Fe3O4/MnO2掺杂石墨烯基分子印迹杂化材料用于水环境中17β-雌二醇的电化学传感检测

引用本文: 李颖, 徐文凯, 李苹, 朱小雪, 黄艳凤, 张纪梅. Fe₃O₄/MnO₂掺杂石墨烯基分子印迹杂化材料用于水环境中17β-雌二醇的电化学传感检测[J]. 分析化学, 2018, 46(7): 1047-1054. doi: 10.11895/j.issn.0253-3820.171195 shu

Citation: LI Ying, XU Wen-Kai, LI Ping, ZHU Xiao-Xue, HUANG Yan-Feng, ZHANG Ji-Mei. Molecularly Imprinted Polymer Electrochemical Sensor Based on Fe₃O₄/MnO₂ Doped Graphene Composites for Determination of 17β-Estradiol in Aquatic Environment[J]. Chinese Journal of Analytical Chemistry, 2018, 46(7): 1047-1054. doi: 10.11895/j.issn.0253-3820.171195 shu

Fe₃O₄/MnO₂掺杂石墨烯基分子印迹杂化材料用于水环境中17β-雌二醇的电化学传感检测

李颖 ^1,2, ,
徐文凯 ^1, ,
李苹 ^1, ,
朱小雪 ^1, ,
黄艳凤 ^1, ,
张纪梅 ^1,

1.
天津工业大学环境与化学工程学院, 中空纤维膜材料与膜过程国家重点实验室, 天津 300387;
2.
哈尔滨工业大学材料科学与工程学院, 哈尔滨 150001
基金项目:
本文系国家自然科学基金项目（Nos.21106101，21475095）、天津市自然科学基金项目（No.13JCQNJC06300）和中国博士后基金项目（No.2013M540281）资助

摘要: 采用可逆加成-断裂链转移（Reversible addition fragmentation chain transfer，RAFT）分子印迹技术，以内分泌干扰物17β-雌二醇（17β-estradiol，17β-E₂）作为模板分子，以甲基丙烯酸（Methacrylic acid，MAA）为功能单体，二乙烯基苯（Divinyl benzene，DVB）为交联剂，Fe₃O₄/MnO₂掺杂的石墨烯（RGO）为载体，成功制备了Fe₃O₄/MnO₂掺杂石墨烯基分子印迹杂化材料（Fe₃O₄/MnO₂-MIP@RGO），构建了基于Fe₃O₄/MnO₂-MIP@RGO修饰电极的分子印迹电化学传感器。研究结果表明，Fe₃O₄/MnO₂-MIP@RGO修饰电极对17β-E₂的线性响应范围为4.0 nmol/L~0.8 μmol/L（R=0.9852），检出限为47.2 pmol/L（3σ），相对标准偏差（RSD）为2.1%~2.5%。本研究为水环境中痕量17β-E₂的特异性识别检测提供了一种简单、高效、经济的分析方法。

关键词:

English

Molecularly Imprinted Polymer Electrochemical Sensor Based on Fe₃O₄/MnO₂ Doped Graphene Composites for Determination of 17β-Estradiol in Aquatic Environment

1.
School of Environmental and Chemical Engineering, Tianjin Polytechnic University, State Key Laboratory of Hollow Fiber Membrane Materials and Membrane Process, Tianjin 300387, China;
2.
School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, China
Received Date: 24 August 2017
Revised Date: 30 March 2018
Fund Project:
This work was supported by the National Natural Science Foundation of China (Nos. 21106101, 21475095), the Natural Science Foundation of Tianjin, China (No.13JCQNJC06300) and Postdoctoral Foundation of China (No. 2013M540281).

Abstract: In this paper, Fe₃O₄/MnO₂ doped graphene molecularly imprinted hybrid material (Fe₃O₄/MnO₂-MIP@RGO) was successfully synthesized via reversible addition fragmentation chain transfer (RAFT) molecularly imprinting technique by using methacrylic acid as functional monomer, divinylbenzene as cross-linker, Fe₃O₄/MnO₂@RGO as carrier, and 17β-estradiol (17β-E2) as template molecule. A novel molecularly imprinting electrochemical sensor by using Fe₃O₄/MnO₂-MIP@RGO modified electrode was constructed to specifically detect trace 17β-E2 in water. The experimental results showed that the Fe₃O₄/MnO₂-MIP@RGO electrochemical sensor exhibited rapid and linear current response to 17β-E2 in water samples with a linear range of 4 nmol/L to 0.8 μmol/L (R=0.9852), the detection limit was 47.2 pmol/L (3σ) and the relative standard deviation (RSD) was from 2.1% to 2.5%. This study provides a simple and efficient, economical and reliable method for the monitoring of 17β-estradiol in the complex water environment.

Key words:

Reversible addition fragmentation chain transfer molecularly imprinting technique
/ Reduced graphene oxide
/ Electrochemical sensor
/ Metal oxide
/ 17β-Estradiol

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沈阳化工大学材料科学与工程学院沈阳 110142

Fe₃O₄/MnO₂掺杂石墨烯基分子印迹杂化材料用于水环境中17β-雌二醇的电化学传感检测

English

Molecularly Imprinted Polymer Electrochemical Sensor Based on Fe₃O₄/MnO₂ Doped Graphene Composites for Determination of 17β-Estradiol in Aquatic Environment

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