引用本文:
Jie YANG, Yu Yang JIANG, Sheng Li CAO, Hua FU, Yu Fen ZHAO. Synthesis of N-Phosphoryl Branched Peptides[J]. Chinese Chemical Letters,
2005, 16(3): 317-320.
Citation: Jie YANG, Yu Yang JIANG, Sheng Li CAO, Hua FU, Yu Fen ZHAO. Synthesis of N-Phosphoryl Branched Peptides[J]. Chinese Chemical Letters, 2005, 16(3): 317-320.
Citation: Jie YANG, Yu Yang JIANG, Sheng Li CAO, Hua FU, Yu Fen ZHAO. Synthesis of N-Phosphoryl Branched Peptides[J]. Chinese Chemical Letters, 2005, 16(3): 317-320.
Synthesis of N-Phosphoryl Branched Peptides
摘要:
H-phosphonates were conveniently prepared by direct transesterification of diphenyl phosphite (DPP) with the corresponding alcohols, without further purification they were reacted with branched peptide methyl ester (L-Leu2-L-LysOMe) through Atherton-Todd method, a series of different substituted alkyloxy (N-phosphoryl-L-Leu)2-L-LysOMe were synthesized, and their structures were confirmed by 31p NMR, ESI-MS, 1H NMR, 13C NMR, IR and elemental analysis.The approach possesses the advantages of easy operation, high yield and inexpensive phosphorylating reagent.
English
Synthesis of N-Phosphoryl Branched Peptides
Abstract:
H-phosphonates were conveniently prepared by direct transesterification of diphenyl phosphite (DPP) with the corresponding alcohols, without further purification they were reacted with branched peptide methyl ester (L-Leu2-L-LysOMe) through Atherton-Todd method, a series of different substituted alkyloxy (N-phosphoryl-L-Leu)2-L-LysOMe were synthesized, and their structures were confirmed by 31p NMR, ESI-MS, 1H NMR, 13C NMR, IR and elemental analysis.The approach possesses the advantages of easy operation, high yield and inexpensive phosphorylating reagent.
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