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1999 Volume 10 Issue 5
1999, 10(5): 341-344
Abstract:
Abstract:Hepatitis B Virus (HBV) belongs to the family of hepadnaviridae which comprises several animal viruses, including human HBV, woodchuck hepatitis (WHV), ground squirrel hepatitis virus (GSHV) and duck hepatitis B virus (DHBV). These viruses share common features such as the genome organization, mode of replication and similar tropism for hepatocytes1. 2'-deoxyuridine-substituted biphenyl carboxylate was synthesized as anti-hepatitis B agents. The structure was confirmed by UV, 1HNMR spectrum and elementary analysis.
Abstract:Hepatitis B Virus (HBV) belongs to the family of hepadnaviridae which comprises several animal viruses, including human HBV, woodchuck hepatitis (WHV), ground squirrel hepatitis virus (GSHV) and duck hepatitis B virus (DHBV). These viruses share common features such as the genome organization, mode of replication and similar tropism for hepatocytes1. 2'-deoxyuridine-substituted biphenyl carboxylate was synthesized as anti-hepatitis B agents. The structure was confirmed by UV, 1HNMR spectrum and elementary analysis.
1999, 10(5): 345-346
Abstract:
Unexpected condensation products from β-Keto-δ-valerolactones were obtained. Their strnures were confirmed by 1HNMR spectrum and elemental analysis.
Unexpected condensation products from β-Keto-δ-valerolactones were obtained. Their strnures were confirmed by 1HNMR spectrum and elemental analysis.
1999, 10(5): 347-348
Abstract:
3-Acylcamphors were synthesized in moderate yields by the condensation of camphor with esters using sodium hydride as a base.
3-Acylcamphors were synthesized in moderate yields by the condensation of camphor with esters using sodium hydride as a base.
1999, 10(5): 349-350
Abstract:
α-Phenylsclcno-α,β-unsaturated nitrites were synthesized under mild condition via arsonium salt 1 in one pot reaction
α-Phenylsclcno-α,β-unsaturated nitrites were synthesized under mild condition via arsonium salt 1 in one pot reaction
1999, 10(5): 351-352
Abstract:
Using Fe2(SO4)3/H2SO4 as oxidant. nine N.2-diary}diazenecarboxamideswere synthesized from diarvl substituted semicarbazides in excellent yield under mild conditions for the first time. hhis method is simple, convenient and rapid.
Using Fe2(SO4)3/H2SO4 as oxidant. nine N.2-diary}diazenecarboxamideswere synthesized from diarvl substituted semicarbazides in excellent yield under mild conditions for the first time. hhis method is simple, convenient and rapid.
1999, 10(5): 353-356
Abstract:
A novel asynunetrical tri-Iert-butyl naphthalocyanine was prepared for the first time by the condensation method and by the use of structurally distorted subnaphthalocyanine. respectively The advantages of the latter method were more convenient purification and relatively higher yield.
A novel asynunetrical tri-Iert-butyl naphthalocyanine was prepared for the first time by the condensation method and by the use of structurally distorted subnaphthalocyanine. respectively The advantages of the latter method were more convenient purification and relatively higher yield.
1999, 10(5): 357-360
Abstract:
Synthesis of N6-cvclopropyl-2,6-diamino-9 β-D-arabinofuranosyl-purine has been accomplished by treatment ailylated 2-amino-6-chloro-purine 4 with 2.3.5-tri-O-benzyl-β-D-arabinofuranosyl chloride 3 in the presence of molecular sieves follwed by reaction with cyclopropylamine and debenzyl reaction to give the β-anomeric nucleoside. The structures of all products were confirmed by UV. 1H-NMR and elemental analysis.
Synthesis of N6-cvclopropyl-2,6-diamino-9 β-D-arabinofuranosyl-purine has been accomplished by treatment ailylated 2-amino-6-chloro-purine 4 with 2.3.5-tri-O-benzyl-β-D-arabinofuranosyl chloride 3 in the presence of molecular sieves follwed by reaction with cyclopropylamine and debenzyl reaction to give the β-anomeric nucleoside. The structures of all products were confirmed by UV. 1H-NMR and elemental analysis.
1999, 10(5): 361-364
Abstract:
A series of w-heterocyclyl-w-(1H-1.2.4-triazol-l-yl) acetophcnones have been synthesired. All the compounds were characteruzed by elemental analysis and spectral data. The preliminan biological test showed that some of them exhibited mild antilLngal and plant growth regulative activities.
