English

• Medium-sized molecular ring structures, particularly 8-membered benzo[b]azocines, are prominent structural motifs that are found in many natural products and bioactive molecules (Fig. 1) [1-8]. These ring structures tend to exhibit unique biological activities as analgesic or sedative agents that affect the central nervous system. However, synthesizing 8-membered benzo[b]azocines is difficult, owing to several inherently unfavorable enthalpic and entropic barriers associated with the transition states leading to medium-sized rings [9-14]. In recent decades, steady progress has been made in the preparation of medium-sized benzo[b]azocine frameworks, with cycloaddition [15-25] and ring closing metathesis [26-28], representing the most straightforward routes to these 8-membered N-heterocycles. Nevertheless, most available synthetic procedures require noble transition metal catalysts or unstable starting materials. Therefore, novel strategies should be developed for the facile preparation of medium-sized benzo[b]azocines.

  Figure 1

  

  Figure 1.  Selected azocinone moieties found in bioactive molecules and natural products.

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  Organoselenium compounds, especially selenium-containing N-heterocycles, are important molecules owing to their roles in medicine and materials science [29-36]. Therefore, significant research efforts have been devoted to exploring practical methods for synthesizing selenium-functionalized heterocycles [37]. In particular, selenium-centered radical-initiated tandem cyclization at unsaturated bonds represents a valuable strategy for preparing selenium-containing N-heterocycles [38-45]. Recently, electrochemical seleno-cyclization across unsaturated bonds [46-50] has demonstrated utility as an environmental-friendly strategy [51,52] for constructing such heterocycles using only electrons to provide the reaction driving force. Moreover, the electrical potential can be precisely controlled during the required electrochemical process, which enables acute manipulation of the chemoselectivity and reactivity [53-56]. Building upon our group's work related to nitrogen heterocyclic chemistry [57-61], herein we designed a diene system comprising N-(but-3-en-1-yl)−2-vinylanilines and explored electrochemical selenium-centered radical-initiated tandem cyclization. This approach involved unique chemo- and regioselective addition with 8-endo cyclization to obtain a series of 8-membered benzo[b]azocine derivatives. Previous reports have described energetically favorable seleno-radical-based addition cyclizations to selenium-containing 5- or 6-membered N-heterocycles (Scheme 1a) or ionic cycloaddition and ring closing metathesis strategies. However, to our knowledge, this article presents the first successful example of radical-triggered ordered addition involving an 8-endo cyclization reaction to prepare medium-sized seleno-benzo[b]azepines (Scheme 1b).

  Scheme 1

  

  Scheme 1.  RSe^•-triggered addition cyclization to obtain seleno-heterocycles.

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  To achieve this goal, critical challenges that originate from the multiple substrate reactive sites and the energetics of cyclization need to be overcome. For example, the diphenylethylene fragment in diene molecules is a powerful radical inhibitor with strong radical trapping capabilities. Therefore, the seleno-radicals generated in situ are likely to be trapped, thereby terminating the reaction (challenge ⅰ). Additionally, in terms of thermodynamics, the secondary carbon radical intermediate might be inclined toward 6-endo cyclization to afford an undesirable quinoline scaffold (challenge ⅱ). Finally, considering the two alkenyl groups (activated and unactivated) in the diene system, directing the chemoselective addition of seleno-groups to both double bonds is difficult (challenge ⅲ).

  To determine the optimal reaction conditions for the proposed chemo- and regioselective seleno-cyclization, we first carried out the reaction using N-(but-3-en-1-yl)−4-methyl-N-(2-(1-phenylvinyl)phenyl)benzenesulfonamide 1a and diphenyl diselenide 2a as model substrates. As shown in Table 1, Pt(+)/Pt(−) were selected as the anode and cathode, respectively, with ⁿBu₄NBF₄ as the supporting electrolyte. The test reaction was performed in 1, 2-dichloroethane (DCE) at room temperature under a constant current of 2 mA in an undivided three-necked flask for 3 h, and under these conditions, the target 3a could be isolated in 33% yield (entry 1). We then tested other common electrolytes, including ⁿBu₄NI, ⁿBu₄NPF₆, and ⁿBu₄NClO₄. The results indicated that ⁿBu₄NPF₆ exhibited the most positive effect, leading to an isolated yield of 3a of 47% (entry 3), whereas reactions with ⁿBu₄NI and ⁿBu₄NClO₄ did not proceed efficiently (entries 2 and 4, respectively). Solvent screening revealed that N, N-dimethylformamide (DMF), tetrahydrofuran (THF), and methanol (MeOH) were not ideal for this transformation (entries 5–7), while dichloromethane (DCM) gave a satisfactory yield of 3a up to 60% (entry 8). The impacts of the electrode materials were also explored; however, lower reaction yields were obtained when the Pt(+)/Pt(−) electrodes were replaced with C(+)/C(−) or C(+)/Pt(−) (entries 9 and 10).

