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1993 Volume 4 Issue 12
1993, 4(12): 1035-1036
Abstract:
Intramolecular cyclization of A catalyzed by IDA in benzene or THF yields two γ-lactams through C-alkylation and one δ- and one 7-membered lactam by O-alkylation.
Intramolecular cyclization of A catalyzed by IDA in benzene or THF yields two γ-lactams through C-alkylation and one δ- and one 7-membered lactam by O-alkylation.
1993, 4(12): 1037-1038
Abstract:
When the title compound was treated in protic solvent with alkali catalyses, γ-lacatam was almost the sole product. The ratio of ketone 1 to ketone 2 depended upon the reaction condition.
When the title compound was treated in protic solvent with alkali catalyses, γ-lacatam was almost the sole product. The ratio of ketone 1 to ketone 2 depended upon the reaction condition.
1993, 4(12): 1039-1040
Abstract:
In the reaction of Pyrromethenone with bromine in methanol a new compound with two azafulvenes, 16.24-dehydrobiladiene-ab, was first investigated.
In the reaction of Pyrromethenone with bromine in methanol a new compound with two azafulvenes, 16.24-dehydrobiladiene-ab, was first investigated.
1993, 4(12): 1041-1042
Abstract:
The synthesis and properties of a novel of macrocycle H6L derived from succinic dihydrazide and 2, 6-diformyl-4-methylphenol was described. From the NMR resuli the macrocycle was supposed to exist in solution as a equilibrium of ketone and enol.
The synthesis and properties of a novel of macrocycle H6L derived from succinic dihydrazide and 2, 6-diformyl-4-methylphenol was described. From the NMR resuli the macrocycle was supposed to exist in solution as a equilibrium of ketone and enol.
1993, 4(12): 1043-1046
Abstract:
Three methods for synthesis of benzotellurazole crown ether (6) are described. The cyanine dye (8) can be easily obtained by treating (6) with CH3I and CH (OEt)a.
Three methods for synthesis of benzotellurazole crown ether (6) are described. The cyanine dye (8) can be easily obtained by treating (6) with CH3I and CH (OEt)a.
1993, 4(12): 1047-1050
Abstract:
1-Isocyano substituted benzylphosphonates were prepared by dehydration of 1-N-formylamino substituted benzylphosphonates, which were obtained by a tricomponental condensation described by us. Mean-while addition of diethyl phosphite to N-trityl aldimine followed by deprotection, formylation and dehydration gave corresponding 1-isocyano alkylphosphonates in one-pot procedure.
1-Isocyano substituted benzylphosphonates were prepared by dehydration of 1-N-formylamino substituted benzylphosphonates, which were obtained by a tricomponental condensation described by us. Mean-while addition of diethyl phosphite to N-trityl aldimine followed by deprotection, formylation and dehydration gave corresponding 1-isocyano alkylphosphonates in one-pot procedure.
1993, 4(12): 1051-1052
Abstract:
Arenesulfonyl chloride undergoes a facile one-pot coupling reaction with active halides assisted by zinc to give the corresponding sulfones in acceptable yields.
Arenesulfonyl chloride undergoes a facile one-pot coupling reaction with active halides assisted by zinc to give the corresponding sulfones in acceptable yields.
1993, 4(12): 1053-1056
Abstract:
Some nucleoside carhoxylic acid derivatives, such as (±) ethyl ester of griseolic acid D (4) and 9-(2'-deoxy-2'-(benzyloxycarbonyl)-methylene-β-D-rihohept-2'-enofuranosyluranate) adenine (11), were synthesized. The formation of lactone of 5'-deoxy-adenosineacetic acid (AAA, 3) was investigated by using different reagents for lactonization from AAA, but all of the efforts failed, and some unexpected compounds were obtained.
Some nucleoside carhoxylic acid derivatives, such as (±) ethyl ester of griseolic acid D (4) and 9-(2'-deoxy-2'-(benzyloxycarbonyl)-methylene-β-D-rihohept-2'-enofuranosyluranate) adenine (11), were synthesized. The formation of lactone of 5'-deoxy-adenosineacetic acid (AAA, 3) was investigated by using different reagents for lactonization from AAA, but all of the efforts failed, and some unexpected compounds were obtained.
