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2001 Volume 12 Issue 6
2001, 12(6): 471-474
Abstract:
During the synthesis of the derivatives of styryl ketonic Mannich bases, a side-product IM,other than the normal Mannich base MA, is obtained. Mannich reaction is further studied and the formation mechanism of product IM is postulated and discussed on the basis of deuterium labelling.
During the synthesis of the derivatives of styryl ketonic Mannich bases, a side-product IM,other than the normal Mannich base MA, is obtained. Mannich reaction is further studied and the formation mechanism of product IM is postulated and discussed on the basis of deuterium labelling.
2001, 12(6): 475-476
Abstract:
Synthesis of a novel series of N-pyrandione substituted amino acids and their esters 3 via a condensation reaction between pyrandione and amino acid or their derivatives in excess ethyl orthoformate without solvent is described. The stereochemistry of 3 has been discussed.
Synthesis of a novel series of N-pyrandione substituted amino acids and their esters 3 via a condensation reaction between pyrandione and amino acid or their derivatives in excess ethyl orthoformate without solvent is described. The stereochemistry of 3 has been discussed.
2001, 12(6): 477-478
Abstract:
Benzotriazol-1-yl methyl selenides and tellurides 4a-h can be simply synthesized by the reaction of 2a-b with 3 in good yields.
Benzotriazol-1-yl methyl selenides and tellurides 4a-h can be simply synthesized by the reaction of 2a-b with 3 in good yields.
2001, 12(6): 479-482
Abstract:
The synthesis, characterization of five ditopic or tritopic crown compounds were reported in this paper together with the preparation of the corresponding hetero-dinuclear and hetero-trinuclear complexes with different metal cations.
The synthesis, characterization of five ditopic or tritopic crown compounds were reported in this paper together with the preparation of the corresponding hetero-dinuclear and hetero-trinuclear complexes with different metal cations.
2001, 12(6): 483-484
Abstract:
Three spin labeled daunomycin derivatives 2-4 were synthesized and their biological activities were tested against mouse leukemia L1210 and human liver cancer BEL-7402 cells in vitro.
Three spin labeled daunomycin derivatives 2-4 were synthesized and their biological activities were tested against mouse leukemia L1210 and human liver cancer BEL-7402 cells in vitro.
2001, 12(6): 485-486
Abstract:
The first enantioselective synthesis approach to two chiral 1,4-benzodioxane neolignans isoamericanol A and isoamericanin A was reported.
The first enantioselective synthesis approach to two chiral 1,4-benzodioxane neolignans isoamericanol A and isoamericanin A was reported.
2001, 12(6): 487-488
Abstract:
The target compound BCH-189 was synthesized with high yield via four steps from benzoyloxy acetylaldehyde and p-dithiane-2,5-diol as starting materials. The synthetic route is preferable to what literature reported.
The target compound BCH-189 was synthesized with high yield via four steps from benzoyloxy acetylaldehyde and p-dithiane-2,5-diol as starting materials. The synthetic route is preferable to what literature reported.
2001, 12(6): 489-490
Abstract:
A series of novel enantiomerically pure diols were synthesized from D-erythorbic acid in three steps, and the absolute configuration of one of them 4a has been confirmed by X-ray analysis.
A series of novel enantiomerically pure diols were synthesized from D-erythorbic acid in three steps, and the absolute configuration of one of them 4a has been confirmed by X-ray analysis.
2001, 12(6): 491-494
Abstract:
The present paper reports the synthesis of two analogs of Schzandrin C α-DDB, β-DDB with the gallic acid as the starting material. The key step is the synthesis of monomer of β-DDB and α-DDB for coupling. α-DDB, β-DDB have different yields in Ullmann coupling reaction under the same condition. The yield of α-DDB is little lower than that of β-DDB. The AM1 calculation demonstrates that ΔH of the Ullmann coupling reaction of α-DDB and β-DDB are different. The former is -175.76966KJ/mol and the later is -203.21246KJ/mol. This is in agreement with the fact that β-DDB has higher yield than α-DDB.
The present paper reports the synthesis of two analogs of Schzandrin C α-DDB, β-DDB with the gallic acid as the starting material. The key step is the synthesis of monomer of β-DDB and α-DDB for coupling. α-DDB, β-DDB have different yields in Ullmann coupling reaction under the same condition. The yield of α-DDB is little lower than that of β-DDB. The AM1 calculation demonstrates that ΔH of the Ullmann coupling reaction of α-DDB and β-DDB are different. The former is -175.76966KJ/mol and the later is -203.21246KJ/mol. This is in agreement with the fact that β-DDB has higher yield than α-DDB.
