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2001 Volume 12 Issue 5
2001, 12(5): 377-378
Abstract:
The diaryldiselenides reacted with titanocene hydried (Cp2TiH) generted from Cp2TiCl2/i-BuMgBr to give arylselenium complexes of titanocene.They reacted readily with diaryliodoiums salt to give unsymmetical diarylselenides.
The diaryldiselenides reacted with titanocene hydried (Cp2TiH) generted from Cp2TiCl2/i-BuMgBr to give arylselenium complexes of titanocene.They reacted readily with diaryliodoiums salt to give unsymmetical diarylselenides.
2001, 12(5): 379-382
Abstract:
The reduction of elemental selenium by samarium diiodide led to selective formation of selenolate anion species (Se22- and Se2-),these nucleophilic species reacted readly with sodium alkyl thiosulfates to afford dithiodiselenides and dithioselenides in moderate to good yield under mild conditions.
The reduction of elemental selenium by samarium diiodide led to selective formation of selenolate anion species (Se22- and Se2-),these nucleophilic species reacted readly with sodium alkyl thiosulfates to afford dithiodiselenides and dithioselenides in moderate to good yield under mild conditions.
2001, 12(5): 383-386
Abstract:
A rapid and efficient method for the preparation of diaryl thiourea compounds was reported for the first time.Twelve diaryl thiourea compounds that possessing biological activity have been synthesized in excellent yields (91-97%).The reaction proved to be extremely simple and highly efficient (in 1.5-4.5 min).
A rapid and efficient method for the preparation of diaryl thiourea compounds was reported for the first time.Twelve diaryl thiourea compounds that possessing biological activity have been synthesized in excellent yields (91-97%).The reaction proved to be extremely simple and highly efficient (in 1.5-4.5 min).
2001, 12(5): 387-390
Abstract:
Ethynylferrocene and iodoethynylferrocene were prepared in high yield as 88-90% through a one-pot procedure.1,1'-diiodoferrocenylene was in-situ prepared from reaction of CHI3 PPh3,t-BuOK and ferrocenecarboxaldehyde,further reaction with t-BuOK or n-BuLi gave the title compounds.
Ethynylferrocene and iodoethynylferrocene were prepared in high yield as 88-90% through a one-pot procedure.1,1'-diiodoferrocenylene was in-situ prepared from reaction of CHI3 PPh3,t-BuOK and ferrocenecarboxaldehyde,further reaction with t-BuOK or n-BuLi gave the title compounds.
2001, 12(5): 391-394
Abstract:
Coupling reaction of 4-chloro-7-H-pyrrolo [2,3-d]pyrimidine with 2,3,5-tri-O-acetyl-β-D-ribofuranosyl chloride under the basic condition was investigated.An abnormal coupling reaction,in which the heterocyclic base attacked at the carbon of 1,2-O-methylidene moiety instead of anomeric carbon of ribose was observed and the structure of products 5a,5b were identified by NMR and X-Ray diffraction.
Coupling reaction of 4-chloro-7-H-pyrrolo [2,3-d]pyrimidine with 2,3,5-tri-O-acetyl-β-D-ribofuranosyl chloride under the basic condition was investigated.An abnormal coupling reaction,in which the heterocyclic base attacked at the carbon of 1,2-O-methylidene moiety instead of anomeric carbon of ribose was observed and the structure of products 5a,5b were identified by NMR and X-Ray diffraction.
2001, 12(5): 395-396
Abstract:
Readily available 2-methylquinoline derived chiral ligands 1 and 2 have been applied in the enantioselective addition of diethylzinc to aldehydes with up to 91.4% ee being recorded.
Readily available 2-methylquinoline derived chiral ligands 1 and 2 have been applied in the enantioselective addition of diethylzinc to aldehydes with up to 91.4% ee being recorded.
2001, 12(5): 397-398
Abstract:
Stereoselective functionalization at C-2 and C-3 of the gibberellin skeleton was achieved via an intramolecular free radical cyclization approach using a tethered C-19 halomethyl ester as the radical precursor.