1993, 4(12): 1057-1060
Abstract:
Five novel bis-(N-alkyl-N, N-dimethyl ammonium) polyethyleneglyool ether salts prepared by our previously reported procedare show high catalytic efficiency in the condensation of 1, 4-diacetyl-2, 5-piperazinedione and aldehydes at both higher and lower temperature even in lower concentration. They also show catalytic selectivity at lower temperature.
Five novel bis-(N-alkyl-N, N-dimethyl ammonium) polyethyleneglyool ether salts prepared by our previously reported procedare show high catalytic efficiency in the condensation of 1, 4-diacetyl-2, 5-piperazinedione and aldehydes at both higher and lower temperature even in lower concentration. They also show catalytic selectivity at lower temperature.
1993, 4(12): 1061-1064
Abstract:
Oxidative dehydrogenation of propane over V-Mg-O and MCln (M=Cu+, Li+, Ag+, Cd2+) promoted V-Mg-O catalysts was studied. XRD result showed that the V-Mg-Ocatalysts were composed of MgO and Mg3(VO4)2. The yield of propene was much higher over CuCl and LiCl promoted VMgO catalysts than that over VMgO catalysts at the same reaction temperature. The highest yield of propene reached 23.1% at 500℃ and 6000h-1 space velocity.
Oxidative dehydrogenation of propane over V-Mg-O and MCln (M=Cu+, Li+, Ag+, Cd2+) promoted V-Mg-O catalysts was studied. XRD result showed that the V-Mg-Ocatalysts were composed of MgO and Mg3(VO4)2. The yield of propene was much higher over CuCl and LiCl promoted VMgO catalysts than that over VMgO catalysts at the same reaction temperature. The highest yield of propene reached 23.1% at 500℃ and 6000h-1 space velocity.
1993, 4(12): 1065-1066
Abstract:
A new antitumor glycocyclohexapcptide, RY-Ⅲ, was isolated from Rubia yunnanensis. The structure of RY-Ⅲ was elucidated by means of spectral methods.
A new antitumor glycocyclohexapcptide, RY-Ⅲ, was isolated from Rubia yunnanensis. The structure of RY-Ⅲ was elucidated by means of spectral methods.
1993, 4(12): 1067-1070
Abstract:
Two new alkaloids namely tuberostemoninal and tuberostemoamide as minor components were isolated from the roots of Stemona tuberosa. Their structures were determined by various 2D NMR and other spectra and finally confirmed by X-ray analysis.
Two new alkaloids namely tuberostemoninal and tuberostemoamide as minor components were isolated from the roots of Stemona tuberosa. Their structures were determined by various 2D NMR and other spectra and finally confirmed by X-ray analysis.
1993, 4(12): 1071-1074
Abstract:
A high-performance liquid chromatographic method for the simultaneous determination of KR-008 and its metabolite in biological fluids was developed The samples were injected directly without further treatment, the compounds were separated and analysed on a reversedphase column under isocratic conditions, including ion pairing. Concentrations in urine and bile were determined by an external standard method. The detection limit was 0.8μg/ml in urine. Preliminary data showed that, following i. p. administration (120mg/kg) of KR-008 to rats, approximately 2.8% of the dose was excreted in urine as unchanged compound and more than 8.9% was as a metabolite;in bbile it was 0.73% excreted as unchanged form and above 0.29% as the metabolite. The peak biliary concentration of KR-008 was 0.39mg/ml at 20min after dosing.
A high-performance liquid chromatographic method for the simultaneous determination of KR-008 and its metabolite in biological fluids was developed The samples were injected directly without further treatment, the compounds were separated and analysed on a reversedphase column under isocratic conditions, including ion pairing. Concentrations in urine and bile were determined by an external standard method. The detection limit was 0.8μg/ml in urine. Preliminary data showed that, following i. p. administration (120mg/kg) of KR-008 to rats, approximately 2.8% of the dose was excreted in urine as unchanged compound and more than 8.9% was as a metabolite;in bbile it was 0.73% excreted as unchanged form and above 0.29% as the metabolite. The peak biliary concentration of KR-008 was 0.39mg/ml at 20min after dosing.
1993, 4(12): 1075-1078
Abstract:
The electrochemical behavior of nitrofurazone in dimethylformamide has been studied by cyclic voltammetry and in-situ thin-layer spectroelectrochemistry. The redox reactions are complicated at platinium electrode, and a possible electrochemical mechanism of nitrofurazone is proposed.