2001, 12(6): 495-496
Abstract:
Copper (Ⅱ) complex derived from 2, 2'-pyridil ligand has been demonstrated to cleave efficiently DNA at micromolar concentrations at room temperature and pH 7.25.
Copper (Ⅱ) complex derived from 2, 2'-pyridil ligand has been demonstrated to cleave efficiently DNA at micromolar concentrations at room temperature and pH 7.25.
2001, 12(6): 497-498
Abstract:
Antigen 12, containing a phosphonyl peptide hapten with free C-terminal carboxylic group, was synthesized by 11 reaction steps. The design of the hapten was based on the transition state of peptide hydrolysis catalyzed by carboxypeptidase A.
Antigen 12, containing a phosphonyl peptide hapten with free C-terminal carboxylic group, was synthesized by 11 reaction steps. The design of the hapten was based on the transition state of peptide hydrolysis catalyzed by carboxypeptidase A.
2001, 12(6): 499-500
Abstract:
Two 2-aryl imidazo [2,1-a] isoquinolines were synthesized and tested for pregnancy terminating activities. Both of them are new compounds and their structures were confirmed by IR, 1HNMR, MS and elemental analysis. They both showed high activities in NIH mice.
Two 2-aryl imidazo [2,1-a] isoquinolines were synthesized and tested for pregnancy terminating activities. Both of them are new compounds and their structures were confirmed by IR, 1HNMR, MS and elemental analysis. They both showed high activities in NIH mice.
2001, 12(6): 501-502
Abstract:
A E-2-[(3'-indole) cyanomethylene]-3-indolinone was isolated from the root of Isatis indigotica Fort. The structure elucidation and 1H, 13C NMR assignments were achieved by spectroscopic method.
A E-2-[(3'-indole) cyanomethylene]-3-indolinone was isolated from the root of Isatis indigotica Fort. The structure elucidation and 1H, 13C NMR assignments were achieved by spectroscopic method.
2001, 12(6): 503-506
Abstract:
2,3,5,4'-tetrahydroxystilbene-2-O-(2"-O-feruloyl)-β-D-glucopyranoside, 2,3,5,4'-tetra hydroxystilbene-2-O-(2"-O-p-coumaroyl)-β-D-glucopyranoside were isolated from Radix Polygoni multiflori Preparata. Structures were elucidated by chemical and spectral evidences.
2,3,5,4'-tetrahydroxystilbene-2-O-(2"-O-feruloyl)-β-D-glucopyranoside, 2,3,5,4'-tetra hydroxystilbene-2-O-(2"-O-p-coumaroyl)-β-D-glucopyranoside were isolated from Radix Polygoni multiflori Preparata. Structures were elucidated by chemical and spectral evidences.
2001, 12(6): 507-508
Abstract:
A new triterpene 1, 1β, 2α, 3β-trihydroxylup-20 (29)-ene was isolated from Cepha-lomappa sinensis. The structure was elucidated mainly on the basis of 1D and 2D NMR spectral means.
A new triterpene 1, 1β, 2α, 3β-trihydroxylup-20 (29)-ene was isolated from Cepha-lomappa sinensis. The structure was elucidated mainly on the basis of 1D and 2D NMR spectral means.
2001, 12(6): 509-510
Abstract:
A new caffeoylquiniclactone, named neochlorgeniclatone, was isolated from the leaves of Betula platyphylla Suk. The structure was established by spectroscopic data.
A new caffeoylquiniclactone, named neochlorgeniclatone, was isolated from the leaves of Betula platyphylla Suk. The structure was established by spectroscopic data.
2001, 12(6): 511-512
Abstract:
Supramolecular interaction of calix [4]pyrroles with several inorganic anions is reported by addition of calix [4]pyrroles to background electrolyte (BGE) in CZE. The retention time (tR) of all anions increased with increasing concentration of calix [4]pyrroles. The effect on F- is most evident.
Supramolecular interaction of calix [4]pyrroles with several inorganic anions is reported by addition of calix [4]pyrroles to background electrolyte (BGE) in CZE. The retention time (tR) of all anions increased with increasing concentration of calix [4]pyrroles. The effect on F- is most evident.