  Table 1

  

  Table 1.  Optimization of reaction conditions.^a

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  Moreover, the yield was not improved appreciably when changing the constant current to 4 mA or appropriately modifying the amount of electrolyte (entries 11−13). A control experiment also confirmed that the desired product 3a was not generated without electricity (entry 14).

  Next, we used the optimized reaction conditions to examine the substrate scope for the seleno-cyclization of 8-membered seleno-benzo[b]azocines (Scheme 2). Substrates with electron-withdrawing (3-F, 4-F, 4-Cl, 4-Br, 5-Br) or electron-donating groups (4-Me, 4-OMe, 4-p-CNPh, 5-Me, 5-OMe) on the phenyl ring of the aniline moiety were compatible with this reaction; the transformation proceeded smoothly to afford the corresponding 8-membered seleno-benzo[b]azocines 3b−3k in 51%−72% yields. Next, we investigated how substituents on the alkene-tethered phenyl ring influenced the reaction. Substrates bearing o-Me, p-Cl, p-Br, and p-Me groups on the phenyl were all compatible with this conversion, giving the corresponding products 3l−3q in 47%−62% yields. When the N-Ts moiety was replaced with NH, the seleno-cyclization did not occur.

  Scheme 2

  

  Scheme 2.  Diene substrate scope. Reaction conditions: 1 (0.2 mmol), 2a (0.2 mmol), supporting electrolyte ⁿBu₄NPF₆ (0.4 mmol), 2 mA constant current, DCM solvent (6 mL), room temperature, 12 h, isolated yields are reported.

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  We further explored the diselenide substrate scope of the seleno-cyclization reaction. As shown in Scheme 3, diselenides bearing electron-donating (–Me, –OMe, –Ph, –^tBu) and electron-withdrawing substituents (–Cl, –Br) at various positions on the phenyl ring were all compatible with the reaction, and the corresponding seleno-cyclization products 3r−3ab were isolated in moderate to high yields (41%−83%). Steric effects did not appear to impact the seleno-cyclization process because diselenides with o-, m-, and p-Me groups on the phenyl ring proceeded smoothly, and no appreciable yield disparity was observed (3r, 3t, and 3w). Furthermore, 1, 2-di(naphthalen-2-yl)diselane and multi-substituted 1, 2-bis(3, 5-dimethylphenyl)diselane and 1, 2-dimesityldiselane were also suitable substrates for this transformation; the corresponding products 3ac, 3ad, and 3ae were obtained in 46%, 61%, and 52% yields, respectively. Diselenides with –OH, –NH₂, and thiophene substituents were incompatible with this electrochemically-driven transformation.

  Scheme 3

  

  Scheme 3.  Diselenide substrate scope. Reaction conditions: 1a (0.2 mmol), 2 (0.2 mmol), supporting electrolyte ⁿBu₄NPF₆ (0.4 mmol), 2 mA constant current, DCM solvent (6 mL), room temperature, 12 h, isolated yields are reported.

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  Importantly, the facile conversion of seleno-groups to other functional groups renders selenation reactions indispensable. Treating seleno-benzo[b]azepine 3a with m-chloroperbenzoic acid (m-CPBA) or H₂O₂ generated the desired deselenation product 4 via oxidation-elimination under mild conditions. This result indicated the potential for further synthetic transformations, such as hydroxylation, oxidation, difunctionalization, and epoxidation (Scheme 4) [62-65].

  Scheme 4

  

  Scheme 4.  Deselenation investigations.

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  Control experiments were performed to gain mechanistic insights regarding this seleno-cyclization reaction (details in Supporting information). First, when a stoichiometric amount of a radical scavenger, e.g., 2, 2, 6, 6-tetramethyl-1-piperidinyloxy (TEMPO, 2.0 equiv.) or 2, 6-di-tert-butyl-4-methylphenol (BHT, 2.0 equiv.) was added into the standard reaction system, the seleno-cyclization was remarkably inhibited, such that substrate 1a was recovered (Schemes 5a and b). When stilbene (2.0 equiv.) was added, only 17% of 3a could be isolated, and the radical-trapping product 5 was detected via high resolution mass spectrometry (HRMS) analysis (Scheme 5c). These results suggest that the transformation may proceed through a radical-type mechanism involving a seleno-centered radical. We also conducted a control experiment in a divided cell, and product 3a was detected following anodic oxidation (isolated yield = 43%; Scheme 5d), indicating that the reaction could be completed directly at the anode.

  Scheme 5

  

  Scheme 5.  Control experiments.

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  Cyclic voltammetry (CV) experiments were also performed using 1a and 2a (Fig. 2). The oxidation peak of 1a appeared at 2.00 V, which was similar to that of 2a (1.98 V), consistent with Lei and co-workers' characterization of 2a [66].

  Figure 2

  

  Figure 2.  Cyclic voltammetry results.

