引用本文:
Mu YUAN, Yu Guo ZHONG, Qi Jie PANG. Synthesis and Anticonvulsant Activity of γ-Aminobutyric Acid Derivatives[J]. Chinese Chemical Letters,
1998, 9(4): 369-371.
Citation: Mu YUAN, Yu Guo ZHONG, Qi Jie PANG. Synthesis and Anticonvulsant Activity of γ-Aminobutyric Acid Derivatives[J]. Chinese Chemical Letters, 1998, 9(4): 369-371.
Citation: Mu YUAN, Yu Guo ZHONG, Qi Jie PANG. Synthesis and Anticonvulsant Activity of γ-Aminobutyric Acid Derivatives[J]. Chinese Chemical Letters, 1998, 9(4): 369-371.
Synthesis and Anticonvulsant Activity of γ-Aminobutyric Acid Derivatives
摘要:
Under physiological conditions, γ-aminobutyric acid poorly crosses the blood-brain barrier. It is likely that a non-toxic derivative of γ-aminobutyric acid which enters the brain easily will have useful anticonvulsant activity. 16 derivatives of γ-aminobutyric acid with an imine link to a lipophilic carrier were prepared and tested for anticonvulsant activity; six compounds show anticonvulsant activity.
English
Synthesis and Anticonvulsant Activity of γ-Aminobutyric Acid Derivatives
Abstract:
Under physiological conditions, γ-aminobutyric acid poorly crosses the blood-brain barrier. It is likely that a non-toxic derivative of γ-aminobutyric acid which enters the brain easily will have useful anticonvulsant activity. 16 derivatives of γ-aminobutyric acid with an imine link to a lipophilic carrier were prepared and tested for anticonvulsant activity; six compounds show anticonvulsant activity.
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Key words:
- γ-aminobutyric acid
- / synthesis
- / anticonvulsant activity
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