2001, 12(6): 513-516
Abstract:
Eight metabolites of brodimoprim (BDP) in rat urine were detected by NMR and ESI-MS/MS. They were demethyl-BDP glucuronide, demethyl-BDP sulfurate, demethyl-BDP glucuronide sulfurate, α-hydroxyl-BDP, α-hydroxyl-BDP glucuronide, BDP sulfurate, N-oxide-BDP sulfurate, and α-hydroxyl-N-oxide-BDP sulfurate. All the sulfurates are reported for the first time.
Eight metabolites of brodimoprim (BDP) in rat urine were detected by NMR and ESI-MS/MS. They were demethyl-BDP glucuronide, demethyl-BDP sulfurate, demethyl-BDP glucuronide sulfurate, α-hydroxyl-BDP, α-hydroxyl-BDP glucuronide, BDP sulfurate, N-oxide-BDP sulfurate, and α-hydroxyl-N-oxide-BDP sulfurate. All the sulfurates are reported for the first time.
2001, 12(6): 517-518
Abstract:
A novel diamine monomer 2H-(4-aminophenyl)-4-[4-(4-aminophenoxy) biphenyl]-phthalazinone 1 containing aza hetero cycle was synthesized and utilized for preparation of new high molecular weight aromatic polyamides with various aromatic dicarboxylic acids with the inherent viscosity of 0.50~1.62 g/dL. These polyamides had rather high glass transition temperatures of 327~356℃ and their structure was confirmed by IR, 1H NMR and MS. They are readily soluble in polar solvents such as NMP, DMF etc. and easily cast into tough, flexible films.
A novel diamine monomer 2H-(4-aminophenyl)-4-[4-(4-aminophenoxy) biphenyl]-phthalazinone 1 containing aza hetero cycle was synthesized and utilized for preparation of new high molecular weight aromatic polyamides with various aromatic dicarboxylic acids with the inherent viscosity of 0.50~1.62 g/dL. These polyamides had rather high glass transition temperatures of 327~356℃ and their structure was confirmed by IR, 1H NMR and MS. They are readily soluble in polar solvents such as NMP, DMF etc. and easily cast into tough, flexible films.
2001, 12(6): 519-522
Abstract:
Enantioselective alternating copolymerization of carbon monoxide with propylene was carried out using palladium catalyst modified by 1,4-3,6-dianhydro-2,5-dideoxy-2,5-bis (diphenylphosphino)-L-iditol (DDPPI). The chiral diphosphine was proved to be effective at enantioselective copolymerization. Optical rotation, elemental analysis, 1H, 13C-NMR and IR spectra showed that the copolymer was optically active, isotactic, alternating poly(1,4-ketone) structure.
Enantioselective alternating copolymerization of carbon monoxide with propylene was carried out using palladium catalyst modified by 1,4-3,6-dianhydro-2,5-dideoxy-2,5-bis (diphenylphosphino)-L-iditol (DDPPI). The chiral diphosphine was proved to be effective at enantioselective copolymerization. Optical rotation, elemental analysis, 1H, 13C-NMR and IR spectra showed that the copolymer was optically active, isotactic, alternating poly(1,4-ketone) structure.
2001, 12(6): 523-526
Abstract:
Three new cationic polymerizable surfactants are synthesized by the reaction of alkylmaleic hemiester with glycidyltrimethylammonium chloride. Their structures are confirmed by 1H NMR, IR and elements analysis. The values of CMC and γCMC of these surfactants have been measured. One can obtain nearly monodisperse polystyrene latex by emulsion polymerization using the polymerizable surfactant.
Three new cationic polymerizable surfactants are synthesized by the reaction of alkylmaleic hemiester with glycidyltrimethylammonium chloride. Their structures are confirmed by 1H NMR, IR and elements analysis. The values of CMC and γCMC of these surfactants have been measured. One can obtain nearly monodisperse polystyrene latex by emulsion polymerization using the polymerizable surfactant.
2001, 12(6): 527-528
Abstract:
The catalytic properties of natural mordenite as acidic catalysts were investigated using the ammoniation of methanol.
The catalytic properties of natural mordenite as acidic catalysts were investigated using the ammoniation of methanol.
2001, 12(6): 529-532
Abstract:
Methanol and detergent are chosen to be additives for the catalysts derived from active carbon supported MgO and cobalt phthalocyanine (CoPc) or CoPc/NaY zeolite, and dramatically improved the activity and stability of catalyst in autoxidation of 1-octanethiol.
