引用本文:
Xue Dan Wu, Dong Zhi Liu, Ai Jun Li, Xue Qin Zhou. Arylpiperazine derivatives of diphenylsulfide: Synthesis and evaluation for dual 5-HT1A/SSRI activities[J]. Chinese Chemical Letters,
2008, 19(3): 291-294.
doi:
10.1016/j.cclet.2008.01.015
Citation: Xue Dan Wu, Dong Zhi Liu, Ai Jun Li, Xue Qin Zhou. Arylpiperazine derivatives of diphenylsulfide: Synthesis and evaluation for dual 5-HT1A/SSRI activities[J]. Chinese Chemical Letters, 2008, 19(3): 291-294. doi: 10.1016/j.cclet.2008.01.015
Citation: Xue Dan Wu, Dong Zhi Liu, Ai Jun Li, Xue Qin Zhou. Arylpiperazine derivatives of diphenylsulfide: Synthesis and evaluation for dual 5-HT1A/SSRI activities[J]. Chinese Chemical Letters, 2008, 19(3): 291-294. doi: 10.1016/j.cclet.2008.01.015
Arylpiperazine derivatives of diphenylsulfide: Synthesis and evaluation for dual 5-HT1A/SSRI activities
摘要:
The design, synthesis and biological evaluation of a novel series of arylpiperazine derivatives of diphenylsulfide with dual 5-HT1A/SSRI activities are reported. The target compounds exhibit low to moderate 5-HT transporter affinity and moderate to high 5-HT1A affinity. Compound 13a shows moderate dual activities and is a promising lead compound for further structure-activity relationships studies.
English
Arylpiperazine derivatives of diphenylsulfide: Synthesis and evaluation for dual 5-HT1A/SSRI activities
Abstract:
The design, synthesis and biological evaluation of a novel series of arylpiperazine derivatives of diphenylsulfide with dual 5-HT1A/SSRI activities are reported. The target compounds exhibit low to moderate 5-HT transporter affinity and moderate to high 5-HT1A affinity. Compound 13a shows moderate dual activities and is a promising lead compound for further structure-activity relationships studies.
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Key words:
- Antidepressants
- / 5-HT1A/SSRI
- / Arylpiperazines
- / 5-HT1A receptor
- / Diphenylsulfide
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