功能核酸生物传感器检测金属离子的研究进展

引用本文: 杜再慧, 李相阳, 田晶晶, 张洋子, 田洪涛, 许文涛. 功能核酸生物传感器检测金属离子的研究进展[J]. 分析化学, 2018, 46(7): 995-1004. doi: 10.11895/j.issn.0253-3820.171444 shu

Citation: DU Zai-Hui, LI Xiang-Yang, TIAN Jing-Jing, ZHANG Yang-Zi, TIAN Hong-Tao, XU Wen-Tao. Progress on Detection of Metals Ions by Functional Nucleic Acids Biosensor[J]. Chinese Journal of Analytical Chemistry, 2018, 46(7): 995-1004. doi: 10.11895/j.issn.0253-3820.171444 shu

功能核酸生物传感器检测金属离子的研究进展

1.
中国农业大学, 北京食品营养与人类健康高精尖创新中心, 北京 100083;
2.
中国农业大学, 食品科学与营养工程学院, 北京 100083;
3.
河北农业大学, 食品科技学院, 保定 071000;
4.
北京农学院, 食品科学与工程学院, 北京 102206
基金项目:
本文系北京市科技新星计划项目（No.xxjc201721）和国家自然科学基金项目（No.31671922）资助

摘要: 功能核酸是具有特定结构和功能的天然或人工核酸序列。一些金属离子是人体必需的微量元素，但过量的金属离子会对人体健康带来危害。功能核酸具有易于修饰、价格低廉、稳定性高、特异性强等优点，被广泛应用于金属离子的检测。本文详细介绍了功能核酸与金属之间的相互作用，主要包括DNA/RNA切割型、连接型、错配型、点击化学型、构象改变型以及其它类型；以及功能核酸与不同信号输出方式相结合的生物传感器。最后讨论了功能核酸在金属离子检测过程中的优势以及现存的问题，对功能核酸生物传感器未来的发展方向以及应用前景进行了展望。

关键词:

English

Progress on Detection of Metals Ions by Functional Nucleic Acids Biosensor

1.
Beijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing 100000, China;
2.
College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100000, China;
3.
College of Food Science and Technology, Agricultural University of Hebei, Baoding 071000, China;
4.
Food Science and Engineering College, Beijing University of Agriculture, Beijing 102206, China
Received Date: 22 November 2017
Revised Date: 24 March 2018
Fund Project:
This work was supported by the Beijing New-Star Plan of Science and Technology (No. xxjc201721) and the National Natural Science Foundation of China (No.31671922).

Abstract: Functional nucleic acids are natural or artificialnucleic acid sequences with specific functions and special structures. Special metal ions are essential trace elements for human health, but excessive metal ions will be harmful to human health. The functional nucleic acids are widely used in the detection of metal ions because of their advantages such as easy modification, low price, high stability and strong specificity. This review describes the function of functional nucleic acid and metal ions, mainly including cutting type, link type, metal ion-mediated base pairing, click chemical type, conformation change type, and other types. Then, biosensor of functional nucleic acid combined with different signal output is introduced. Finally, the research significance and problems of functional nucleic acid in metal ion detection are discussed, and the future development direction and application prospect of functional nucleic acid biosensor are prospected.

Key words:

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1.
沈阳化工大学材料科学与工程学院沈阳 110142

功能核酸生物传感器检测金属离子的研究进展

English

Progress on Detection of Metals Ions by Functional Nucleic Acids Biosensor

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

功能核酸生物传感器检测金属离子的研究进展

English

Progress on Detection of Metals Ions by Functional Nucleic Acids Biosensor

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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