引用本文:
Guang Yu XU, Yi ZHOU, Man Cai XU. A Convenient Synthesis of Antibacterial Linezolid from (S)-Glyceraldehyde Acetonide[J]. Chinese Chemical Letters,
2006, 17(3): 302-304.
Citation: Guang Yu XU, Yi ZHOU, Man Cai XU. A Convenient Synthesis of Antibacterial Linezolid from (S)-Glyceraldehyde Acetonide[J]. Chinese Chemical Letters, 2006, 17(3): 302-304.
Citation: Guang Yu XU, Yi ZHOU, Man Cai XU. A Convenient Synthesis of Antibacterial Linezolid from (S)-Glyceraldehyde Acetonide[J]. Chinese Chemical Letters, 2006, 17(3): 302-304.
A Convenient Synthesis of Antibacterial Linezolid from (S)-Glyceraldehyde Acetonide
摘要:
A convenient synthesis of oxazolidinone antibacterial linezolid from readily available L-ascorbic acid is described. The key steps include reductive amination of arylamine and (S)-glyceraldehyde acetonide in the presence of NaBH4 and 4Ǻ sieve, followed by hydrolysis and regioselective cyclization.
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关键词:
- Linezolid
- / antibacterial
- / synthesis
- / ascorbic acid
English
A Convenient Synthesis of Antibacterial Linezolid from (S)-Glyceraldehyde Acetonide
Abstract:
A convenient synthesis of oxazolidinone antibacterial linezolid from readily available L-ascorbic acid is described. The key steps include reductive amination of arylamine and (S)-glyceraldehyde acetonide in the presence of NaBH4 and 4Ǻ sieve, followed by hydrolysis and regioselective cyclization.
-
Key words:
- Linezolid
- / antibacterial
- / synthesis
- / ascorbic acid
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