A series of w-heterocyclyl-w-(1H-1.2.4-triazol-l-yl) acetophcnones have been synthesired. All the compounds were characteruzed by elemental analysis and spectral data. The preliminan biological test showed that some of them exhibited mild antilLngal and plant growth regulative activities.
1999, 10(5): 365-366
Abstract:
The potassium dithiocarbazate 2 was obtained through condensation of 5-pyrazole hydrazide 1 with carbon disulfide in ethanolic potassium hydroxide, and its cyclization gave 5-pyrazolyl-1,3,4-thiadiazole-2-thione 3 in concentrated sulfuric acid. Alkylation of 3 yielded 2-alkylthio-5-pyrazolyl-1,3,4-thiadiazole 4. The preliminary bioassay tests indicated that compounds 3 and 4 have fungicidal activity.
The potassium dithiocarbazate 2 was obtained through condensation of 5-pyrazole hydrazide 1 with carbon disulfide in ethanolic potassium hydroxide, and its cyclization gave 5-pyrazolyl-1,3,4-thiadiazole-2-thione 3 in concentrated sulfuric acid. Alkylation of 3 yielded 2-alkylthio-5-pyrazolyl-1,3,4-thiadiazole 4. The preliminary bioassay tests indicated that compounds 3 and 4 have fungicidal activity.
1999, 10(5): 367-370
Abstract:
Conjugated Schiff base macrocycles containing 1,3,4-oxadiaoole were prepared by[2+2] cyclic condensation of phenylenediamine with 2.5-bis(m-formyl-phenyl)-1,3,4-oxadiazole. These macrocvcles with iodine or TCNQ produced stable charge-transfer complexes. The formation of complexes were identified by UV-Vis and FT-IR spectra.
Conjugated Schiff base macrocycles containing 1,3,4-oxadiaoole were prepared by[2+2] cyclic condensation of phenylenediamine with 2.5-bis(m-formyl-phenyl)-1,3,4-oxadiazole. These macrocvcles with iodine or TCNQ produced stable charge-transfer complexes. The formation of complexes were identified by UV-Vis and FT-IR spectra.
1999, 10(5): 371-372
Abstract:
A novel poly (amide-imidc) was prepared from a novel monomer:5,6-diphenyl-chlorofitrmvl-3,4-henzenedicarboylic anhydride and his (4-aminophenyl) ether. The polymer was oharacterized by FTIR, 1FINMR. DSC and TGA.
A novel poly (amide-imidc) was prepared from a novel monomer:5,6-diphenyl-chlorofitrmvl-3,4-henzenedicarboylic anhydride and his (4-aminophenyl) ether. The polymer was oharacterized by FTIR, 1FINMR. DSC and TGA.
1999, 10(5): 373-374
Abstract:
A new active material for ECI. sensor. Ru(phen)2(phen-NHCH2Br)(PF6)2, has been designed and synthesized. Its structure was confinncd by means of IR. MS and 1H NMR. Also. some of its properties such as electrochuoistry. fluorescence and ECI, arc reported.
A new active material for ECI. sensor. Ru(phen)2(phen-NHCH2Br)(PF6)2, has been designed and synthesized. Its structure was confinncd by means of IR. MS and 1H NMR. Also. some of its properties such as electrochuoistry. fluorescence and ECI, arc reported.
1999, 10(5): 375-378
Abstract:
Usine oxidation with KMnO4. KMnO4/acetonc-H2O, NBS. followed by Polonovsky reaction and imine formation. the N-deethylatiun of sit norditerpenoid alkaloids 6-epi-forsticine yunnaconitine, 3,13-diacetylyunnacunitine, 13-dehydry-indacunitine, indacunitinc and acetylpseudaconine are reported in 36-60% yields.
Usine oxidation with KMnO4. KMnO4/acetonc-H2O, NBS. followed by Polonovsky reaction and imine formation. the N-deethylatiun of sit norditerpenoid alkaloids 6-epi-forsticine yunnaconitine, 3,13-diacetylyunnacunitine, 13-dehydry-indacunitine, indacunitinc and acetylpseudaconine are reported in 36-60% yields.
1999, 10(5): 379-382
Abstract:
Preparation of both 7,17-seco yunnaconitine derivatives 6 starting from ynnnaconitine 3 via rearrangement of chloroamine 5 is described.
Preparation of both 7,17-seco yunnaconitine derivatives 6 starting from ynnnaconitine 3 via rearrangement of chloroamine 5 is described.