Stereoselective functionalization at C-2 and C-3 of the gibberellin skeleton was achieved via an intramolecular free radical cyclization approach using a tethered C-19 halomethyl ester as the radical precursor.
A Novel Palladium-Catalyzed Reaction and Its Application in Preparation of Derivatives of Stilbazols
2001, 12(5): 399-402
Abstract:
A novel palladium-catalyzed coupling reaction for the preparation of derivatives of stilbazoles was presented.A series of stilbazoles were synthesized firstly by this highly efficient method.From this reaction it was found that reaction solvent is one of important factors in this catalytic system.
A novel palladium-catalyzed coupling reaction for the preparation of derivatives of stilbazoles was presented.A series of stilbazoles were synthesized firstly by this highly efficient method.From this reaction it was found that reaction solvent is one of important factors in this catalytic system.
2001, 12(5): 403-406
Abstract:
Michael addition of the chiral α,β-unsaturated ester 2 with furyl lithium proceeded in syn manner with excellent diastereoselectivity.The diastereoselectivity was not affected by the configuration of the double bond in 2.
Michael addition of the chiral α,β-unsaturated ester 2 with furyl lithium proceeded in syn manner with excellent diastereoselectivity.The diastereoselectivity was not affected by the configuration of the double bond in 2.
2001, 12(5): 407-408
Abstract:
The first total synthesis of 5α-hydroxy-isopterocarpolone has been described.
The first total synthesis of 5α-hydroxy-isopterocarpolone has been described.
2001, 12(5): 409-410
Abstract:
Total synthesis of 7-O-geranyl-pseudobaptigenin is described,the key steps are Grignard reaction and cyclization reaction.
Total synthesis of 7-O-geranyl-pseudobaptigenin is described,the key steps are Grignard reaction and cyclization reaction.
2001, 12(5): 411-412
Abstract:
The terpolymer of itaconic acid,acrylamide and 2-acrylamido-2-methyl-1-propane sulfonic acid was synthesized through the free-radical polymerization.The IR spectra confirmed that there was no olefinic band,while the TGA results revealed that the terpolymer was of high thermal stability.
The terpolymer of itaconic acid,acrylamide and 2-acrylamido-2-methyl-1-propane sulfonic acid was synthesized through the free-radical polymerization.The IR spectra confirmed that there was no olefinic band,while the TGA results revealed that the terpolymer was of high thermal stability.
2001, 12(5): 413-416
Abstract:
A series of new chiral molecular tweezers have been designed and synthesized by using deoxycholic acid as spacer and aromatic amines as arms.Instead of using toxic phosgene,the triphosgene was employed in synthesis of the molecular tweezers receptors.These chiral molecular tweezers showed good enantioselectivity for D-amino acid methyl esters.
A series of new chiral molecular tweezers have been designed and synthesized by using deoxycholic acid as spacer and aromatic amines as arms.Instead of using toxic phosgene,the triphosgene was employed in synthesis of the molecular tweezers receptors.These chiral molecular tweezers showed good enantioselectivity for D-amino acid methyl esters.
2001, 12(5): 417-318
Abstract:
A new series of (E)-5-[2-(N-hexylcarbazolyl) vinyl] furan chromophores with various acceptors have been synthesized by the Knoevenagel condensation of (E)-5-[2-(N-hexylcarbazolyl) vinyl]-2-furaldehydes with malononitrile,1,3-diethyl-2-thiobarbituric acid,or 3-phenyl-5-isoxazol one,respectively.They are characterized by 1H-NMR,FT-IR,UV-VIS,MS and elemental analysis,and have shown strong solvatochromism and high thermal stability.
A new series of (E)-5-[2-(N-hexylcarbazolyl) vinyl] furan chromophores with various acceptors have been synthesized by the Knoevenagel condensation of (E)-5-[2-(N-hexylcarbazolyl) vinyl]-2-furaldehydes with malononitrile,1,3-diethyl-2-thiobarbituric acid,or 3-phenyl-5-isoxazol one,respectively.They are characterized by 1H-NMR,FT-IR,UV-VIS,MS and elemental analysis,and have shown strong solvatochromism and high thermal stability.
