引用本文:
Hai Shan Jin, Li Ming Zhao. A contribution to the study of the modified Marschalk reaction:Hydroxymethylation of 6,8-O-dimethyl emodin[J]. Chinese Chemical Letters,
2010, 21(5): 568-571.
doi:
10.1016/j.cclet.2010.01.013
Citation: Hai Shan Jin, Li Ming Zhao. A contribution to the study of the modified Marschalk reaction:Hydroxymethylation of 6,8-O-dimethyl emodin[J]. Chinese Chemical Letters, 2010, 21(5): 568-571. doi: 10.1016/j.cclet.2010.01.013
Citation: Hai Shan Jin, Li Ming Zhao. A contribution to the study of the modified Marschalk reaction:Hydroxymethylation of 6,8-O-dimethyl emodin[J]. Chinese Chemical Letters, 2010, 21(5): 568-571. doi: 10.1016/j.cclet.2010.01.013
A contribution to the study of the modified Marschalk reaction:Hydroxymethylation of 6,8-O-dimethyl emodin
摘要:
Hydroxymethylation of 6,8-O-dimethyl emodin was easily achieved in good yields by the modified Marschalk reaction. The influence of the amount of solvent, base and formaldehyde toward the hydroxymethylation was discussed. The results showed that a relatively dilute reaction solution facilitated the generation of the desired 2-hydromethyl product, while the thick reaction solution benefited the generation of the methylated quinizarins.
English
A contribution to the study of the modified Marschalk reaction:Hydroxymethylation of 6,8-O-dimethyl emodin
Abstract:
Hydroxymethylation of 6,8-O-dimethyl emodin was easily achieved in good yields by the modified Marschalk reaction. The influence of the amount of solvent, base and formaldehyde toward the hydroxymethylation was discussed. The results showed that a relatively dilute reaction solution facilitated the generation of the desired 2-hydromethyl product, while the thick reaction solution benefited the generation of the methylated quinizarins.
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Key words:
- Marschalk reaction
- / Hydroxymethylation
- / Emodin
- / Antitumor activity
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