The electrochemical behavior of nitrofurazone in dimethylformamide has been studied by cyclic voltammetry and in-situ thin-layer spectroelectrochemistry. The redox reactions are complicated at platinium electrode, and a possible electrochemical mechanism of nitrofurazone is proposed.
1993, 4(12): 1079-1080
Abstract:
A new dye-staining method for protein assay is described. The reaction between TPPS4 and protein molecule causes a shift in the absorption of TPPS4 from 435 nm to 488 nm. The absorbance at 488 nm is proportional to the concentration of protein. The range of Beer's law was 1-5 ug/ml and the Sandell's sensitivity was 0.0087 ug/cm2.
A new dye-staining method for protein assay is described. The reaction between TPPS4 and protein molecule causes a shift in the absorption of TPPS4 from 435 nm to 488 nm. The absorbance at 488 nm is proportional to the concentration of protein. The range of Beer's law was 1-5 ug/ml and the Sandell's sensitivity was 0.0087 ug/cm2.
1993, 4(12): 1081-1084
Abstract:
Five phospholipids in human placenta were determined by phosphorus 31 nuclear magnetic resonance (31P NMR) spectroscopy and thin-layer chromatography (TLC) scanning combined with the corrective method of absorbance proportional coefficient. The NMR spectrometer used this investigation was a Bruker AM-500 spectrometeroperating at 202.4 MHz for 31P chemical shifts are relative to 85% phosphoric acid. TIC was carried out by silica gel H plate developed in chloroform-methanol-glacialacetic acid-ethanol-water (25:4:6:2:0.5), with Vaskovsky reagent as colour-developing agent of phospholipids.
Five phospholipids in human placenta were determined by phosphorus 31 nuclear magnetic resonance (31P NMR) spectroscopy and thin-layer chromatography (TLC) scanning combined with the corrective method of absorbance proportional coefficient. The NMR spectrometer used this investigation was a Bruker AM-500 spectrometeroperating at 202.4 MHz for 31P chemical shifts are relative to 85% phosphoric acid. TIC was carried out by silica gel H plate developed in chloroform-methanol-glacialacetic acid-ethanol-water (25:4:6:2:0.5), with Vaskovsky reagent as colour-developing agent of phospholipids.
1993, 4(12): 1085-1088
Abstract:
The nature of the quenching of barbiturate fluorescence by forming inclusion complexcs with β-cyclodextrin is investigated principally using fluorescence/absorption and Fourier transform infrared (FTIR) spectroscopy. The relatively weak complexes formed in aqueous solutions indicated through the IR spectroscopies are confirmed by the apparent formation constants acquired by using fluorescence method. Further specific information concerning the mechanisms of interaction has been explored in detail by means of the analysis of the electrochemical and spectroscopic behaviour.
The nature of the quenching of barbiturate fluorescence by forming inclusion complexcs with β-cyclodextrin is investigated principally using fluorescence/absorption and Fourier transform infrared (FTIR) spectroscopy. The relatively weak complexes formed in aqueous solutions indicated through the IR spectroscopies are confirmed by the apparent formation constants acquired by using fluorescence method. Further specific information concerning the mechanisms of interaction has been explored in detail by means of the analysis of the electrochemical and spectroscopic behaviour.
1993, 4(12): 1089-1092
Abstract:
The pH dependence of Zinc (Ⅱ) tetrasulfonated phthalocyanine in aqueous solution has been investigated. The tendency of dimerization was enhanced by the addition of HCl, with blue-shifted peaks appearing in the Q band as well as the Soret band region. And the demetallation of metallophthalocyanines caused by the acid was confirmed by spectroscopic evidence for the first time. The effect caused by NaOH was also discussed.
The pH dependence of Zinc (Ⅱ) tetrasulfonated phthalocyanine in aqueous solution has been investigated. The tendency of dimerization was enhanced by the addition of HCl, with blue-shifted peaks appearing in the Q band as well as the Soret band region. And the demetallation of metallophthalocyanines caused by the acid was confirmed by spectroscopic evidence for the first time. The effect caused by NaOH was also discussed.
1993, 4(12): 1093-1096
Abstract:
Electron microscope and electron diffraction have been used to study epitaxial crystallization of poly (ε-caprolactone) (PCL). on highly oriented film of isotactic polypropylene (iPP). The results obtained from bright field (BF) electron micrograph and electron diffraction indicate that the PCL can epitaxially grow on iPP substrate and form cross-hatched lamellar texture. The c axes of PCL are ±50° apart from the c axes of iPP. The contact planes of the two kinds of crystals are (010) of iPP and (100) of PCL, respectively.