2001, 12(5): 419-420
Abstract:
Several 5-[1-aryl-1,4-dihydro-6-methylpyridazin-4-one-3-yl]-2-arylamino-1,3,4-thia diazoles were synthesized.The preliminary bio-active test shows that these compounds exhibit high antifungal activity.
Several 5-[1-aryl-1,4-dihydro-6-methylpyridazin-4-one-3-yl]-2-arylamino-1,3,4-thia diazoles were synthesized.The preliminary bio-active test shows that these compounds exhibit high antifungal activity.
2001, 12(5): 421-424
Abstract:
Treatment of lappaconitine 1 with NaIO4 and Br2-HOAc at room temperature for 7 h afforded smoothly the bromine-containing derivative 4 in 71% yield.
Treatment of lappaconitine 1 with NaIO4 and Br2-HOAc at room temperature for 7 h afforded smoothly the bromine-containing derivative 4 in 71% yield.
2001, 12(5): 425-428
Abstract:
The reactions of 5,10,15,20-tetrakis (p-hydroxyphenyl) porphyrin 1 and 5-(p-hydroxy-phenyl)-10,15,20-tris (p-methoxyphenyl) porphyrin 2 with 1-bromo-2,3,4,6-O-acetyl-α-D-glu-coside 3 respectively afforded 5,10,15,20-tetrakis [p-(2,3,4,6-O-acetyl-glucoside)-1-O-phenyl] porphyrin 4 and 5,10,15-tris (p-methoxyphenyl)-20-[p-(2,3,4,6-O-acetyl-glucoside)-1-O-phenyl] porphyrin 5.Their metal complexes CoⅡ (4),MnⅡ (4) and CoⅡ (5),MnⅡ (5) also have been prepared.These new compounds have been identified by IR,UV-visible,1H NMR spectra and elemental analysis.
The reactions of 5,10,15,20-tetrakis (p-hydroxyphenyl) porphyrin 1 and 5-(p-hydroxy-phenyl)-10,15,20-tris (p-methoxyphenyl) porphyrin 2 with 1-bromo-2,3,4,6-O-acetyl-α-D-glu-coside 3 respectively afforded 5,10,15,20-tetrakis [p-(2,3,4,6-O-acetyl-glucoside)-1-O-phenyl] porphyrin 4 and 5,10,15-tris (p-methoxyphenyl)-20-[p-(2,3,4,6-O-acetyl-glucoside)-1-O-phenyl] porphyrin 5.Their metal complexes CoⅡ (4),MnⅡ (4) and CoⅡ (5),MnⅡ (5) also have been prepared.These new compounds have been identified by IR,UV-visible,1H NMR spectra and elemental analysis.
2001, 12(5): 429-430
Abstract:
The structure of a new abietane diterpenoid,taxayunnin (1),from the barks of Taxus yunnanensis,was determined by spectroscopic analysis.A known abietane diterpenoid,taxamairin C (2),was also isolated.
The structure of a new abietane diterpenoid,taxayunnin (1),from the barks of Taxus yunnanensis,was determined by spectroscopic analysis.A known abietane diterpenoid,taxamairin C (2),was also isolated.
2001, 12(5): 431-432
Abstract:
A new perylenequinone,named hypomycin A,was isolated from the mycelia of Hypomyces sp..Its structure was elucidated on the basis of spectroscopic methods.
A new perylenequinone,named hypomycin A,was isolated from the mycelia of Hypomyces sp..Its structure was elucidated on the basis of spectroscopic methods.
