1210, HeLa and B16) and the cellular entry of these polyamine conjugates via polyamine transporter was investigated on SPD-or DFMO-treated B16 cell line.Of these compounds, 6c show significant cytotoxicity on L1210, HeLa and B 16 cell lines (IC50 value, 3.74 μmol/L, 5.66 μmol/L and 4.04 μmol/L, respectively).The polyamine transporter assay demonstrated the suitability of hydrazino-containing polyamine backbones for application as vectors in drug delivery systems.
A new series of polyamine-toxic cargo conjugates was synthesized with aryl aldehydes conjugating to hydrazino-containing triamine skeletons.The in vitro cytotoxicity of target compounds was evaluated in several cancer cell lines (e.g., L1210, HeLa and B16) and the cellular entry of these polyamine conjugates via polyamine transporter was investigated on SPD-or DFMO-treated B16 cell line.Of these compounds, 6c show significant cytotoxicity on L1210, HeLa and B 16 cell lines (IC50 value, 3.74 μmol/L, 5.66 μmol/L and 4.04 μmol/L, respectively).The polyamine transporter assay demonstrated the suitability of hydrazino-containing polyamine backbones for application as vectors in drug delivery systems.
2011, 22(1): 123-126
doi: 10.1016/j.cclet.2010.06.034
Abstract:
A new method to fabricate metal/conducting polymer composite nanowires is presented by taking silver/polypyrrole composite nanowires as an example.A silver (Ⅰ)-coordinated organogel as template was prepared firstly, and redox-polymerization of pyrrole took place on the gel fiber, giving product of silver/polypyrrole nanowires.The silver/polypyrrole nanowires were characterized by multiple techniques.This strategy could be carried out in one-step procedure at room temperature, and it proves the utility of coordinated organogels in template synthesis of polymer nanostructures.
A new method to fabricate metal/conducting polymer composite nanowires is presented by taking silver/polypyrrole composite nanowires as an example.A silver (Ⅰ)-coordinated organogel as template was prepared firstly, and redox-polymerization of pyrrole took place on the gel fiber, giving product of silver/polypyrrole nanowires.The silver/polypyrrole nanowires were characterized by multiple techniques.This strategy could be carried out in one-step procedure at room temperature, and it proves the utility of coordinated organogels in template synthesis of polymer nanostructures.