Methanol and detergent are chosen to be additives for the catalysts derived from active carbon supported MgO and cobalt phthalocyanine (CoPc) or CoPc/NaY zeolite, and dramatically improved the activity and stability of catalyst in autoxidation of 1-octanethiol.
2001, 12(6): 533-536
Abstract:
A novel supported liquid phase film catalyst:Supported PdCl2-(n-C4H9)4N+Cl- molten salts was found to be an effective catalyst with good stability for selective hydrodechlorination of CCl2F2 (CFC-12) to its alternatives CH2F2 and CHClF2. Addition of CoCl2, GaCl3 and CuCl2 to PdCl2-(n-C4H9)4N+Cl- modifies the catalytic performance of supported molten salts.
A novel supported liquid phase film catalyst:Supported PdCl2-(n-C4H9)4N+Cl- molten salts was found to be an effective catalyst with good stability for selective hydrodechlorination of CCl2F2 (CFC-12) to its alternatives CH2F2 and CHClF2. Addition of CoCl2, GaCl3 and CuCl2 to PdCl2-(n-C4H9)4N+Cl- modifies the catalytic performance of supported molten salts.
2001, 12(6): 537-540
Abstract:
Titanium-modified γ-alumina supported CuO catalyst has been prepared and used to methanol synthesis from CO2 hydrogenation. The addition of Ti to the CuO/γ-Al2O3 catalyst made the copper in the cataσlyst exist in much smaller crystallites. The effect of the loading of Ti on the activity and selectivity to methanol from CO2 hydrogenation was investigated. The activity was found to increase with the increasing of surface area of metallic copper, but it is not a linear relationship.
Titanium-modified γ-alumina supported CuO catalyst has been prepared and used to methanol synthesis from CO2 hydrogenation. The addition of Ti to the CuO/γ-Al2O3 catalyst made the copper in the cataσlyst exist in much smaller crystallites. The effect of the loading of Ti on the activity and selectivity to methanol from CO2 hydrogenation was investigated. The activity was found to increase with the increasing of surface area of metallic copper, but it is not a linear relationship.
2001, 12(6): 541-544
Abstract:
The nature of bonding in the title compounds has been studied by using CASSCF and FOCI techniques. The ground states of PtC and PtN are found to be 1Σ+ and 2Π state arising primarily from:…1σ22σ21π41δ43σ2 and …1σ22σ21π41δ43σ22π1 configuration respectively and both of which form triple bond (one σ, two πbonds), but the bond of PtC is much stronger than that of PtN.
The nature of bonding in the title compounds has been studied by using CASSCF and FOCI techniques. The ground states of PtC and PtN are found to be 1Σ+ and 2Π state arising primarily from:…1σ22σ21π41δ43σ2 and …1σ22σ21π41δ43σ22π1 configuration respectively and both of which form triple bond (one σ, two πbonds), but the bond of PtC is much stronger than that of PtN.
2001, 12(6): 545-548
Abstract:
Carbon nanotubes (CNTs) were syntecized by catalytic chemical deposition and using the alkali-reducing prereated hydrogen storage alloy (MINI4.0Co0.6Al0.4)powder as a catalyst I was found that the surface modification of the alloy was effective to provide the catalytic active sites for CNTs growth.The Ni-and Co-clusters on the surface of the treated alloy were dominant for the growth of CNTs. The composite of CNTs with the hydrogen storage alloy has the potential to be used as a new type of hydrogen storage material without further purther purfication
Carbon nanotubes (CNTs) were syntecized by catalytic chemical deposition and using the alkali-reducing prereated hydrogen storage alloy (MINI4.0Co0.6Al0.4)powder as a catalyst I was found that the surface modification of the alloy was effective to provide the catalytic active sites for CNTs growth.The Ni-and Co-clusters on the surface of the treated alloy were dominant for the growth of CNTs. The composite of CNTs with the hydrogen storage alloy has the potential to be used as a new type of hydrogen storage material without further purther purfication
2001, 12(6): 549-550
Abstract:
The Photocatalytic characterization of TiO2 supported on active carbon was investigated for photocatalytic decomposition of dichloroacetic acid. It was found that TiO2/AC exhibited a higher photocatalytic activity than pure TiO2. The reason is that active carbon acting as powerful adsorbent supports makes high concentration environments of organic pollutant molecules around TiO2 particles.
