基于信号放大策略的分子印迹-电化学发光抗生素传感器研究进展

引用本文: 肖聪, 廉文静, 姚惠琴, 杨宝华, 刘红云. 基于信号放大策略的分子印迹-电化学发光抗生素传感器研究进展[J]. 分析化学, 2022, 50(2): 173-182. doi: 10.19756/j.issn.0253-3820.210789 shu

Citation: XIAO Cong, LIAN Wen-Jing, YAO Hui-Qin, YANG Bao-Hua, LIU Hong-Yun. Progress of Molecularly Imprinted Polymers-Electrochemiluminescence Antibiotic Sensors Based on Signal Amplification Strategies[J]. Chinese Journal of Analytical Chemistry, 2022, 50(2): 173-182. doi: 10.19756/j.issn.0253-3820.210789 shu

基于信号放大策略的分子印迹-电化学发光抗生素传感器研究进展

肖聪 ^1, ,
廉文静 ^2, ,
姚惠琴 ^3, ,
杨宝华 ^4, ,
刘红云 ^{1,
,}

1.
北京师范大学化学学院, 放射性药物教育部重点实验室, 北京 100875;
2.
天津农学院基础科学学院, 天津 300384;
3.
宁夏医科大学基础医学院, 银川 750004;
4.
首都医科大学燕京医学院, 北京 101300

通讯作者: 刘红云,E-mail:liuhongyun@bnu.edu.cn

基金项目:
宁夏回族自治区重点研发计划项目（No.2018BEG03017）、北京市自然科学基金项目（No.2182027）和天津市教委科研计划项目（No.2020KJ099）资助

摘要: 抗生素残留已成为全球公共卫生最严重的威胁之一，发展高效、快速且简便的抗生素检测方法具有重要意义。分子印迹聚合物(MIP)作为人工合成的化学受体，可以高亲和力选择性识别目标分子，电化学发光(ECL)是一种发展成熟、应用广泛的电分析技术，两者结合的分子印迹-电化学发光法(MIP-ECL)具有选择性高、检出限低、成本低廉等优势，是一种具有巨大发展潜力的抗生素残留检测新技术。本文综述了近年来MIP-ECL技术的发展现状，重点介绍了多种基于信号放大策略的MIP-ECL抗生素传感器，并且对其发展前景与方向进行了展望。

关键词:

English

Progress of Molecularly Imprinted Polymers-Electrochemiluminescence Antibiotic Sensors Based on Signal Amplification Strategies

1.
Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China;
2.
College of Basic Science, Tianjin Agricultural University, Tianjin 300384, China;
3.
School of Basic Medicine, Ningxia Medical University, Yinchuan 750004, China;
4.
Yanjing Medical College, Capital Medical University, Beijing 101300, China

Corresponding author: LIU Hong-Yun, liuhongyun@bnu.edu.cn

Received Date: 12 October 2021
Revised Date: 20 November 2021
Fund Project:
Supported by the Key R&D Program of Ningxia Hui Autonomous Region of China (No.2018BEG03017), the Beijing Natural Science Foundation (No.2182027) and the Scientific Research Project of Tianjin Education Commission (No.2020KJ099)

Abstract: It is significant to develop efficient, rapid and simple methods for antibiotic detection because excess antibiotic residues have become one of the most serious threats to global public health. Molecularly imprinted polymers (MIPs), as artificial chemical receptors, can recognize and bind target molecules with high affinity and selectivity. Electrochemiluminescence (ECL) is a mature and widely used analytical technique. As a new analytical and detection technology, MIP-ECL technique is a very promising method for detection of antibiotic residues due to the advantages such as good selectivity, high sensitivity and low cost. In this review, the latest development of MIP-ECL antibiotic sensors, especially constructed with signal amplification strategies, is briefly introduced. Finally, current challenges and future perspectives for MIP-ECL sensors are discussed and prospected.

Key words:

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1.
沈阳化工大学材料科学与工程学院沈阳 110142

基于信号放大策略的分子印迹-电化学发光抗生素传感器研究进展

通讯作者: 刘红云,E-mail:liuhongyun@bnu.edu.cn

English

Progress of Molecularly Imprinted Polymers-Electrochemiluminescence Antibiotic Sensors Based on Signal Amplification Strategies

Corresponding author: LIU Hong-Yun, liuhongyun@bnu.edu.cn

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中国化学会秘书处

基于信号放大策略的分子印迹-电化学发光抗生素传感器研究进展

通讯作者: 刘红云,E-mail:liuhongyun@bnu.edu.cn

English

Progress of Molecularly Imprinted Polymers-Electrochemiluminescence Antibiotic Sensors Based on Signal Amplification Strategies

Corresponding author: LIU Hong-Yun, liuhongyun@bnu.edu.cn

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

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CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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中国化学会秘书处

CCS Chemistry：颜徐州、鲍哲南：你的皮肤可能是一片SPMs