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  On the basis of these experimental results, we proposed a plausible reaction mechanism for the photo-induced 8-endo seleno-cyclization process (Scheme 6). First, anodic oxidation of (PhSe)₂ 2a generates seleno-radical and seleno-cation intermediates. Steric effects most likely render the seleno-radical more inclined to react with the double bond of the butenyl group to form the favored radical intermediate A, which then undergoes an intramolecular 8-endo cyclization to deliver the radical intermediate B. Importantly, the competitive intramolecular 6-endo cyclization to a thermodynamically favorable quinoline scaffold (Scheme 1b, challenge ⅱ) was not observed during the transformation. Subsequently, radical intermediate B rapidly undergoes one-electron oxidation at the anode and deprotonation to yield the desired 8-membered benzo[b]azocine 3a. Meanwhile, the electrochemical reduction of the DCM solvent or proton occurs at the cathode to balance the overall charge state of the system.

  Scheme 6

  

  Scheme 6.  Proposed mechanism.

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  Detailed density functional theory (DFT) calculations were performed using the Gaussian 16 package to gain additional mechanistic insights and to determine the origin of the observed chemoselectivity (Fig. 3, additional details in Supporting information). The DFT calculations first probed the reaction between the in situ generated seleno-radical and substrate 1a. As shown in Fig. 3a, four potential transition states for the radical addition process could be located depending on the reaction site (i.e., the double bonds in the butenyl group and diphenylethylene). Radical addition at the terminal carbons of the butenyl double bond (via TS1–2) and the diphenylethylene (via TS1–2a) faced lower reaction barriers compared with TS1–2b and TS1–2c. Energy decomposition analysis (Fig. 3b) for TS1–2 and TS1–2b indicated that the high free energy barrier associated with TS1–2b could be ascribed to the large geometric distortion from the planer sp² carbon center to the tetrahedral pseudo-sp³ carbon center (dihedral angels in TS1–2b and TS1–2 measured as 149.6° and 153.7°, respectively). Similar results were obtained from the energy decomposition analysis of TS1–2a and TS1–2c (Fig. 3c), where the planer carbon center was distorted to 138.4° in TS1–2c. We also found that Int2 could isomerize to Int3 or Int3'; these two are primed for the subsequent intramolecular cyclization process. These DFT calculations indicated that the free energy barrier required for 8-endo cyclization via TS3–4 was 10.7 kcal/mol, which is 3.5 kcal/mol more favorable than that for the 6-endo cyclization via TS3–4′. In addition, the 8-endo cyclization intermediate Int4 is thermodynamically more stable than Int4' by 18.7 kcal/mol. The DFT calculations also revealed that the cyclization of intermediate Int5 to Int6 is kinetically and thermodynamically unfavorable. Overall, the computational results support the 8-endo cyclization pathway, through which Int4 can be further oxidized and deprotonated to yield the desired 8-membered benzo[b]azocine 3a.

  Figure 3

  

  Figure 3.  The relative free energy profiles for the mechanism.

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  In conclusion, we developed a novel method for the electrochemically-driven chemoselective seleno-cyclization of dienes to prepare medium-sized benzo[b]azocines. After compensating for the inherently unfavorable enthalpic and entropic factors and variable chemoselectivity, we obtained 31 structurally diverse seleno-benzo[b]azepines in moderate to high yields at room temperature. The facile deselenation of the seleno-cyclization product to afford new functionalized dienes is an additional valuable feature of this reaction. The inhibition experiments, divided-cell experiments, and CV results were used to propose a plausible radical-based mechanism. DFT calculations further rationalized the rate-determining step and chemoselectivity observed in this transformation.

  Declaration of competing interest

  The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

  Acknowledgments

  This work was supported by the National Natural Science Foundation of China (No. 21801007) and Qingchuang Technology Support Program of University in Shandong Province (No. 2021KJ066). S.-F. Ni acknowledges funding from the STU Scientific Research Foundation for Talents (No. NTF20022).

  Supplementary materials

  Supplementary material associated with this article can be found, in the online version, at doi:10.1016/j.cclet.2023.109058.

  
  
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• 

  Figure 1  Selected azocinone moieties found in bioactive molecules and natural products.

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  Scheme 1  RSe^•-triggered addition cyclization to obtain seleno-heterocycles.

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  Scheme 2  Diene substrate scope. Reaction conditions: 1 (0.2 mmol), 2a (0.2 mmol), supporting electrolyte ⁿBu₄NPF₆ (0.4 mmol), 2 mA constant current, DCM solvent (6 mL), room temperature, 12 h, isolated yields are reported.

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  Scheme 3  Diselenide substrate scope. Reaction conditions: 1a (0.2 mmol), 2 (0.2 mmol), supporting electrolyte ⁿBu₄NPF₆ (0.4 mmol), 2 mA constant current, DCM solvent (6 mL), room temperature, 12 h, isolated yields are reported.

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  Scheme 4  Deselenation investigations.

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  Scheme 5  Control experiments.

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  Figure 2  Cyclic voltammetry results.

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  Scheme 6  Proposed mechanism.

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  Figure 3  The relative free energy profiles for the mechanism.

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  Table 1.  Optimization of reaction conditions.^a

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•