引用本文:
Song Qing WANG, Omar A. ffiRAHIMI, Pan LI, Kang ZHAO. N-Alkoxyl Templates for Diastereoselective Pyrrolidine Synthesis[J]. Chinese Chemical Letters,
2004, 15(1): 1-4.
Citation: Song Qing WANG, Omar A. ffiRAHIMI, Pan LI, Kang ZHAO. N-Alkoxyl Templates for Diastereoselective Pyrrolidine Synthesis[J]. Chinese Chemical Letters, 2004, 15(1): 1-4.

Citation: Song Qing WANG, Omar A. ffiRAHIMI, Pan LI, Kang ZHAO. N-Alkoxyl Templates for Diastereoselective Pyrrolidine Synthesis[J]. Chinese Chemical Letters, 2004, 15(1): 1-4.

N-Alkoxyl Templates for Diastereoselective Pyrrolidine Synthesis
摘要:
Intramolecular cyclization of N-alkoxyl amines are studied for the stereoselective preparation of 2, 4-disubstituted pyrrolidine derivatives. Reduction of oximes under acidic conditions by NaBH3CN afforded the corresponding nucleophilic hydroxylamine derivatives, which subsequently cyclized via SN2'mechanism to give the desired N-alkoxyl pyrrolidines.
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关键词:
- SN'reaction
- / pyrrolidines
- / oxime
- / hydroxylamine
English
N-Alkoxyl Templates for Diastereoselective Pyrrolidine Synthesis
Abstract:
Intramolecular cyclization of N-alkoxyl amines are studied for the stereoselective preparation of 2, 4-disubstituted pyrrolidine derivatives. Reduction of oximes under acidic conditions by NaBH3CN afforded the corresponding nucleophilic hydroxylamine derivatives, which subsequently cyclized via SN2'mechanism to give the desired N-alkoxyl pyrrolidines.
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Key words:
- SN'reaction
- / pyrrolidines
- / oxime
- / hydroxylamine

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