A photothermal agent (ECEI) with high photothermal conversion efficiency (85.78%) was synthesized based on coumarin fluorescent groups. In addition, the experimental results of hot and cold cycling show that ECEI has good photostability. Despite damage to the mitochondrial membrane potential, ECEI can effectively target mitochondria and induce cancer cell death under laser irradiation. This allows ECEI to maximize mitochondrial damage and thus inhibit tumor cell reproduction. Notable, after irradiating mouse tumors once, the mouse tumors gradually disappeared within 10 d. This indicates that ECEI has an excellent tumor inhibition effect.

卤代烃E2消除反应是基础有机化学课程中的重要教学内容，由于缺乏直观形象化的描述导致学生理解困难。本文设计了一个面向化学本科专业的计算化学实验，通过量子化学计算阐明卤代烃发生E2消除反应的详细机理及其与S_N2亲核取代反应的竞争机制，同时获取反应的热力学和动力学信息，帮助学生理解Zaitsev规则、选择性、反应热力学、反应动力学、过渡态、反应坐标等有机化学及物理化学中的基本概念。本实验旨在训练学生使用计算化学方法解决化学问题的基本思路，提升学生的科研素养。