引用本文:
Li Qiang Fu, Xin Sheng Guo, Xin Liu, Hui Li He, Yu Lin Wang, Yu She Yang. Synthesis and antibacterial activity of C-2 (S)-substituted pleuromutilin derivatives[J]. Chinese Chemical Letters,
2010, 21(5): 507-510.
doi:
10.1016/j.cclet.2010.01.001
Citation: Li Qiang Fu, Xin Sheng Guo, Xin Liu, Hui Li He, Yu Lin Wang, Yu She Yang. Synthesis and antibacterial activity of C-2 (S)-substituted pleuromutilin derivatives[J]. Chinese Chemical Letters, 2010, 21(5): 507-510. doi: 10.1016/j.cclet.2010.01.001
Citation: Li Qiang Fu, Xin Sheng Guo, Xin Liu, Hui Li He, Yu Lin Wang, Yu She Yang. Synthesis and antibacterial activity of C-2 (S)-substituted pleuromutilin derivatives[J]. Chinese Chemical Letters, 2010, 21(5): 507-510. doi: 10.1016/j.cclet.2010.01.001
Synthesis and antibacterial activity of C-2 (S)-substituted pleuromutilin derivatives
摘要:
In order to probe the effect of C-2 (S)-substituted groups in the antibacterial activity, a series of novel C-2 (S)-substituted pleuromutilin analogues of SB-225586 were synthesized and evaluated for their in vitro antibacterial activity. The results of antibacterial activities indicated that C-2 (S)-substituted pleuromutilin derivatives retained appreciable antibacterial activity, and the 2-fluorination compounds 6a and 6b are more potent than the corresponding 2-hydroxylation analogues 7a and 7b.
English
Synthesis and antibacterial activity of C-2 (S)-substituted pleuromutilin derivatives
Abstract:
In order to probe the effect of C-2 (S)-substituted groups in the antibacterial activity, a series of novel C-2 (S)-substituted pleuromutilin analogues of SB-225586 were synthesized and evaluated for their in vitro antibacterial activity. The results of antibacterial activities indicated that C-2 (S)-substituted pleuromutilin derivatives retained appreciable antibacterial activity, and the 2-fluorination compounds 6a and 6b are more potent than the corresponding 2-hydroxylation analogues 7a and 7b.
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Key words:
- Synthesis
- / Pleuromutilin
- / C-2 (S)-substituted
- / Antimicrobial activity
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