1999, 10(5): 383-386
Abstract:
The cleavage activity of complexes between copper (Ⅱ)and tour different amino acid or amino acid methyl ester on DNA was tested at physiological pH and temperature. It was found that Cu (Ⅱ)-L-llis and Cu (Ⅱ)-L-llis methyl ester complexes could cleave DNA. The extent of DNN cleavage is largely dependent on the metal ion-to-ligand ratio. The cleavage of double-stranded DNA mediated by Cu (Ⅱ)-L-llis complccs occurs vin a hydrolytic mechanism.
The cleavage activity of complexes between copper (Ⅱ)and tour different amino acid or amino acid methyl ester on DNA was tested at physiological pH and temperature. It was found that Cu (Ⅱ)-L-llis and Cu (Ⅱ)-L-llis methyl ester complexes could cleave DNA. The extent of DNN cleavage is largely dependent on the metal ion-to-ligand ratio. The cleavage of double-stranded DNA mediated by Cu (Ⅱ)-L-llis complccs occurs vin a hydrolytic mechanism.
1999, 10(5): 387-388
Abstract:
The reaction between D-glucose. D-ribose and 2,2,2-trimethoxy-4,5-diphenyl-2,2-dihydro-1. 3. 2-dioxaphospholene were investigated by 31P NMR and FAB-MS. The results showed that there were a lot of differences in the reactions via pentacoordinate phosphorus compound. and it should give significant clue to the metabolism of carbohydrate phosphate in nature.
The reaction between D-glucose. D-ribose and 2,2,2-trimethoxy-4,5-diphenyl-2,2-dihydro-1. 3. 2-dioxaphospholene were investigated by 31P NMR and FAB-MS. The results showed that there were a lot of differences in the reactions via pentacoordinate phosphorus compound. and it should give significant clue to the metabolism of carbohydrate phosphate in nature.
1999, 10(5): 389-390
Abstract:
A new triterpenoid saponin, named prostratoside A, vvas isolated from the whole plants of Polycmpon prostratuna. Its structure was determined to be 3-0-{β-D-xylopyranosyl-(1→2)-β-D-glucopyranosyl-(1→4)-[β-D-glucopyranosyl-(1→2)-β-D-g lucopyranosyl-(1→4)-[β-D-glucopyranosyl-(1→2)]-α-L-arabinopyranosyl}-22α-acetosy-saikogenin G by spectroscopic methods.
A new triterpenoid saponin, named prostratoside A, vvas isolated from the whole plants of Polycmpon prostratuna. Its structure was determined to be 3-0-{β-D-xylopyranosyl-(1→2)-β-D-glucopyranosyl-(1→4)-[β-D-glucopyranosyl-(1→2)-β-D-g lucopyranosyl-(1→4)-[β-D-glucopyranosyl-(1→2)]-α-L-arabinopyranosyl}-22α-acetosy-saikogenin G by spectroscopic methods.
1999, 10(5): 391-394
Abstract:
Two new triterpenoid saponins, tanguticosidc A and B were isolated from aerial part of Clematis tangutica. Their structures were elucidated as 3-0-β->D-glucopyranosylhcderagenin 28-O-α-L-rhamnopyranosyl-(1→4)-β->D-glucopyranosyl-(1→6)-β->D-glucopyranoside 1 and 3-O-β->D-glucopyranosy-(1→2)-β->D-glucopyranosyl hederagenin 28-O-α-L-rhamnopyranosyl-(1→4)-β->D-glucopyranosyl-(1→6)-β->D-glucopyranosidc 2, respcctively.
Two new triterpenoid saponins, tanguticosidc A and B were isolated from aerial part of Clematis tangutica. Their structures were elucidated as 3-0-β->D-glucopyranosylhcderagenin 28-O-α-L-rhamnopyranosyl-(1→4)-β->D-glucopyranosyl-(1→6)-β->D-glucopyranoside 1 and 3-O-β->D-glucopyranosy-(1→2)-β->D-glucopyranosyl hederagenin 28-O-α-L-rhamnopyranosyl-(1→4)-β->D-glucopyranosyl-(1→6)-β->D-glucopyranosidc 2, respcctively.
1999, 10(5): 395-396
Abstract:
Continuing investigation of Delphinium souliei Pranch yielded wo minor new ditcrpcnoid alkaloids-soulinc E(1)and souline F(2). their structures were determined on the basis of spectroscopic evidences.
Continuing investigation of Delphinium souliei Pranch yielded wo minor new ditcrpcnoid alkaloids-soulinc E(1)and souline F(2). their structures were determined on the basis of spectroscopic evidences.
