The Intercalative Binding Between Rivanol and DNA

Wen You LI Jin Gou XU Xiang Qun GUO Qing Zhi ZHU Yi Bing ZHAO

引用本文: Wen You LI,  Jin Gou XU,  Xiang Qun GUO,  Qing Zhi ZHU,  Yi Bing ZHAO. The Intercalative Binding Between Rivanol and DNA[J]. Chinese Chemical Letters, 1997, 8(4): 309-312. shu
Citation:  Wen You LI,  Jin Gou XU,  Xiang Qun GUO,  Qing Zhi ZHU,  Yi Bing ZHAO. The Intercalative Binding Between Rivanol and DNA[J]. Chinese Chemical Letters, 1997, 8(4): 309-312. shu

The Intercalative Binding Between Rivanol and DNA

  • 基金项目:

    This study was supported by the National Natural Science Foundation of China.

摘要: Rivanol(RVN) binds to the double helical DNA with a high affinity.Strong hypochromism and appreciable red shifts in the absorption spectra can be observed when RVN binds to CT DNA.The results of absorption spectra,KI quenching studies,fluorescence polarization measurements,competitive binding studies,and thermal denaturation experiments suggested that the interaction between RVN and DNA be intercalative.

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  • 收稿日期:  1996-11-08
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