2001, 12(5): 433-434
Abstract:
Two new xanthone glycosides,tetraswerosides A and B,were isolated from the whole plant of Swertia tetraptera.Their structures were determined as 3-O-b-D-glucopyranosyl-1-hydroxy-4,7-dimethoxyxanthone and 3-O-[b-D-xylopyranosyl-(1→6)-b-D-glucopyranosyl]-1-hydroxy-4,7-dimethoxyxanthone by spectroscopic methods.
Two new xanthone glycosides,tetraswerosides A and B,were isolated from the whole plant of Swertia tetraptera.Their structures were determined as 3-O-b-D-glucopyranosyl-1-hydroxy-4,7-dimethoxyxanthone and 3-O-[b-D-xylopyranosyl-(1→6)-b-D-glucopyranosyl]-1-hydroxy-4,7-dimethoxyxanthone by spectroscopic methods.
2001, 12(5): 435-438
Abstract:
From the cultured filtrates of fungus Aspergillus versicolor,isolated from marine sponge Xestospongia exigua,four novel secondary metabolites,namely aspergillone 1,aspergillodiol 2, aspergillol 3 and 12-acetyl-aspergillol 4,have been isolated by column chromatographic separation.The structures of all the new compounds are established on the basis of extensive 2D NMR spectroscopy in conjugation with MS,UV spectral analysis.The basic structure pattern of those compounds possessed an hydroindenoisopyran nucleus.
From the cultured filtrates of fungus Aspergillus versicolor,isolated from marine sponge Xestospongia exigua,four novel secondary metabolites,namely aspergillone 1,aspergillodiol 2, aspergillol 3 and 12-acetyl-aspergillol 4,have been isolated by column chromatographic separation.The structures of all the new compounds are established on the basis of extensive 2D NMR spectroscopy in conjugation with MS,UV spectral analysis.The basic structure pattern of those compounds possessed an hydroindenoisopyran nucleus.
2001, 12(5): 439-442
Abstract:
A new reversed-phase packing (C18-PBD-ZrO2) was prepared by depositing and cross-linking 1-octadecene (ODE or C18) and polybutadiene (PBD) onto the surface of porous zirconia microspheres (5~10 mm in diameter) which were synthesized by a sol-gel process. These novel column packings possess high mechanical and chemical stability,wider usable pH range and can be used to separate basic compounds with no observable peak tailing.
A new reversed-phase packing (C18-PBD-ZrO2) was prepared by depositing and cross-linking 1-octadecene (ODE or C18) and polybutadiene (PBD) onto the surface of porous zirconia microspheres (5~10 mm in diameter) which were synthesized by a sol-gel process. These novel column packings possess high mechanical and chemical stability,wider usable pH range and can be used to separate basic compounds with no observable peak tailing.
2001, 12(5): 443-446
Abstract:
A new approach for the separation of antithrombin Ⅲ with high performance affinity chromatography (HPAC) was described. A novel monodisperse,non-porous,cross-linked poly (glycidyl methacrylate) beads (PGMA) were used as the affinity support. With the water-soluble carbodiimide,heparin was linked covalently to amino-PGMA-beads,which was prepared by amination of PGMA. The adsorbent obtained exhibits high binding activity to antithrombin Ⅲ (ATⅢ),good resolution and excellent mechanical properties and can be used under high flow rate.
A new approach for the separation of antithrombin Ⅲ with high performance affinity chromatography (HPAC) was described. A novel monodisperse,non-porous,cross-linked poly (glycidyl methacrylate) beads (PGMA) were used as the affinity support. With the water-soluble carbodiimide,heparin was linked covalently to amino-PGMA-beads,which was prepared by amination of PGMA. The adsorbent obtained exhibits high binding activity to antithrombin Ⅲ (ATⅢ),good resolution and excellent mechanical properties and can be used under high flow rate.
2001, 12(5): 447-448
Abstract:
Ethyldiamine bridged dimer permethy-β-CD and other cyclodextrins were used as GC stationary phase to resolute DL-pantolactone.It is found that this CD dimer has a good selectivity for DL-pantolactone.
Ethyldiamine bridged dimer permethy-β-CD and other cyclodextrins were used as GC stationary phase to resolute DL-pantolactone.It is found that this CD dimer has a good selectivity for DL-pantolactone.