The Photocatalytic characterization of TiO2 supported on active carbon was investigated for photocatalytic decomposition of dichloroacetic acid. It was found that TiO2/AC exhibited a higher photocatalytic activity than pure TiO2. The reason is that active carbon acting as powerful adsorbent supports makes high concentration environments of organic pollutant molecules around TiO2 particles.
2001, 12(6): 551-554
Abstract:
The Au nanoparticles has been prepared by microwave high-pressure procedure with alcohol as the reducing agent. The color of colloidal Au nanoparticles is blue-violet. The maximum absorption spectrum of colloidal Au is at 580 nm, and the resonance scattering peak is at 580 nm. Using this method, the colloidal Au of long-time stability can be prepared simply and quickly.
The Au nanoparticles has been prepared by microwave high-pressure procedure with alcohol as the reducing agent. The color of colloidal Au nanoparticles is blue-violet. The maximum absorption spectrum of colloidal Au is at 580 nm, and the resonance scattering peak is at 580 nm. Using this method, the colloidal Au of long-time stability can be prepared simply and quickly.
2001, 12(6): 555-558
Abstract:
Nanocrystalline cobalt powders have been prepared from aqueous solution by reducing their corresponding metal salts under suitable conditions. The experimental conditions have been studied in detail. X-ray powder diffraction patterns show that the cobalt powder is hexagonal crystallite. The average particle size of the ultrafine cobalt powder is 55 nm.
Nanocrystalline cobalt powders have been prepared from aqueous solution by reducing their corresponding metal salts under suitable conditions. The experimental conditions have been studied in detail. X-ray powder diffraction patterns show that the cobalt powder is hexagonal crystallite. The average particle size of the ultrafine cobalt powder is 55 nm.
2001, 12(6): 559-562
Abstract:
The platinum (Ⅱ) complexes of the [Pt (N4,N7-Ribavirin) (DMSO) Cl],[Pt (N4,N7-De-oxyribavirin) (DMSO) Cl] were obtained by the reactions of cis-[Pt (DMSO)2 Cl2] and K[Pt (DMSO) Cl3] with 1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (Ribavirin) and its deoxy-analogue (deoxyribavirin). The preparation of 1-(2'-deoxy-β-D-ribofuranosyl)-1,2,4-triazole-3-carboxamide was also performed through a four-step procedure, protection of 3', 5'-dihydroxyl group of Ribavirin with 1,3-dichloro-1,1,3,3-tetraisopropyldisiloxane (TPDS-Cl), phenoxythio-carbonylation of the 2'-hydroxyl group of 3', 5'-O-TPDS-Ribavirin with phenoxythiocarbonyl-chloride (PTC-Cl), reduction of 2'-O-phenoxythiocarbonyl ester of 3', 5'-O-TPDS-Ribavirin with tri-n-butyltin hydride and AIBN, deprotection of 3', 5'-O-TPDS-Ribavirin with tetrabutylammon-ium fluoride in THF.
The platinum (Ⅱ) complexes of the [Pt (N4,N7-Ribavirin) (DMSO) Cl],[Pt (N4,N7-De-oxyribavirin) (DMSO) Cl] were obtained by the reactions of cis-[Pt (DMSO)2 Cl2] and K[Pt (DMSO) Cl3] with 1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (Ribavirin) and its deoxy-analogue (deoxyribavirin). The preparation of 1-(2'-deoxy-β-D-ribofuranosyl)-1,2,4-triazole-3-carboxamide was also performed through a four-step procedure, protection of 3', 5'-dihydroxyl group of Ribavirin with 1,3-dichloro-1,1,3,3-tetraisopropyldisiloxane (TPDS-Cl), phenoxythio-carbonylation of the 2'-hydroxyl group of 3', 5'-O-TPDS-Ribavirin with phenoxythiocarbonyl-chloride (PTC-Cl), reduction of 2'-O-phenoxythiocarbonyl ester of 3', 5'-O-TPDS-Ribavirin with tri-n-butyltin hydride and AIBN, deprotection of 3', 5'-O-TPDS-Ribavirin with tetrabutylammon-ium fluoride in THF.
2001, 12(6): 563-564
Abstract:
The Zinc complex of N, N-bis (benzimidazol-2-yl-methyl)amine has been synthesized and its crystal structure determined by X-ray diffraction method. The structure features of the complex are described.
The Zinc complex of N, N-bis (benzimidazol-2-yl-methyl)amine has been synthesized and its crystal structure determined by X-ray diffraction method. The structure features of the complex are described.
