引用本文:
Juan Huang, Jian Wei Wang, Tao Gong, Zhi Rong Zhang. Synthesis and characterization of insulin-5-Fu conjugate,enabling insulin as multi-drug carder via dendritic approach[J]. Chinese Chemical Letters,
2007, 18(3): 247-250.
doi:
10.1016/j.cclet.2006.12.026
Citation: Juan Huang, Jian Wei Wang, Tao Gong, Zhi Rong Zhang. Synthesis and characterization of insulin-5-Fu conjugate,enabling insulin as multi-drug carder via dendritic approach[J]. Chinese Chemical Letters, 2007, 18(3): 247-250. doi: 10.1016/j.cclet.2006.12.026
Citation: Juan Huang, Jian Wei Wang, Tao Gong, Zhi Rong Zhang. Synthesis and characterization of insulin-5-Fu conjugate,enabling insulin as multi-drug carder via dendritic approach[J]. Chinese Chemical Letters, 2007, 18(3): 247-250. doi: 10.1016/j.cclet.2006.12.026
Synthesis and characterization of insulin-5-Fu conjugate,enabling insulin as multi-drug carder via dendritic approach
摘要:
To enable insulin as multi-drug carrier, we designed and synthesized dendritic linker molecule bearing three 5-fluorouracil residues at the branch ends. The new conjugate showed excellent water solubility. The stabilities under different conditions were investigated. The results showed that the conjugate was a potential prodrug to release free 5-Fu.
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关键词:
- Insulin
- / 5-Fluorouracil
- / Prodrug
- / Characterization
- / Stability
English
Synthesis and characterization of insulin-5-Fu conjugate,enabling insulin as multi-drug carder via dendritic approach
Abstract:
To enable insulin as multi-drug carrier, we designed and synthesized dendritic linker molecule bearing three 5-fluorouracil residues at the branch ends. The new conjugate showed excellent water solubility. The stabilities under different conditions were investigated. The results showed that the conjugate was a potential prodrug to release free 5-Fu.
-
Key words:
- Insulin
- / 5-Fluorouracil
- / Prodrug
- / Characterization
- / Stability
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