1999, 10(5): 397-400
Abstract:
A new triterpenoid glycoside, named decaisosidz F. has been isolated from Decaisnea fargesii. Its structure was determined on basis of chemical method. FBA-MS. homonuclear and heteronuclear correlation esperiwnts. including 1H-1H COSY. 1H-13C COSY. TOSCY. HMBC and NOESY techniques to be 3-O-β->D-xylopyranosy (1→3)-α-L-arhamnopyranosyl (1→3)-α-L-arabinopyranosvi hederagenin 28-O-β->D-xylopyranosyl (1→4)-β->D-glucopyranosyl(1→β-D-glucopyranoside.
A new triterpenoid glycoside, named decaisosidz F. has been isolated from Decaisnea fargesii. Its structure was determined on basis of chemical method. FBA-MS. homonuclear and heteronuclear correlation esperiwnts. including 1H-1H COSY. 1H-13C COSY. TOSCY. HMBC and NOESY techniques to be 3-O-β->D-xylopyranosy (1→3)-α-L-arhamnopyranosyl (1→3)-α-L-arabinopyranosvi hederagenin 28-O-β->D-xylopyranosyl (1→4)-β->D-glucopyranosyl(1→β-D-glucopyranoside.
1999, 10(5): 401-402
Abstract:
A novel eleven-membered heterocyclic compound with high nitrogen has been isolated from the marine alga Sargassum vachell collected from the South China Sea. Its structure has been established by verity of spectroscopic techniques such as IR. EIMS. ID NMR. 1H-1HCOSY. HMQC. HMBC.
A novel eleven-membered heterocyclic compound with high nitrogen has been isolated from the marine alga Sargassum vachell collected from the South China Sea. Its structure has been established by verity of spectroscopic techniques such as IR. EIMS. ID NMR. 1H-1HCOSY. HMQC. HMBC.
1999, 10(5): 403-406
Abstract:
A kinetic method is described for the determination of trace amounts of maneancse(Ⅱ) based on its catalytic effect on the aerial oxidation of 1.5-bis (2-hydrox)-5-chlorophenyl)-3-cyanofonnazan. The reaction is followed spcctrophotometrically by measuring the rate of change in absorbancc at 580nm. The calibration curve (rate constant vs. manganese concentration) is linear in the range of 10~200ng in 25ml solutions. Kinetic parameters of the reaction arc reported. There are few interfcrences.
A kinetic method is described for the determination of trace amounts of maneancse(Ⅱ) based on its catalytic effect on the aerial oxidation of 1.5-bis (2-hydrox)-5-chlorophenyl)-3-cyanofonnazan. The reaction is followed spcctrophotometrically by measuring the rate of change in absorbancc at 580nm. The calibration curve (rate constant vs. manganese concentration) is linear in the range of 10~200ng in 25ml solutions. Kinetic parameters of the reaction arc reported. There are few interfcrences.
1999, 10(5): 407-410
Abstract:
The oxidation of ethanol in 1.0 mol/L NaOH was studied on Pd/GC electrode prepared by electrodeposition. The results show that (1) Pd/GC electrode can also demonstrate electrocatalytic activity towards the oxidation of ethanol:(2) two backward anodic peaks on the cathodic branch appear when the ethanol concentration is raised up to 0.5 mol/L.
The oxidation of ethanol in 1.0 mol/L NaOH was studied on Pd/GC electrode prepared by electrodeposition. The results show that (1) Pd/GC electrode can also demonstrate electrocatalytic activity towards the oxidation of ethanol:(2) two backward anodic peaks on the cathodic branch appear when the ethanol concentration is raised up to 0.5 mol/L.
1999, 10(5): 411-414
Abstract:
3-Indolyl acetate can be solubilized in dilute ayueous solution of beta cyclodextrin. due to the formation of host-guest complex through hydrophobic interaction between the indolyl group and the inside cave of the cyclodextrin molecule.The thermodynamic parameters of the complexing process can be estimated utilizing the spectrophotometric data.
3-Indolyl acetate can be solubilized in dilute ayueous solution of beta cyclodextrin. due to the formation of host-guest complex through hydrophobic interaction between the indolyl group and the inside cave of the cyclodextrin molecule.The thermodynamic parameters of the complexing process can be estimated utilizing the spectrophotometric data.
1999, 10(5): 415-418
Abstract:
A molecular mechanics field, Alchemy 1l, was utilized to model the chiral recognition between S-N-acetyl-α-methyl-I-naphthylamine and (R, S)-N-(3, 5-dinitrophenyl)-α-methyl-benzeneacetamide and between β-cyclodextrin and (R, S)-fenoprofen. Some preliminary results have been obtained to sustain the three-point action models and the induce-tit action in enantiorecogmtion.
