引用本文:
Wei DENG, Ye Feng WANG, Chen ZHANG, Lei LIU, Qing Xiang GUO. CuI/Proline-catalyzed N-Arylation of Nitrogen Heterocycles[J]. Chinese Chemical Letters,
2006, 17(3): 313-316.
Citation: Wei DENG, Ye Feng WANG, Chen ZHANG, Lei LIU, Qing Xiang GUO. CuI/Proline-catalyzed N-Arylation of Nitrogen Heterocycles[J]. Chinese Chemical Letters, 2006, 17(3): 313-316.
Citation: Wei DENG, Ye Feng WANG, Chen ZHANG, Lei LIU, Qing Xiang GUO. CuI/Proline-catalyzed N-Arylation of Nitrogen Heterocycles[J]. Chinese Chemical Letters, 2006, 17(3): 313-316.
CuI/Proline-catalyzed N-Arylation of Nitrogen Heterocycles
摘要:
Ma's CuI/proline procedure for the catalytic cross coupling between nitrogen heterocycles and aryl halides was markedly improved. The key finding was that K3PO4 was a much better base than K2CO3 for the reaction. With this new reaction condition the cross coupling with aryl iodides could be accomplished in 1, 4-dioxane instead of DMSO. This reactin also could be carried out in DMF. Furthermore, the coupling yields under the new conditions are usually higher than in Ma's original methods.
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关键词:
- Cross coupling reaction
- / CuI
- / N-arylation
- / nitrogen heterocycle
- / proline
English
CuI/Proline-catalyzed N-Arylation of Nitrogen Heterocycles
Abstract:
Ma's CuI/proline procedure for the catalytic cross coupling between nitrogen heterocycles and aryl halides was markedly improved. The key finding was that K3PO4 was a much better base than K2CO3 for the reaction. With this new reaction condition the cross coupling with aryl iodides could be accomplished in 1, 4-dioxane instead of DMSO. This reactin also could be carried out in DMF. Furthermore, the coupling yields under the new conditions are usually higher than in Ma's original methods.
-
Key words:
- Cross coupling reaction
- / CuI
- / N-arylation
- / nitrogen heterocycle
- / proline
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