Synthesis of both epimeric triacid ananlogs of kainic acid

Hai Ling Hao Pi Sun Guang Xing Wang Kyoji Fruta Masaaki Suzuki

引用本文: Hai Ling Hao,  Pi Sun,  Guang Xing Wang,  Kyoji Fruta,  Masaaki Suzuki. Synthesis of both epimeric triacid ananlogs of kainic acid[J]. Chinese Chemical Letters, 2008, 19(3): 269-272. doi: 10.1016/j.cclet.2008.01.003 shu
Citation:  Hai Ling Hao,  Pi Sun,  Guang Xing Wang,  Kyoji Fruta,  Masaaki Suzuki. Synthesis of both epimeric triacid ananlogs of kainic acid[J]. Chinese Chemical Letters, 2008, 19(3): 269-272. doi: 10.1016/j.cclet.2008.01.003 shu

Synthesis of both epimeric triacid ananlogs of kainic acid

  • 基金项目:

    This work was supported in part by a Grant-in-Aid for Creative Scientific Research " In vivo Molecular Science for Discovery of New Biofunctions and Pharmaceutical Drugs" (No. 13NP0401), from the Ministry of Education, Culture, Sports, Science and Technology, Japan. G.X.W. thanks the JSPS postdoctoral fellowship for Foreign Researchers.

摘要: A practical and cheap method for synthesis of C-4 carboxylic acid substituted kainic acid analogue 5 and its epimer 6 from trans-4-hydroxyproline is described. Using this method, more interesting intermediates and analogues could be obtained easily.

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  • 收稿日期:  2007-09-18
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