N-Alkoxyl Templates for Diastereoselective Pyrrolidine Synthesis

Song Qing WANG Omar A. ffiRAHIMI Pan LI Kang ZHAO

引用本文: Song Qing WANG,  Omar A. ffiRAHIMI,  Pan LI,  Kang ZHAO. N-Alkoxyl Templates for Diastereoselective Pyrrolidine Synthesis[J]. Chinese Chemical Letters, 2004, 15(1): 1-4. shu
Citation:  Song Qing WANG,  Omar A. ffiRAHIMI,  Pan LI,  Kang ZHAO. N-Alkoxyl Templates for Diastereoselective Pyrrolidine Synthesis[J]. Chinese Chemical Letters, 2004, 15(1): 1-4. shu

N-Alkoxyl Templates for Diastereoselective Pyrrolidine Synthesis

  • 基金项目:

    KZ acknowledges support from the National Young Scholar Award of the NSFC (#30125043), from the Basic Research Project (#2002CCA01500) of MOST, and from the Chung Kong Scholars Program administered by the Ministry of Education (PRC) and the Li Ka Shing Foundation (Hong Kong).

摘要: Intramolecular cyclization of N-alkoxyl amines are studied for the stereoselective preparation of 2, 4-disubstituted pyrrolidine derivatives. Reduction of oximes under acidic conditions by NaBH3CN afforded the corresponding nucleophilic hydroxylamine derivatives, which subsequently cyclized via SN2'mechanism to give the desired N-alkoxyl pyrrolidines.

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  • 收稿日期:  2002-11-15
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