引用本文:
Zhen Ying Li, Zhao Sheng Liu, Qing Wei Zhang, Hong Quan Duan. Chiral separation by (S)-naproxen imprinted monolithic column with mixed functional monomers[J]. Chinese Chemical Letters,
2007, 18(3): 322-324.
doi:
10.1016/j.cclet.2007.01.037
Citation: Zhen Ying Li, Zhao Sheng Liu, Qing Wei Zhang, Hong Quan Duan. Chiral separation by (S)-naproxen imprinted monolithic column with mixed functional monomers[J]. Chinese Chemical Letters, 2007, 18(3): 322-324. doi: 10.1016/j.cclet.2007.01.037
Citation: Zhen Ying Li, Zhao Sheng Liu, Qing Wei Zhang, Hong Quan Duan. Chiral separation by (S)-naproxen imprinted monolithic column with mixed functional monomers[J]. Chinese Chemical Letters, 2007, 18(3): 322-324. doi: 10.1016/j.cclet.2007.01.037
Chiral separation by (S)-naproxen imprinted monolithic column with mixed functional monomers
摘要:
Molecularly imprinted polymers (MIPs), using (S)-naproxen as template and the combination of butyl methacrylate (BMA) and MAA (1:1 molar ratio) as functional monomers were synthesized by an in situ polymerization reaction. The rendered monolithic column was evaluated in HPLC mode. The result showed that the monolithic MIPs with the combination of two monomers produced better chiral resolution of rac-naproxen (Rs=1.55) and column efficiencies of imprinted molecules (N=2860 plates/m)than that with pure MAA.
English
Chiral separation by (S)-naproxen imprinted monolithic column with mixed functional monomers
Abstract:
Molecularly imprinted polymers (MIPs), using (S)-naproxen as template and the combination of butyl methacrylate (BMA) and MAA (1:1 molar ratio) as functional monomers were synthesized by an in situ polymerization reaction. The rendered monolithic column was evaluated in HPLC mode. The result showed that the monolithic MIPs with the combination of two monomers produced better chiral resolution of rac-naproxen (Rs=1.55) and column efficiencies of imprinted molecules (N=2860 plates/m)than that with pure MAA.
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Key words:
- Molecularly imprinted polymer
- / Monolithic column
- / Naproxen
- / Chiral separation
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