Bovine serum albumin (BSA) and glycine (Gly) dual-ligand-modified copper nanoclusters (BSA-Gly CuNCs) with high fluorescence intensity were synthesized by a one-pot strategy. Based on the competitive fluorescence quenching and dynamic quenching effects of ornidazole (ONZ) on BSA-Gly CuNCs, a simple and sensitive detection method for ONZ was successfully developed. The experimental results demonstrate that the addition of the small molecule Gly can more effectively protect CuNCs, and thus enhance its fluorescence intensity and stability. The proposed assay allowed for the detection of ONZ in a linear range of 0.28 to 52.60 μmol·L^-1 and a detection limit of 0.069 μmol·L^-1. Compared with the single-ligand-modified CuNCs, dual-ligand-modified BSA-Gly CuNCs had higher fluorescence intensity, stability, and sensing ability and were successfully applied to evaluate ONZ in actual ONZ tablets.

从学生解题角度出发，对第37届中国化学奥林匹克(初赛)试题中的有机化学第9和10题进行了全面详尽的分析，这可以培养学生的逻辑思维能力，进而提高学生解决有机化学问题的效率。同时，通过深入学习反应机理，帮助学生体会题目背后的科学思维，感受有机化学的魅力与乐趣。

设计、合成了一种基于巴比妥酸衍生物的具有D-π-A结构的光学探针3。该探针能够作为一种高度灵敏和选择性的次氯酸指示剂，快速实现对次氯酸的比色和荧光信号(开-关)的双响应(约15 s)。推测的响应机制是ClO^-与C=C之间发生了亲电加成和氧化裂解反应，导致探针的D-π-A结构遭到破坏，从而阻断了其分子内电荷转移(intramolecular charge transfer，ICT)进程。探针只需一步即可合成，同时具有红光发射(628 nm)和较大的斯托克斯位移(158 nm)，检测限(limit of detection，LOD)低至14 nmol·L^-1。此外，探针还表现出低细胞毒性，并成功应用于活细胞成像。

皮克林乳液——一种由胶体尺寸固体颗粒稳定水油界面所形成的乳液——是科学研究和生活生产的热点话题。本文对“皮克林乳液”这一概念进行科普，介绍了传统乳液和皮克林乳液的基本概念、形成原理、制备方法、实验室表征结果及在光催化等领域的应用等，让大学生、青少年、幼小学生乃至社会大众通过皮克林乳液体会化学之美和化学之趣。

Herein, copper nanoclusters (Cu NCs) were synthesized in aqueous solution through a chemical reduction method using polyethyleneimine as reducing agent and protective ligand, with Cu(NO₃)₂ as copper source. Subsequently, composite fluorescent nanoparticles, chitosan-functionalized silica nanoparticles (CSNPs)-coated Cu NCs (Cu NCs/CSNPs), were synthesized via a reverse microemulsion method. Compared with Cu NCs, the composite Cu NCs/CSNPs exhibited an increased quantum yield and enhanced fluorescence sensing performance. Based on the composite Cu NCs/CSNPs, a fluorescence method for the detection of cefixime fluorescence quenching was established. The technique was simple, sensitive, and selective for detecting cefixime. The fluorescence quenching efficiency of Cu NCs/CSNPs was linearly related to the concentration of cefixime in the range of 3.98-38.5 μmol·L^-1 (1.81-17.46 mg·L^-1), with a limit of detection of 0.045 5 μmol·L^-1 (20.6 μg·L^-1).