引用本文:
李元祥, 陈迪钊. N-(2-(腈基(4,6-二甲氧基嘧啶-2-基)甲基)苯基)酰胺类衍生物的合成及生物活性[J]. 应用化学,
2013, 30(9): 999-1004.
doi:
10.3724/SP.J.1095.2013.20541
Citation: LI Yuanxiang, CHEN Dizhao. Synthesis and Biological Activities of N-(2-(Cyano(4,6dimethoxypyrimidin-2-yl) methyl) phenyl) Substitued Amide Derivatives[J]. Chinese Journal of Applied Chemistry, 2013, 30(9): 999-1004. doi: 10.3724/SP.J.1095.2013.20541
Citation: LI Yuanxiang, CHEN Dizhao. Synthesis and Biological Activities of N-(2-(Cyano(4,6dimethoxypyrimidin-2-yl) methyl) phenyl) Substitued Amide Derivatives[J]. Chinese Journal of Applied Chemistry, 2013, 30(9): 999-1004. doi: 10.3724/SP.J.1095.2013.20541
N-(2-(腈基(4,6-二甲氧基嘧啶-2-基)甲基)苯基)酰胺类衍生物的合成及生物活性
English
Synthesis and Biological Activities of N-(2-(Cyano(4,6dimethoxypyrimidin-2-yl) methyl) phenyl) Substitued Amide Derivatives
Abstract:
Six novel N-(2-(cyano(4,6-dimethoxypyrimidin-2-yl) methyl) phenyl) substitued amide derivatives were synthesized using 2-(2-nitrophenyl) acetonitrile and 4,6-dimethoxy-2-(methylsulfonyl) pyrimidine as starting materials by condensation reaction,reduction reaction and acylation reaction,respectively. The structures of all synthesized compounds were determined by 1H NMR,MS and elemental analysis techniques. As-synthesized compounds did not show herbicidal activities at 150 g/hm2. The antibacterial activity test indicated that some of them exhibited certain inhibitory activities against Sphaerotheca fuliginea and Rhizoctonia solani, respectively at 200 mg/L. The inhibition rate of compound 4d against Rhizoctonia solani was 72.3% at 200 mg/L.
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Key words:
- pyrimidinylsalicylic acid
- / dimethoxypyrimidine
- / amide
- / synthesis
- / biological activities
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