Electron microscope and electron diffraction have been used to study epitaxial crystallization of poly (ε-caprolactone) (PCL). on highly oriented film of isotactic polypropylene (iPP). The results obtained from bright field (BF) electron micrograph and electron diffraction indicate that the PCL can epitaxially grow on iPP substrate and form cross-hatched lamellar texture. The c axes of PCL are ±50° apart from the c axes of iPP. The contact planes of the two kinds of crystals are (010) of iPP and (100) of PCL, respectively.
1993, 4(12): 1097-1100
Abstract:
The stabilities of the complexes of three pyridine-like ligands with M(Ⅱ)(ATP)2- and M(Ⅱ)(M=Ni, Co) were studied by spectrophotometry and by comparing the stability constants of the ternary complexes with those of the binary complexes. A stacking interaction between the pyridine ring and the purine ring of ATP is indicated. The general existence of the stacking interaction encourages us to interpret the antitumor mechanism of a new class of antitumor drugs.
The stabilities of the complexes of three pyridine-like ligands with M(Ⅱ)(ATP)2- and M(Ⅱ)(M=Ni, Co) were studied by spectrophotometry and by comparing the stability constants of the ternary complexes with those of the binary complexes. A stacking interaction between the pyridine ring and the purine ring of ATP is indicated. The general existence of the stacking interaction encourages us to interpret the antitumor mechanism of a new class of antitumor drugs.
1993, 4(12): 1101-1104
Abstract:
In this paper, the nanrelativistic and relativistic pseudo-potentials (i.e. HF-MEFIT-PP and WB-MEFIT-PP) for Cd were used to calculate the potential curves of the six Low-Lying states of CdF system. Furthermore, we carried out their spectroscopic constants (R., Do, T., and ω.). Based on the above results, the relativistic effects on the spectroscopic constants were discussed.
In this paper, the nanrelativistic and relativistic pseudo-potentials (i.e. HF-MEFIT-PP and WB-MEFIT-PP) for Cd were used to calculate the potential curves of the six Low-Lying states of CdF system. Furthermore, we carried out their spectroscopic constants (R., Do, T., and ω.). Based on the above results, the relativistic effects on the spectroscopic constants were discussed.
1993, 4(12): 1105-1108
Abstract:
A Titanium tetrachloride-1-methyl-3-ethytimidazolium chloride melt has been prepared. The reduction process of Ti (Ⅳ) appears to be diffusion controlled in the composition of 0.4:1 mole ralio of TiCl4-1-methyl-3-ethylimidazolium chloride and the electrochemical behavior of Ti (Ⅳ) shows remarkable compositon dependence.
A Titanium tetrachloride-1-methyl-3-ethytimidazolium chloride melt has been prepared. The reduction process of Ti (Ⅳ) appears to be diffusion controlled in the composition of 0.4:1 mole ralio of TiCl4-1-methyl-3-ethylimidazolium chloride and the electrochemical behavior of Ti (Ⅳ) shows remarkable compositon dependence.
1993, 4(12): 1109-1112
Abstract:
Various species of Cu. Pb, Zn and Cr in dust of different origins and diameters were studied using Tessler scheme, and the partition law was revealed, The results indicated that superior form of Cu、Pb、Zn and Cr was bound to organic master, bound to Fe-Mn oxides, bound to Fe-Mn oxides and residual. So their activity order was Zn >Pb >Cu >Cr. The exchangeable metals bound to carbonates and Fe-Mn oxides of four heavy metals in small particles were superior to those in large particles, which illustrated that heavy metals in small paticles were more active and harmful.
Various species of Cu. Pb, Zn and Cr in dust of different origins and diameters were studied using Tessler scheme, and the partition law was revealed, The results indicated that superior form of Cu、Pb、Zn and Cr was bound to organic master, bound to Fe-Mn oxides, bound to Fe-Mn oxides and residual. So their activity order was Zn >Pb >Cu >Cr. The exchangeable metals bound to carbonates and Fe-Mn oxides of four heavy metals in small particles were superior to those in large particles, which illustrated that heavy metals in small paticles were more active and harmful.