2001, 12(5): 449-452
Abstract:
he in vitro interaction of nicotine and hemoglobin (Hb) in a metabolizing system was studied by spectroscopy assays. Visible spectra showed two isobestics,and fluorescence spectra showed static quenching with increasing of nicotine dose. Meanwhile,the CD spectra intensity reduced,showing the conformation of Hb varied markedly through the interaction.All these results suggested that the interaction of nicotine or its metabolites and Hb might do harm to physicological function of Hb.
he in vitro interaction of nicotine and hemoglobin (Hb) in a metabolizing system was studied by spectroscopy assays. Visible spectra showed two isobestics,and fluorescence spectra showed static quenching with increasing of nicotine dose. Meanwhile,the CD spectra intensity reduced,showing the conformation of Hb varied markedly through the interaction.All these results suggested that the interaction of nicotine or its metabolites and Hb might do harm to physicological function of Hb.
2001, 12(5): 453-456
Abstract:
Based on an unusual reversible sol-gel transition phenomenon,a novel method for the fabrication of a lipase electrode was developed.The response characteristics of the biosensor was studied by potentiometric technique using olive oil as substrate.After optimization,the lipase electrode demonstrated high activity and good stability.
Based on an unusual reversible sol-gel transition phenomenon,a novel method for the fabrication of a lipase electrode was developed.The response characteristics of the biosensor was studied by potentiometric technique using olive oil as substrate.After optimization,the lipase electrode demonstrated high activity and good stability.
2001, 12(5): 457-460
Abstract:
Monolayer formation and LB film fabrication of amphiphilic derivative of biliverdin 1,diododecyl biliverdinamide [B(CONHC12H25)2,2] at an air-water interface on pure water subphase and subphase containing calcium ion were investigated and compared with 1.The coordination in ordered molecular films is much different from that in bulk solution.The formation of ligand-calcium complex was confirmed by X-ray photoelectron spectroscopy.
Monolayer formation and LB film fabrication of amphiphilic derivative of biliverdin 1,diododecyl biliverdinamide [B(CONHC12H25)2,2] at an air-water interface on pure water subphase and subphase containing calcium ion were investigated and compared with 1.The coordination in ordered molecular films is much different from that in bulk solution.The formation of ligand-calcium complex was confirmed by X-ray photoelectron spectroscopy.
A Novel Bimetallic Tetrahedron Cobalt Complex Promot-ing the Addition of Diethylzinc to Benzaldehyde
2001, 12(5): 461-464
Abstract:
Our recent work found a novel bimetallic tetrahedron cobalt complex which can cataly-ze the addition of diethylzinc to benzaldehyde effectively.
Our recent work found a novel bimetallic tetrahedron cobalt complex which can cataly-ze the addition of diethylzinc to benzaldehyde effectively.
2001, 12(5): 465-466
Abstract:
Styrene was polymerized in supercritical (sc) CO2 with benzoyl peroxide (BPO) as initiator.It was found that the polymerization was accelerated by the external magnetic field.
Styrene was polymerized in supercritical (sc) CO2 with benzoyl peroxide (BPO) as initiator.It was found that the polymerization was accelerated by the external magnetic field.
2001, 12(5): 467-470
Abstract:
The phase behavior of a well-defined poly (methyl methacrylate)-b-polystyrene block copolymer was studied by transmission electron microscope.The results show that a microphase transition may have occurred in the copolymer film.A kind of lamellae and an ordered bicontinuous double-diamond morphology are observed clearly.The lamellar morphology reveals a larger period of about 400 nm.
The phase behavior of a well-defined poly (methyl methacrylate)-b-polystyrene block copolymer was studied by transmission electron microscope.The results show that a microphase transition may have occurred in the copolymer film.A kind of lamellae and an ordered bicontinuous double-diamond morphology are observed clearly.The lamellar morphology reveals a larger period of about 400 nm.