A molecular mechanics field, Alchemy 1l, was utilized to model the chiral recognition between S-N-acetyl-α-methyl-I-naphthylamine and (R, S)-N-(3, 5-dinitrophenyl)-α-methyl-benzeneacetamide and between β-cyclodextrin and (R, S)-fenoprofen. Some preliminary results have been obtained to sustain the three-point action models and the induce-tit action in enantiorecogmtion.
1999, 10(5): 419-420
Abstract:
The crystallization behavior of poly (3-dodecylthiophene) (P3DDT) is studied by differential scanning calorimetry (DSC) under different cooling rates. When the methods of Jeziorw.Ozawa and a new one proposed by our laboratory are applied to describe its nonisothermal crystallization behavior. the new one is confirmed to be the best and convenient. By determining kinetic parameters. the analysis of the nonisothermal crystallization behavior is performed. According to Kissinger method. the crystallization activation energy of P3DDT is also evaluated.
The crystallization behavior of poly (3-dodecylthiophene) (P3DDT) is studied by differential scanning calorimetry (DSC) under different cooling rates. When the methods of Jeziorw.Ozawa and a new one proposed by our laboratory are applied to describe its nonisothermal crystallization behavior. the new one is confirmed to be the best and convenient. By determining kinetic parameters. the analysis of the nonisothermal crystallization behavior is performed. According to Kissinger method. the crystallization activation energy of P3DDT is also evaluated.
1999, 10(5): 421-424
Abstract:
A new self-assembled monolayer (SAM) of fullerene derivative has been fabricated and their photoelectric conversion property has been observed. The SAM was fabricated on indium-tin-oxide (ITO) and quartz by amide bonding. It was characterized by contact angle, UV spectrum, and cyclic voltammetrv.The mild fabrication conditions and the stability of the SAM provides a way to build three-dimensional structure more easily.
A new self-assembled monolayer (SAM) of fullerene derivative has been fabricated and their photoelectric conversion property has been observed. The SAM was fabricated on indium-tin-oxide (ITO) and quartz by amide bonding. It was characterized by contact angle, UV spectrum, and cyclic voltammetrv.The mild fabrication conditions and the stability of the SAM provides a way to build three-dimensional structure more easily.
1999, 10(5): 425-428
Abstract:
A series of yttrium metallofullerenes. some of them are first reported. have been synthesized by the DC arc discharge method at high helium pressure. Mass spectra results show that the contents of metallofullerenes are very high both in primary soot and in CS2 or DMF extract and Y@C82 with ca. 85% purity is obtained through column chromatographic isolation.
A series of yttrium metallofullerenes. some of them are first reported. have been synthesized by the DC arc discharge method at high helium pressure. Mass spectra results show that the contents of metallofullerenes are very high both in primary soot and in CS2 or DMF extract and Y@C82 with ca. 85% purity is obtained through column chromatographic isolation.
1999, 10(5): 429-432
Abstract:
A complex of N.N'-ethylenebis (salicylidenciminato) diaquochromium(Ⅲ) chloride.[Cr (salen) (H2O)2] Cl was prepared, and its decomposition mechanism was studied by TG and DTA. The IR spectrum of the product of thermal decomposition was examined at the first stage Kinetic results were obtained from the analysis of TG-DTG curves with three different methods The most probable kinetic functions were suggested by comparison of kinetic parameters.
A complex of N.N'-ethylenebis (salicylidenciminato) diaquochromium(Ⅲ) chloride.[Cr (salen) (H2O)2] Cl was prepared, and its decomposition mechanism was studied by TG and DTA. The IR spectrum of the product of thermal decomposition was examined at the first stage Kinetic results were obtained from the analysis of TG-DTG curves with three different methods The most probable kinetic functions were suggested by comparison of kinetic parameters.
1999, 10(5): 433-434
Abstract:
A novel ammonia-synthesis catalyst, potassium-promoted ruthenium supported on fullerene (K-Ru/C60/70), was prepared and evaluated. It was found that K-Ru/C60/70 was the most active catalyst for ammonia synthesis at atmospheric pressure and 623 K compared with other support materials such as silica, activated carbon, zeolite, γ-Al2O3 and rare earth metal oxide.
A novel ammonia-synthesis catalyst, potassium-promoted ruthenium supported on fullerene (K-Ru/C60/70), was prepared and evaluated. It was found that K-Ru/C60/70 was the most active catalyst for ammonia synthesis at atmospheric pressure and 623 K compared with other support materials such as silica, activated carbon, zeolite, γ-Al2O3 and rare earth metal oxide.
