引用本文:
Li Jun Yan, Quan Zhong Liu, Xue Lian Wang. Novel chiral thioureas for highly enantioselective Michael reactions of malonates to nitroalkenes[J]. Chinese Chemical Letters,
2009, 20(3): 310-313.
doi:
10.1016/j.cclet.2008.11.021
Citation: Li Jun Yan, Quan Zhong Liu, Xue Lian Wang. Novel chiral thioureas for highly enantioselective Michael reactions of malonates to nitroalkenes[J]. Chinese Chemical Letters, 2009, 20(3): 310-313. doi: 10.1016/j.cclet.2008.11.021
Citation: Li Jun Yan, Quan Zhong Liu, Xue Lian Wang. Novel chiral thioureas for highly enantioselective Michael reactions of malonates to nitroalkenes[J]. Chinese Chemical Letters, 2009, 20(3): 310-313. doi: 10.1016/j.cclet.2008.11.021
Novel chiral thioureas for highly enantioselective Michael reactions of malonates to nitroalkenes
摘要:
Highly efficient Michael addition reactions of malonates to nitroalkenes catalyzed by novel chiral thioureas derived from optically pure BINOL and amino acids are reported. Various trans-nitroalkenes reacted with malonates affording the desired products in up to 95% yield with excellent enantioselectivities (up to 97% ee).
English
Novel chiral thioureas for highly enantioselective Michael reactions of malonates to nitroalkenes
Abstract:
Highly efficient Michael addition reactions of malonates to nitroalkenes catalyzed by novel chiral thioureas derived from optically pure BINOL and amino acids are reported. Various trans-nitroalkenes reacted with malonates affording the desired products in up to 95% yield with excellent enantioselectivities (up to 97% ee).
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Key words:
- Michael addition
- / Thiourea
- / Enantioselectivities
- / Nitroalkene and malonate
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