引用本文:
Bao Liu, Qi Dong You, Zhi Yu Li. Design, synthesis and antitumor activity of 6,7-disubstituted-4-(heteroarylamino) quinoline-3-carbonitrile derivatives[J]. Chinese Chemical Letters,
2010, 21(5): 554-557.
doi:
10.1016/j.cclet.2010.01.016
Citation: Bao Liu, Qi Dong You, Zhi Yu Li. Design, synthesis and antitumor activity of 6,7-disubstituted-4-(heteroarylamino) quinoline-3-carbonitrile derivatives[J]. Chinese Chemical Letters, 2010, 21(5): 554-557. doi: 10.1016/j.cclet.2010.01.016
Citation: Bao Liu, Qi Dong You, Zhi Yu Li. Design, synthesis and antitumor activity of 6,7-disubstituted-4-(heteroarylamino) quinoline-3-carbonitrile derivatives[J]. Chinese Chemical Letters, 2010, 21(5): 554-557. doi: 10.1016/j.cclet.2010.01.016
Design, synthesis and antitumor activity of 6,7-disubstituted-4-(heteroarylamino) quinoline-3-carbonitrile derivatives
摘要:
A series of new 6,7-disubstituted-4-(benzothiazol-6-ylamino)quinoline-3-carbonitrile derivatives (12a-l) were synthesized. The cytotoxicity of 12 new compounds was evaluated in AGS, HepG2 and HT-29 cell lines. The results showed that compounds 12g,12h, 12i, 12k and 12l displayed more potent cytotoxic activities than Bosutinib, compound 12l exhibited the most potent antitumor activity among the tested compounds.
English
Design, synthesis and antitumor activity of 6,7-disubstituted-4-(heteroarylamino) quinoline-3-carbonitrile derivatives
Abstract:
A series of new 6,7-disubstituted-4-(benzothiazol-6-ylamino)quinoline-3-carbonitrile derivatives (12a-l) were synthesized. The cytotoxicity of 12 new compounds was evaluated in AGS, HepG2 and HT-29 cell lines. The results showed that compounds 12g,12h, 12i, 12k and 12l displayed more potent cytotoxic activities than Bosutinib, compound 12l exhibited the most potent antitumor activity among the tested compounds.
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Key words:
- 3-Quinolinecarbonitrile derivatives
- / Synthesis
- / Antitumor
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