点击化学和生物正交化学中的化学基础概念和前沿思想—

引用本文: 李恒宇, 赖铖阳, 黄思齐, 陈兴. 点击化学和生物正交化学中的化学基础概念和前沿思想——2022年诺贝尔化学奖浅析[J]. 大学化学, 2023, 38(1): 1-7. doi: 10.3866/PKU.DXHX202212058 shu

Citation: Hengyu Li, Chengyang Lai, Amelia Siqi Huang, Xing Chen. Basics and Frontiers of Click Chemistry and Bioorthogonal Chemistry: A Brief Introduction to 2022 Nobel Prize in Chemistry[J]. University Chemistry, 2023, 38(1): 1-7. doi: 10.3866/PKU.DXHX202212058 shu

点击化学和生物正交化学中的化学基础概念和前沿思想——2022年诺贝尔化学奖浅析

李恒宇 ^1, ,
赖铖阳 ^1, ,
黄思齐 ^2, ,
陈兴 ^{1,
,}

1.
北京大学化学与分子工程学院, 北京 100871;
2.
北京大学附属中学道尔顿学院, 北京 100190

通讯作者: 陈兴, xingchen@pku.edu.cn

基金项目:
国家重点研发计划(2018YFA0507600)；国家自然科学基金(92153301)

摘要: 2022年诺贝尔化学奖授予了Carolyn R. Bertozzi、Morten Meldal和K. Barry Sharpless三位科学家，以表彰他们开创了点击化学和生物正交化学。点击化学源于对有机合成方法学的改进，提供了一种在温和条件下高效快速地偶联化学分子的新方法。生物正交化学的开发则起始于生命体系中糖质生物大分子的特异性标记和成像，发展出一类不干扰生命体系且不受生命体系干扰的连接反应。二者殊途同归、异曲同工，成为了在化学、生物医药和材料科学等领域中应用最为广泛的一类化学反应。本文从点击化学与生物正交化学开发中所涉及的化学基础概念出发，对这两种方法的前沿思想进行简要探讨。

关键词:

English

Basics and Frontiers of Click Chemistry and Bioorthogonal Chemistry: A Brief Introduction to 2022 Nobel Prize in Chemistry

1.
College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China;
2.
Dalton Academy, The Affiliated High School of Peking University, Beijing 100190, China

Corresponding author: Xing Chen, xingchen@pku.edu.cn

Received Date: 20 December 2022

Abstract: The 2022 Nobel Prize in Chemistry was awarded to Carolyn R. Bertozzi, Morten Meldal, and K. Barry Sharpless, for the development of click chemistry and bioorthogonal chemistry. Stemming from the advances on the methodology of organic synthesis, click chemistry provides a versatile tool for coupling molecules with high efficiency under mild conditions. Orignially developed for specific labeling and visualization of glycans–an important biomacromolecule in living systems–bioorthogonal chemistry is a class of ligation reactions which neither interfere with nor being interfered by the surrounding biological milieu. Click chemistry and bioorthogonal chemistry are interconnected through similar philosophy and have emerged as the most useful chemical reactions in chemistry, biomedicine, and material science. Here, we briefly introduce the fundamental concepts and frontiers related to click chemistry and bioorthogonal chemistry.

Key words:

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沈阳化工大学材料科学与工程学院沈阳 110142

点击化学和生物正交化学中的化学基础概念和前沿思想——2022年诺贝尔化学奖浅析

通讯作者: 陈兴, xingchen@pku.edu.cn

English

Basics and Frontiers of Click Chemistry and Bioorthogonal Chemistry: A Brief Introduction to 2022 Nobel Prize in Chemistry

Corresponding author: Xing Chen, xingchen@pku.edu.cn

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中国化学会秘书处

点击化学和生物正交化学中的化学基础概念和前沿思想——2022年诺贝尔化学奖浅析

通讯作者: 陈兴, xingchen@pku.edu.cn

English

Basics and Frontiers of Click Chemistry and Bioorthogonal Chemistry: A Brief Introduction to 2022 Nobel Prize in Chemistry

Corresponding author: Xing Chen, xingchen@pku.edu.cn

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

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CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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